In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria, Streptococcus mutans and Streptococcus sobrinus

Choi, Okhee; Cho, Su Kyung; Kim, Junheon; Park, Chung Gyoo; Kim, Jin-Woo

doi:10.1016/j.apjtb.2016.01.007

Cited by 59 publications

(44 citation statements)

References 29 publications

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“…Because we used EO distilled from the leaves, we suggest that the difference is probably caused by the compositions of the eucalyptus oils in the experiments [20]. Parallel to our results, a previous publication has reported the same inhibitory trend and cited strong antibacterial character of cinnamon bark and cinnamaldehyde against S. mutans [21]. Against this pathogen, antibiofilm activity of eucalyptus oil was also published [22].…”

Section: Discussionsupporting

confidence: 82%

Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens

Ács

Balázs

Kocsis

et al. 2018

BMC Complement Altern Med

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BackgroundThe increasing number of multidrug-resistant bacteria and the fact of antibiotic resistance is leading to a continuous need for discovering alternative treatments against infections, e.g. in the case of respiratory tract diseases. Essential oils (EOs), because of their volatility, can easily reach both the upper and lower parts of the respiratory tract via inhalation. Therefore, the aim of the present study was the antibacterial evaluation of clove, cinnamon bark, eucalyptus, thyme, scots pine, peppermint, and citronella EOs against respiratory tract pathogens such as Streptococcus pneumoniae, S. mutans, S. pyogenes, Haemophilus influenzae, H. parainfluenzae, and Moraxella catarrhalis. Furthermore, we wanted to compare the antibacterial effect of these EOs in two different test systems to provide data for the development of an appropriate product formulation.MethodsMinimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were determined with in vitro vapor phase test (VPT) and broth macrodilution test (BDT). The chemical and percentage compositions of the EOs were determined by GC-MS and GC-FID analysis.ResultsAmong the EOs, thyme was the most effective against S. mutans (MIC: 0.04 mg/mL in BDT, but cinnamon bark and clove oils also presented high inhibition in liquid medium with MIC values of 0.06 mg/mL and 0.1 mg/mL against S. pneumoniae and S. pyogenes, respectively. M. catarrhalis was the most sensitive to thyme EO (MIC: 0.09 mg/mL). Cinnamon bark EO was the most effective against Haemophilus spp. (MIC: 0.06 mg/mL). In the VPT, cinnamon bark was the most effective oil against all investigated pathogens with MIC values in the range of 15.62–90 μl/L. Surprisingly, the eucalyptus and scots pine showed weak activity against the test bacteria in both test systems.ConclusionsThe EO of thyme, clove and cinnamon bark may provide promising antibacterial activity against respiratory tract pathogens either in liquid medium or in vapor phase. However, their effect is lower than that of the reference antibiotics. The combination of EOs and antibiotics may be beneficial in the alternative treatment of respiratory tract diseases. In vivo studies are necessary to calculate the effective dose of EOs in patients and determine their possible side effects and toxicity.

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Section: Discussionsupporting

confidence: 82%

Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens

Ács

Balázs

Kocsis

et al. 2018

BMC Complement Altern Med

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“…Similarly to our results, they also demonstrated slight cytotoxic effect of cinnamon EO against Vero cell line (green monkey kidney epithelial cells)—IC 50 = 49.4 ± 1.12 μg/mL after 24 h exposure [ 2 ]. Whereas, Choi et al showed relevant antibacterial activity of C. verum EO against Streptococcus mutans and Streptococcus sobrinus [ 10 ].…”

Section: Resultsmentioning

confidence: 99%

Antimycobacterial Activity of Cinnamaldehyde in a Mycobacterium tuberculosis(H37Ra) Model

et al. 2018

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The purpose of the study was to evaluate the antimycobacterial activity and the possible action mode of cinnamon bark essential oil and its main constituent—cinnamaldehyde—against the Mycobacterium tuberculosis ATCC 25177 strain. Cinnamaldehyde was proved to be the main bioactive compound responsible for mycobacterial growth inhibition and bactericidal effects. The antimycobacterial activity of cinnamaldehyde was found to be comparable with that of ethambutol, one of the first-line anti-TB antibiotics. The selectivity index determined using cell culture studies in vitro showed a high biological potential of cinnamaldehyde. In M. tuberculosis cells exposed to cinnamaldehyde the cell membrane stress sensing and envelope preserving system are activated. Overexpression of clgR gene indicates a threat to the stability of the cell membrane and suggests a possible mechanism of action. No synergism was detected with the basic set of antibiotics used in tuberculosis treatment: ethambutol, isoniazid, streptomycin, rifampicin, and ciprofloxacin.

