In vitro antibacterial and cytotoxicity assessment of magnetron sputtered Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloy doped with Ag nanoparticles

Alamdari, Armin Asghari; Hashemkhani, Mahshid; Hendessi, Saman; Güner, Pınar Tatar; Acar, Havva Yağcı; Kavaklı, İbrahim Halil; Ünal, Uğur; Motallebzadeh, Amir

doi:10.1016/j.vacuum.2022.111286

Cited by 10 publications

(7 citation statements)

References 29 publications

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“…Ag nanoparticles are doped in the surface of Ti 1.5 ZrTa 0.5 Nb 0.5 W 0.5 HEAs using radio frequency (RF) magnetron sputtering. [39,40] The elemental segregation is not found in transmission electron microscopy (TEM)-EDS elemental mapping. The antibacterial properties are tested by colony forming units using incubation with P. aeruginosa (gram-negative) and S. aureus (gram-positive).…”

Section: Antibacterial Propertiesmentioning

confidence: 99%

Corrosion‐Resistant Biomedical High‐Entropy Alloys: A Review

Shi,

Fang,

Liaw

et al. 2023

Adv Eng Mater

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High entropy alloys (HEAs) exhibit the outstanding properties, such as excellent antibacterial property, remarkable biocompatibility, and superior corrosion resistance, in the field of biomedical applications. Herein, we summarize the biomedical function of HEAs in aspects of the antibacterial behavior against planktonic gram‐negative/gram‐positive bacteria and biofilms, the biocompatibility inspired by low‐ cytotoxicity alloying elements. Considering the corrosive service environment of biomedical device, the corrosion behavior and mechanism are discussed in terms of alloying elements (Al, Ni, Cr, and Cu) and microstructure (phase composition and grain size). Additionally, the promising approaches to simultaneously achieve biomedical function and corrosion resistance, the possible application of additive manufacturing, and the prospective effects of short‐range orderings on the corrosion resistance are simply discussed.This article is protected by copyright. All rights reserved.

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Section: Antibacterial Propertiesmentioning

confidence: 99%

Corrosion‐Resistant Biomedical High‐Entropy Alloys: A Review

Shi,

Fang,

Liaw

et al. 2023

Adv Eng Mater

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“…High entropy alloys (HEAs), especially their nanoparticles (HEA‐NPs), have been recognized as promising candidates due to their multi‐composed elements and photothermal conversion performance. [ 15 ] Recently, HEAs composed of Cu elements such as Al 0.4 CoCrCuFeNi, [ 16 ] Ti‐13Nb‐13Zr‐10Cu, [ 17 ] AlCoCrCu 0.5 FeNi, [ 18 ] and Co 0.4 FeCr 0.9 Cu x [ 19 ] have been proven effective in antibacterial performance due to their Cu elements. Meanwhile, it has been noticed that HEA‐NPs synthesized by 3 d transition elements could promote the optical absorption property and thus realize photothermal heating performance.…”

Section: Introductionmentioning

confidence: 99%

Photothermal Heating‐Assisted Superior Antibacterial and Antibiofilm Activity of High‐Entropy‐Alloy Nanoparticles

Yang

Liao

et al. 2023

Adv Funct Materials

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Antibacterial elements and non‐contact heating abilities have been proven effective for antibacterial and antibiofilm activities, but it remains a challenge to integrate both within one material. Herein, assisted by the high‐entropy effect, FeNiTiCrMnCux high‐entropy alloy nanoparticles (HEA‐NPs) with excellent photothermal heating properties for boosting antibacterial and antibiofilm performances are synthesized. Benefitting from the synergetic effect of copper ions released and thermal damage by the HEA‐NPs, more reactive oxygen species (ROS) are generated, leading to the rupture of the cell membranes and the eradication of the biofilms. As a result, the antibiofilm efficiency (400 µg mL−1) of the mostly optimized FeNiTiCrMnCu1.0 HEA‐NPs in the marine nutrient medium, which is the worst‐case scenario for the antimicrobial material, can be improved from 81% to 97.4% under 30 min solar irradiation (1 sun). The present study demonstrates a new strategy for effectively treating marine microorganisms that cause biofouling and microbial corrosion using HEA‐NPs with photothermal heating characteristics as an antibacterial auxiliary.

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“…12,13 Polyelemental alloys possess excellent mechanical and chemical stability attributing to their configurational mixing entropy. 14 Alamdari et al 9 reported the substantial 98.5% antibacterial efficacy of the TiZrTaNbWAg polyelemental film against Escherichia coli (E. coli) bacteria. Murray et al 10 reported the 6.4 log reduction of the double-stranded deoxyribonucleic acid (DNA) activity of E. coli bacteria after interacting with the CoCuAgNiSi polyelemental film.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Polyelemental materials − are an emerging class of materials with vast compositional space that can be tuned to promote the synergistic properties of alloyed materials for various applications ranging from clean energy , to healthcare , and structural materials. , Recent studies show the potential of polyelemental materials for biological applications such as antibacterial agents − or medical implants. , Polyelemental alloys possess excellent mechanical and chemical stability attributing to their configurational mixing entropy . Alamdari et al reported the substantial 98.5% antibacterial efficacy of the TiZrTaNbWAg polyelemental film against Escherichia coli (E. coli) bacteria.…”

Section: Introductionmentioning

confidence: 99%

Enhanced Bacterial Growth by Polyelemental Glycerolate Particles

Phakatkar

Gonçalves

Zhou

et al. 2023

ACS Appl. Bio Mater.

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While polyelemental alloys are shown to be promising for healthcare applications, their effectiveness in promoting bacterial growth remains unexplored. In the present work, we evaluated the interaction of polyelemental glycerolate particles (PGPs) with Escherichia coli (E. coli) bacteria. PGPs were synthesized using the solvothermal route, and nanoscale random distribution of metal cations in the glycerol matrix of PGPs was confirmed. We observed 7-fold growth of E. coli bacteria upon 4 h of interaction with quinary glycerolate (NiZnMnMgSr-Gly) particles in comparison to control E. coli bacteria. Nanoscale microscopic studies on bacteria interactions with PGPs showed the release of metal cations in the bacterium cytoplasm from PGPs. The electron microscopy imaging and chemical mapping indicated bacterial biofilm formation on PGPs without causing significant cell membrane damage. The data showed that the presence of glycerol in PGPs is effective in controlling the release of metal cations, thus preventing bacterial toxicity. The presence of multiple metal cations is expected to provide synergistic effects of nutrients needed for bacterial growth. The present work provides key microscopic insights of mechanisms by which PGPs enhance biofilm growth. This study opens the door for future applications of PGPs in areas where bacterial growth is essential including healthcare, clean energy, and the food industry.

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In vitro antibacterial and cytotoxicity assessment of magnetron sputtered Ti1.5ZrTa0.5Nb0.5W0.5 refractory high-entropy alloy doped with Ag nanoparticles

Cited by 10 publications

References 29 publications

Corrosion‐Resistant Biomedical High‐Entropy Alloys: A Review

Corrosion‐Resistant Biomedical High‐Entropy Alloys: A Review

Photothermal Heating‐Assisted Superior Antibacterial and Antibiofilm Activity of High‐Entropy‐Alloy Nanoparticles

Enhanced Bacterial Growth by Polyelemental Glycerolate Particles

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