In vitro anti-inflammatory and anti-oxidant activities of Sri Lankan medicinal plants

Perera, Hettiarachchige Dona Sachindra Melshandi; Samarasekera, Jayanetti Koralalage Ramani Radhika; Handunnetti, SM; Weerasena, Ovitigala Vithanage Don Sisira Jagathpriya

doi:10.1016/j.indcrop.2016.09.009

Cited by 42 publications

(37 citation statements)

References 47 publications

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“…In the present study, an increase in ROS formation observed in the serum of infected animals may be considered a host defence against I. multifiliis, but the excessive ROS directly damages the surrounding tissue or cells, promoting oxidative and inflammatory processes (Ritter et al, 2017). According to Perera et al (2016), the augmentation of XO activity is linked with an important source of ROS production, which may contribute to oxidative stress in the liver, gills and muscle of silver catfish experimentally infected with I. multifiliis observed by Garcia et al (2011).…”

Section: Seric Xo Activity and Uric Acid Levelsmentioning

confidence: 79%

“…According to Perera et al. (), the augmentation of XO activity is linked with an important source of ROS production, which may contribute to oxidative stress in the liver, gills and muscle of silver catfish experimentally infected with I. multifiliis observed by Garcia et al. ().…”

Section: Discussionmentioning

confidence: 99%

“…Xanthine oxidase is a flavoprotein, which catalyses the hydroxylation of hypoxanthine to xanthine and xanthine to uric acid (Sahgal et al., ). Recent data have indicated that XO has a pathogenetic role in various forms of infectious diseases due to the formation of reactive oxygen species (ROS) during catalytic function of the enzyme (Perera, Samarasekera, Handunneti, & Weerasena, ), including during parasitic infections (Doleski et al., ). In this sense, increased XO activity is reported to be associated with oxidative stress in many infectious diseases, such as that caused by protozoan Toxoplasma gondii (Doleski et al., ).…”

Section: Introductionmentioning

confidence: 99%

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Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

Baldissera

Souza

Doleski

et al. 2017

Journal of Fish Diseases

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Adenosine deaminase (ADA) activity, through adenosine (Ado) levels, as well as xanthine oxidase (XO) activity through uric acid levels exerts an essential role on immune and inflammatory responses during infectious diseases. Thus, the aim of this study was to evaluate the involvement of seric ADA and XO activities in the inflammatory and oxidative status of silver catfish naturally infected with Ichthyophthirius multifiliis. Seric ADA activity decreased, while Ado levels increased in infected animals compared to uninfected animals. Moreover, the seric XO activity increased in infected animals compared to uninfected animals, alongside the seric levels of uric acid, metabolites of nitric oxide (NOx) and reactive oxygen species (ROS). Based on this evidence, the downregulation of seric ADA activity exerts an anti-inflammatory profile, contributing to restricting the inflammatory process. The most important finding is that upregulation of seric XO activity leads to an excessive formation of uric acid, which contributes to oxidative and inflammatory processes. Moreover, uric acid induces the release of pro-inflammatory and pro-oxidative mediators, such NOx and ROS, which contribute directly to disease pathogenesis. In summary, the upregulation of XO activity may be considered a pathway involved in NOx and ROS production in silver catfish infected with I. multifiliis.

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Section: Seric Xo Activity and Uric Acid Levelsmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

Baldissera

Souza

Doleski

et al. 2017

Journal of Fish Diseases

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“…These antioxidant activity levels were markedly lower than those of synthetic antioxidants such as butylated hydroxyanisole [34] and Trolox. [31,35] According to the results, the antioxidant activity of the Z. bungeanum pericarp extracts could be related to the effect of the solvent polarity. This might be attributed to the high number of phenolic compounds in the high-polarity extracts.…”

Section: Antioxidant Activity Of Extractsmentioning

confidence: 99%

Sensory Characteristics and Antioxidant Activity of Zanthoxylum bungeanumMaxim. Pericarps

Wang

et al. 2019

Chemistry & Biodiversity

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In this study, Zanthoxylum bungeanum extracts were prepared using seven solvents: de-ionized water, methanol, ethanol, acetic acid, ethyl acetate, chloroform, and benzene. The volatile compositions in the extracts were qualitatively analyzed using headspace solid-phase microextraction coupled with gas chromatography mass spectrometry detection, and the alkylamide composition was determined using high-performance liquid chromatography. The extract compositions differed with respect to the solvents. A total of 49 volatile components belonging to four groups - terpenoids, alcohols, esters, and ketones -were identified in the extracts. The Z. bungeanum extracts were either ester or terpenoid type, dominated by linalyl acetate. Multivariate analysis divided the extracts into three distinct groups based on principal component analysis and hierarchical clustering analysis. Water, methanol, and ethanol with strongly polarity, could be applied in the food and pharmaceutical industries. This article is protected by copyright. All rights reserved.

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“…During pathological conditions, this enzyme uses molecular oxygen as the electron acceptor and, consequently, produces reactive oxygen species (ROS), which induces pro‐oxidative effects (Peleli et al., ). Recent data have associated the upregulation of XO activity with oxidative stress, due to the formation of excessive uric acid (Doleski et al., ), a molecule with pro‐oxidative effects when present in excess (Perera, Samarasekera, Handunnetti, & Weerasena, ). Also, it has been verified that excessive formation of uric acid by upregulation of XO activity induces the release of pro‐oxidative mediators, such as ROS (Baldissera, Souza, Santos et al., ; Baldissera, Souza, Doleski et al., ).…”

Section: Introductionmentioning

confidence: 99%

Involvement of xanthine oxidase inhibition with the antioxidant property of nanoencapsulated Melaleuca alternifolia essential oil in fish experimentally infected with Pseudomonas aeruginosa

Baldissera

Souza

Doleski

et al. 2018

Journal of Fish Diseases

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Nanoencapsulated Melaleuca alternifolia essential oil (tea tree oil, TTO) is a natural alternative treatment, with 100% therapeutic efficacy in fish experimentally infected with Pseudomonas aeruginosa, and has also potent protective effects linked with antioxidant properties. However, the pathways responsible for the antioxidant capacity remain unknown. Thus, this study evaluated whether the inhibition of seric xanthine oxidase (XO) activity can be considered a pathway involved in the antioxidant capacity of nanoencapsulated TTO in fish experimentally infected with P. aeruginosa. Seric samples from fish infected with P. aeruginosa showed increased XO activity, as well as increased uric acid and reactive oxygen species (ROS) levels. In contrast, the prophylactic treatment with nanoencapsulated TTO prevented these infection-induced alterations. Based on the evidence obtained, the upregulation of seric XO activity induced pro-oxidative effects in the serum of fish experimentally infected with P. aeruginosa, due to excessive formation of uric acid, which stimulates the release of ROS. This treatment was able to prevent the upregulated seric XO activity and, consequently, the excessive formation of uric acid and ROS. In summary, inhibition of seric XO activity can be considered a pathway involved in the antioxidant capacity of nanoencapsulated TTO in fish experimentally infected with P. aeruginosa.

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In vitro anti-inflammatory and anti-oxidant activities of Sri Lankan medicinal plants

Cited by 42 publications

References 47 publications

Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

Serum adenosine deaminase and xanthine oxidase activities in silver catfish naturally infected with Ichthyophthirius multifiliis: The influence of these enzymes on inflammatory and oxidative status

Sensory Characteristics and Antioxidant Activity of Zanthoxylum bungeanumMaxim. Pericarps

Involvement of xanthine oxidase inhibition with the antioxidant property of nanoencapsulated Melaleuca alternifolia essential oil in fish experimentally infected with Pseudomonas aeruginosa

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