In vitro anti-plasmodial activity of some traditionally used medicinal plants against Plasmodium falciparum

Abstract

The anti-plasmodial activity of different solvent extracts of Adhatoda vasica (root), Caesalpinia pulcherrima (leaf), Carica papaya (pulp), Erythroxylum monogynum (leaf), Lantana camara (whole plant), Ocimum sanctum (root) and Phyllanthus niruri (whole plant) were studied against Plasmodium falciparum. Of the 35 extracts tested, seven extracts showed good anti-plasmodial activity. Methanol extract of C. pulcherrima showed the lowest IC50 value (10.96 μg/mL) followed by methanol extract of A. vasica (IC(50)=11.1 μg/mL), chloroform extract of O. sanctum (IC(50)=11.47 μg/mL), methanol extract of E. monogynum (IC(50)=12.23 μg/mL), acetone extract of C. pulcherrima (IC(50)=12.49 μg/mL), methanol extract of O. sanctum and acetone extract of A. vasica (IC(50)=14.04 μg/mL). The results of the present study justify the use of these medicinal plants in traditional practice, and also, a further study on the isolation of anti-plasmodial molecules from their active crude extracts is in progress.

Ethnomedicinal Plants Used for the Treatment of Malaria in Malaka, West Timor

“…antiplasmodial activity against P. falciparum in vitro. 14,15 Three species in this research with the highest RFC values for oral use, namely C. gigantea, C. rutidosperma and P. angulata are also known as traditional antimalarial medicine in Africa, Asia, and America. In the evaluation of their antimalarial activity, the extracts of C. gigantea and P. angulata showed a strong activity (IC 50 value <10 μg/mL) against P. falciparum.…”

“…12 C. papaya leaf extract showed good in vivo and in vitro antimalarial activities. 13,14 Ocimum sp., P. niruri, Aegle marmelos and M. charantia were also used in India as antimalarials; and showed good recipes for remedy could be a single or a combination of various species of plants or plant parts. To prepare a plant material into medicine, it was processed simply, for example crushing and mixing with a little amount of water or oil for massage; soaking the whole or ground for a mixture of bath water; or boiling with water for a drink.…”

In VivoAntiprotozoal Activity of the Chloroform Extract fromCarica papayaSeeds against Amastigote Stage ofTrypanosoma cruziduring Indeterminate and Chronic Phase of Infection

“…The use of C. papaya has been recurrent in the traditional medicine having a significant number of reports due to their properties for the treatment such as skin ulcers [17] and antiprotozoal activity against Leishmania amazonensis [18], Trichomonas vaginalis [6], and Plasmodium falciparum ( P. falciparum ) [19]. The antiprotozoal activity of the chloroform crude extract of C. papaya during the subacute and chronic phase of Chagas' disease is demonstrated in this study in concordance with previous reports [7].…”

Pharmacological and phytochemical evaluation of Ocimum sanctum root extracts for its antiinflammatory, analgesic and antipyretic activities

“…Hence, suitable methods should be adopted to minimize the pollution of environment by converting waste materials to value added products. OS roots extracts possess anti-plasmodial,[ 16 ] anti-depressant[ 17 ] activities. The present study was carried out to determine the anti-inflammatory, analgesic and antipyretic profile of OS root extracts using small laboratory animals.…”