In vitro antibacterial activities of selected TB drugs in the presence of clay minerals against multidrug-resistant strain of Myco<i>bacterium smegmatis</i>

Arthur, Patrick Kobina; Amarh, Vincent; Blessie, Ethel J. S.; Yeboah, Rebecca; Kankpeyeng, Benjamin W.; Nkumbaan, Samuel N.; Tiburu, Elvis K.

doi:10.1080/23311916.2020.1742853

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…According to García-Villén et al [ 29 ], clay minerals allow multiple pathways for interactions with microorganisms, decreasing water activity and cell adhesion, proliferation, and the formation of neotissues. All these characteristics make these nanoparticles viable to be explored in obtaining effective anti-TB drug delivery systems, making them promising candidates for improving therapeutic efficacy in disease treatment, including the treatment of multidrug-resistant infections [ 30 ].…”

Section: Introductionmentioning

confidence: 99%

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Montmorillonite–Rifampicin Nanohybrid for pH-Responsive Release of the Tuberculostatic

et al. 2023

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The present work describes the development of a hybrid and pH-responsive system for rifampicin using the clay mineral ‘montmorillonite’ as a nanocarrier. The influence of operational variables on the drug incorporation process was evaluated using 24 factorial designs. Under optimized conditions, the experiment allowed an incorporated drug dose equivalent to 98.60 ± 1.21 mg/g. Hybrid systems were characterized by different characterization techniques (FTIR, XRD, TGA, DSC, and SEM) to elucidate the mechanism of interaction between the compounds used. Through in vitro release studies, it was possible to verify the efficacy of the pH-dependent system obtained, with approximately 70% of the drug released after sixteen hours in simulated intestinal fluid. The adjustment of the experimental release data to the theoretical model of Higuchi and Korsmeyer–Peppas indicated that the release of rifampicin occurs in a prolonged form from montmorillonite. Elucidation of the interactions between the drug and this raw clay reinforces its viability as a novel carrier to develop an anti-TB/clay hybrid system with good physical and chemical stability.

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Section: Introductionmentioning

confidence: 99%

“…We have previously described how to obtain this type of system for the drugs isoniazid and rifampicin using the clay mineral palygorskite [ 4 , 20 ]. Other systems for anti-TB drugs, based on montmorillonite [ 34 ], halloysite [ 30 , 35 , 36 ], and palygorskite [ 1 , 37 ], have also been reported.…”

Section: Introductionmentioning

confidence: 99%