In vitro anti trypanosomal activity of some medicinal plants used in the treatment of trypanosomosis in Northern Nigeria

Wurochekke, A. U.; Nok, AJ

doi:10.5897/ajb2004.000-2094

Cited by 26 publications

(16 citation statements)

References 7 publications

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“…It is thus possible for any plants that did not show activity to a species of the parasite, thus can have activity against other species of the parasites. 1,40 Moreover, the result suggestive and similar with that reports that some plants had promising activity against trypanosomes. 2,15,20,48,49 The morphology of the blood cells was maintained while that of the parasites was affected when compared to the control that still had very active parasites.…”

Section: Discussionsupporting

confidence: 79%

“…Trypanosomosis is one of the major obstacles for livestock production in Africa, 1 and continues to cause morbidity and mortality on a large scale in the world. 2 The trypanosomes had been first reported to occur in trouts (Valentine, 1841) and frogs (Gluge, 1842), 3 but it was not until 1881 that Griffith Evans found trypanosomes in the blood of horses and camels with a wasting disease called Surra and suggested that the parasites might be the cause of this disease.…”

Section: Introductionmentioning

confidence: 99%

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In vitro antitrypanosomal potential of chloroform leaf extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi

Fathuddin

Inabo

2017

Microbiol Res (Pavia)

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The plant Pomegranate (Punica granatum Linn.) selected for this study is native to the region of Eurasia. The objective of this study was to evaluate the antitrypanosomal potential of the plant against Trypanosoma brucei brucei (T.b. brucei) and Trypanosoma evansi (T. evansi). Similarly, the parasites used for this study have two entirely different modes of transmission that is Cyclical Transmission (T.b. brucei) and Mechanical Transmission (T. evansi). The chloroform extract of Punica granatum (P. granatum) was analysed in vitro for trypanocidal activity against T.b. brucei and T. evansi at concentrations of 100 mg/mL, 50 mg/mL, 25 mg/mL, 12.5 mg/mL and 6.25 mg/mL. The chloroform extracts of P. granatum had trypanocidal activity against T. evansi and was inactive against T.b. brucei. These findings suggest that the mode of transmission may have an effect on the parasite-drug reaction and the possible use of the chloroform extract of P. granatum in the management of trypanosomiasis due to T. evansi which may require further elucidation.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

In vitro antitrypanosomal potential of chloroform leaf extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi

Fathuddin

Inabo

2017

Microbiol Res (Pavia)

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“…Seventeen plants have been studied previously against parasitic diseases as summarized in Table 1. The most common reports are against Plasmodium (Antoun et al, 2001;Andrade-Neto et al, 2004;Rodríguez et al, 2006;Kvist et al, 2006) and Trypanosoma (Gonzalez-Coloma et al, 2002;Talakal et al, 1995;Wurochekke & Nok, 2004) parasites. We did not find antiparasitic reports for three plants.…”

Section: Discussionmentioning

confidence: 99%

Screening of medicinal plants againstLeishmania amazonensis

García¹,

Monzote²,

Montalvo³

et al. 2010

Pharmaceutical Biology

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“…In Africa, herbal treatment has a long tradition and still holds a strong position in medical care. In Nigeria, traditional healers use medicinal plants either alone or in combination to treat both human and animal trypanosomosis (Wurochekke and Nok, 2004). Several reports exist on the herbal treatment of sleeping sickness (Asuzu and Chineme, 1990; Asuzu and Anaga, 1991; Wurochekke and Nok, 2004).…”

Section: Introductionmentioning

confidence: 99%

Investigation of the Antitrypanosomal Activity of <i>Buchholzia coriacea</i> Seed Extract against a Field Strain of <i>Trypanosoma congolense</i>

Nweze

Anene

Asuzu

2011

Afr. J. Trad. Compl. Alt. Med.

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The antitrypanosomal activity of the methanol extract of Buchholzia coriacea seed against a field strain of Trypanosoma congolense was investigated using experimentally infected mice of both sexes. Monitoring of parasitaemia was by the rapid matching technique. When parasitaemia was approximately log 7.8 (63 x 10 6 parasites/ml), treatment with graded doses of the extract (250, 500 and 1000 mg/kg) was instituted for 5 consecutive days. Diminazene diaceturate (Dimivet ® SKM Pharma Pvt. Ltd.) was given at 3.5 mg/kg i.p. to the positive control mice. No significant differences in body weights were observed. The rectal temperatures of infected mice showed fluctuations. The PCV of infected mice were significantly (p < 0.05) lower than those of the uninfected controls. There was no significant difference between the PCV of the extract-treated and untreated animals. Parasitaemia increased steadily in the extract-treated and untreated mice groups till all the animals died. Three days post-treatment with diminazene diaceturate parasitaemia was cleared. Six days later, there was a relapse of infection. By the end of the experiment, a 50 % relapse rate was recorded in the diminazene diaceturatetreated group. The methanol extract of Buchholzia coriacea seeds did not show any antitrypanosomal activity in mice infected with Trypanosoma congolense at the doses tested.

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In vitro anti trypanosomal activity of some medicinal plants used in the treatment of trypanosomosis in Northern Nigeria

Cited by 26 publications

References 7 publications

In vitro antitrypanosomal potential of chloroform leaf extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi

In vitro antitrypanosomal potential of chloroform leaf extract of Punica granatum L. on Trypanosoma brucei brucei and Trypanosoma evansi

Screening of medicinal plants againstLeishmania amazonensis

Investigation of the Antitrypanosomal Activity of <i>Buchholzia coriacea</i> Seed Extract against a Field Strain of <i>Trypanosoma congolense</i>

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