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“…The reported MIC of cinnamaldehyde against S. mutans and S. sorbinus was 0.02% ( v/v ), and the MBC was 0.2% and 0.1% ( v/v ), respectively, which is in the range of the MIC against C. albicans (0.01–0.05%) but is higher than the mean MIC of the cinnamon EO and extracts ( Table 4 ). This suggests that cinnamaldehyde could be used as an alternative to cinnamon EO [ 32 , 70 , 106 ]. The antimicrobial effects of cinnamaldehyde and eugenol against P. gingivalis produced MICs of 2.5 and 31.25 μM, respectively [ 101 , 108 ].…”

Section: Discussionmentioning

confidence: 99%

“…Cinnamon EO showed the highest antibacterial activity against S. mutans among eight other EOs tested, including lime, spearmint, wintergreen, peppermint, lemongrass, cedarwood, clove, and eucalyptus EOs [ 69 ]. In a vast study investigating the antimicrobial properties of 32 EOs against oral pathogens, S. mutans , Streptococcus sobrinus, and C. zeylanicum EOs proved to be the most effective based on the inhibition zone measurements [ 70 ]. The antimicrobial effects of cinnamon against S. mutans and Lactobacillus plantarum proved to be stronger in comparison to tea tree, manuka, arnica, eucalyptus, and grapefruit [ 71 ].…”

Section: Antimicrobial Effect Of Cinnamon Eo and Cinnamon Extractsmentioning

confidence: 99%

“…Both tested strains showed moderate sensitivity to 3-carene, α-Terpinene, benzaldehyde, linalool, β-Caryophyllene, α-Humulene, α-Terpineol, hydrocinnamic aldehyde, hydrocinnamyl acetate, and cinnamyl acetate. The MIC of cinnamaldehyde against both bacterial strains was 0.02% ( v/v ), whereas the MBCs against S. mutans and S. sorbinus were 0.2% and 0.1% ( v/v ), respectively [ 70 ]. C. zeylanicum , due to its main constituent t -Cinnamaldehyde, showed the highest antibacterial activity against several bacteria, with clinical significance among all the tested EOs (cumin ( Cuminum cyminum ), C. verum , cardamom ( Amomum subulatum ), and clove ( S. aromaticum )) [ 102 ].…”

Section: Main Constituents Of Cinnamomum Spp Amentioning

confidence: 99%

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Effects of Cinnamon (Cinnamomum spp.) in Dentistry: A Review

Yanakiev

2020

Molecules

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Dental medicine is one of the fields of medicine where the most common pathologies are of bacterial and fungal origins. This review is mainly focused on the antimicrobial effects of cinnamon essential oil (EO), cinnamon extracts, and pure compounds against different oral pathogens and the oral biofilm and the possible effects on soft mouth tissue. Basic information is provided about cinnamon, as is a review of its antimicrobial properties against the most common microorganisms causing dental caries, endodontic and periodontal lesions, and candidiasis. Cinnamon EO, cinnamon extracts, and pure compounds show significant antimicrobial activities against oral pathogens and could be beneficial in caries and periodontal disease prevention, endodontics, and candidiasis treatment.

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In vitro antibacterial activity and major bioactive components of Cinnamomum verum essential oils against cariogenic bacteria, Streptococcus mutans and Streptococcus sobrinus

Cited by 59 publications

References 29 publications

Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens

Antibacterial activity evaluation of selected essential oils in liquid and vapor phase on respiratory tract pathogens

Antimycobacterial Activity of Cinnamaldehyde in a Mycobacterium tuberculosis(H37Ra) Model

Effects of Cinnamon (Cinnamomum spp.) in Dentistry: A Review

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