In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea

Gonçalves, Jorge Luiz S.; Lopes, Rosana Conrado; Oliveira, De; Costa, Sônia Soares; Miranda, Mauro Sayão de; Romanos, Maria Teresa V.; Santos, Norma; Wigg, M.D.

doi:10.1016/j.jep.2005.01.032

Cited by 133 publications

(70 citation statements)

References 14 publications

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“…Animal models as well as controlled human studies showed that its fruit, leaf and root are safe and without side effect (Kamath et al, 2008;Nwinyi et al, 2008). The leaf decoction is taken for its hepatoprotective qualities (Kamath et al, 2008), also as a remedy for throat and chest ailments (Gutierrez et al, 2008), cough, pulmonary diseases, anti-inflammatory and homeostatic agent (Goncalves et al, 2005). It is also taken as an emmenagogue and vermifuge and treatment of leucorrhea (Goncalves et al, 2005;Gutierrez et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

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Protective Role of Aqueous Guava Leaf Extract Against Caffeine Induced Spermatotoxicity in Albino Rats

Ekaluo¹,

Ikpeme²,

Uno³

et al. 2016

Research J. of Medicinal Plant

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This study investigated the protecting potential of Aqueous Guava (Psidium guajava) Leaf Extract (AGLE) against caffeine induced spermatotoxicity in albino rat models. Thirty healthy and sexually matured albino rats were divided into five groups of six rats each using a completely randomized design. They were treated with caffeine and AGLE combinations orally for 65 days. The result showed that caffeine significantly (p<0.05) reduced sperm viability, sperm count and sperm motility, while sperm head abnormality increased in caffeine treated rats when compared to the control. However, AGLE significantly (p<0.05) protected the treated albino rat models from caffeine induced spermatotoxicity in a dose-dependent manner. These results show that AGLE is effective in protecting albino rat models against caffeine induced spermatotoxicity in a dose dependent manner.

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Section: Introductionmentioning

confidence: 99%

“…The leaves are also chewed or gargled to relieve oral ulcer, toothache and inflamed gums (Pamplona-Roger, 1999;Goncalves et al, 2005). Res.…”

Section: Introductionmentioning

confidence: 99%

Protective Role of Aqueous Guava Leaf Extract Against Caffeine Induced Spermatotoxicity in Albino Rats

Ekaluo¹,

Ikpeme²,

Uno³

et al. 2016

Research J. of Medicinal Plant

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“…Specifically, in the European region rotavirus infection causes an estimated 6,550 deaths and 146,287 hospital admissions each year in children under 5 years of age. The average percentages of diarrheal disease admissions attributable to rotavirus have been estimated at 26.4% (low-income countries), 21.3% (lower-middle-income countries), 31.7% (upper-middle-income countries), and 39.5% (high-income countries) (51).…”

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confidence: 99%

“…These studies included different probiotic strains, like Bifidobacterium bifidum and Streptococcus thermophilus (43), Lactobacillus paracasei (45), Lactobacillus rhamnosus GG (23,36), and the probiotic mixture VSL3 (11). Although direct effects have been reported for the addition of different products, such as isoflavones from soy (1), lactose-based sialyl mimetics (31), and medicinal plants (21), on the inhibition of rotavirus replication, to our knowledge there are very few in vivo data that clearly demonstrate the capacity of a probiotic or a probiotic metabolite to inhibit rotavirus infection. In fact, for all the previously reported cases, the protection mechanisms remain unclear.…”

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confidence: 99%

Novel Probiotic Bifidobacterium longum subsp. infantis CECT 7210 Strain Active against Rotavirus Infections

Muñoz

Chenoll

Casinos

et al. 2011

Appl Environ Microbiol

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Rotavirus is the leading cause of severe acute gastroenteritis among children worldwide. It is well known that breast-feeding and vaccination afford infants protection. Since breast-feeding has drastically decreased in developed countries, efforts have been focused on the potential use of probiotics as preventive agents. In this study, a novel Bifidobacterium longum subsp. infantis strain was isolated from infant feces and selected, based on its capacity to inhibit in vitro rotavirus Wa replication (up to 36.05% infectious foci reduction) and also to protect cells from virus infection (up to 48.50% infectious foci reduction) in both MA-104 and HT-29 cell lines. Furthermore, studies using a BALB/c mouse model have proved that this strain provides preliminary in vivo protection against rotavirus infection. The strain has been deposited in the Spanish Type Culture Collection under the accession number CECT 7210. This novel strain has the main properties required of a probiotic, such as resistance to gastrointestinal juices, biliary salts, NaCl, and low pH, as well as adhesion to intestinal mucus and sensitivity to antibiotics. The food safety status has been confirmed by the absence of undesirable metabolite production and in acute ingestion studies of mice.Overall, these results demonstrate that Bifidobacterium longum subsp. infantis CECT 7210 can be considered a probiotic able to inhibit rotavirus infection.

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“…Also, the biological diversity of nature is the source of a wide range of bioactive molecules (De Clercq, 2005). It is known that secondary metabolites have a wide spectrum of biological activities, including potential antiviral effect (Goncalves et al, 2005;Palombo, 2006).…”

Section: Introductionmentioning

confidence: 99%

In Vitro Studies of Some Medicinal Plants Extracts for Antiviral Activity against Rotavirus

AL-Ballawi¹,

Redhwan²,

Ali³

2017

IOSRJPBS

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In vitro anti-rotavirus activity of some medicinal plants used in Brazil against diarrhea

Cited by 133 publications

References 14 publications

Protective Role of Aqueous Guava Leaf Extract Against Caffeine Induced Spermatotoxicity in Albino Rats

Protective Role of Aqueous Guava Leaf Extract Against Caffeine Induced Spermatotoxicity in Albino Rats

Novel Probiotic Bifidobacterium longum subsp. infantis CECT 7210 Strain Active against Rotavirus Infections

In Vitro Studies of Some Medicinal Plants Extracts for Antiviral Activity against Rotavirus

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