In vitro anti-urolithic activity of Chandraprabavathi – A herbo-mineral formulation

Abstract

Chandraprbhavati (CPV) is an Ayurvedic formulation clinically used in the management of urinary calculi. The present study was undertaken to investigate the in-vitro antiurolithic activity of CPV by artificial urine and nucleation assay. Cystone demonstrated better percentage inhibition of calcium oxalate crystals formation than CPV in nucleation assay, however CPV exhibited more inhibition of super saturation of calcium oxalate crystals in artificial urine assay than cystone. The percentage inhibition of calcium oxalate crystals formation increased in dose dependent manner for both the drugs. Thus our study demonstrates primary evidence for CPV possessing antiurolithiatic property in vitro.