In Vitro Anti-Inflammatory Activity of Iridoids and Triterpenoid Compounds Isolated from Phillyrea latifolia L.

Dı́az-Lanza, Ana Marı́a; Abad, María J. F.; Fernández, L.; Recuero, Cristina; Villaescusa, Lucinda; Silván, A. M.; Bermejo, Paulina

doi:10.1248/bpb.23.1307

Cited by 66 publications

(41 citation statements)

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“…These effects were also reported by Matias (2010) for E. pyramidale extract and ointment 0,2%, used in the treatment of 2 nd intention wounds in Wistar rats. The results were also consistent with those described by Diaz et al (2000) who found in experimental models that these acids inhibited the synthesis of prostaglandin E2, similar to indomethacin (CI = 0.95 mM). The ethanol extract, as well as the ointment, was able to reduce leukocyte migration at the expense of neutrophils mostly, which characterized the inhibition of acute inflammatory response (Diaz et al 2000).…”

Section: Discussionsupporting

confidence: 92%

“…The results were also consistent with those described by Diaz et al (2000) who found in experimental models that these acids inhibited the synthesis of prostaglandin E2, similar to indomethacin (CI = 0.95 mM). The ethanol extract, as well as the ointment, was able to reduce leukocyte migration at the expense of neutrophils mostly, which characterized the inhibition of acute inflammatory response (Diaz et al 2000). Regarding the process of re-epithelization, it was noteworthy that in seven days, a tendency to greater re-epithelization was observed in the groups treated with the extract and ointment.…”

Section: Discussionsupporting

confidence: 92%

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Healing effect of the ointment made of Equisetum pyramidale in the treatment of cutaneous lesions in diabetic rats

Corrêa

Filho

Dourado

et al. 2013

Braz. arch. biol. technol.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 92%

Healing effect of the ointment made of Equisetum pyramidale in the treatment of cutaneous lesions in diabetic rats

Corrêa

Filho

Dourado

et al. 2013

Braz. arch. biol. technol.

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“…This beta-carboline alkaloid also has scavenging action on reactive oxygen species and inhibits thiol oxidation (Kim et al, 2001). The analgesic and antiinflammatory activity of ON extract, as found in our study, may be due to either ursolic acid (fraction A), β-sitosterol (fraction B) or harmaline (fraction C) alone or in combination, as ursolic acid isolated from Melaleuca leucadendron inhibit concavalin A induced histamine release (Tsuruga et al, 1991) while the ursolic acid of Phillyrea latifolia inhibit cyclooxygenase and 5-lipooxygenase of arachidonoate cascade (Diaz et al, 2000) and harmala alkaloid of Peganum harmala had antinociceptive activity (Monsef et al, 2004). In conclusion, the results suggest that the traditional medicament Ophiorrhiza nicobarica may offer some beneficial effects in the management of pain and inflammatory conditions.…”

Section: Discussionsupporting

confidence: 53%

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

Chattopadhyay¹,

Das²,

Mandal³

et al. 2007

Oriental Pharmacy and Experimental Medicine

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SUMMARYThis study reports the analgesic, anti-inflammatory and membrane-stabilizing property of alcoholic extract of Ophiorrhiza nicobarica (ON), a wild herb, used as an anti-infective ethnomedicine of Nicobarese and Shompen tribes of Great Nicobar Island, India. We for the first time investigated the analgesic and antiinflammatory potential of this herb in acute, subacute and chronic model of inflammation in Swiss albino mice and Wistar albino rats, along with sheep RBC-induced sensitivity and membrane stabilization. The acetic acid induced writhing, tail flick and tail immersion tests are used as a model for evaluating analgesic activity; while the carrageenin-induced paw oedema was used as the model for acute inflammation, dextran-induced oedema as sub-acute and cotton-pellateinduced granuloma as chronic inflammatory model. The probable mode by which ON mediate its effect on inflammatory conditions was studied on sheep RBC-induced sensitivity and membrane stabilization. The in vitro results revealed that the ON extract possesses significant (P < 0.05) dose dependent analgesic and antiinflammatory activity at 200 and 300 mg/kg and its fractions at 50 mg/ kg, p.o. respectively, compared to the control groups. However, the extract failed to exhibit membrane-stabilizing property as it unable to reduce the level of haemolysis of RBC exposed to hypotonic solution. The acute toxicity studies of ON extract in rats and mice revealed that the extract was nontoxic even up to 3.0 g/kg body weight of the animals, with a high safety profile. We have isolated ursolic acid, β-sitosterol and harmaline respectively, from the bioactive part of the extract. The results indicated that the O. nicobarica is indeed beneficial in primary health care, and suggest that its anti-inflammatory activity may not be related to membrane-stabilization.

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“…It increased coronary blood flow and showed antiarrhythmic and spasmolytic effects. 1,2) Oleuropein exhibited hypoglycemic effect and increased tolerance of orally administered glucose. It also showed anti-oxidative and anti-inflammatory properties.…”

mentioning

confidence: 99%

In Vitro Evaluation of Secoiridoid Glucosides from the Fruits of Ligustrum lucidum as Antiviral Agents.

Deng

et al. 2001

Chem. Pharm. Bull.

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Oleuropein is a phenolic secoiridoid glucoside widespread in members of the family Oleaceae. It has been shown to possess a wide range of biological activities. It increased coronary blood flow and showed antiarrhythmic and spasmolytic effects.1,2) Oleuropein exhibited hypoglycemic effect and increased tolerance of orally administered glucose. It also showed anti-oxidative and anti-inflammatory properties. [3][4][5][6][7] Other reported effects of oleuropein included the potentiation of cellular and organismal protection through the macrophage-mediated response, 4) the inhibition of platelet aggregation and eicosanoid production, 8) reduction of the low density lipoproteins (LDL) level, 9) the potent and protective antioxidant action on LDL, 10) the inhibitory effects on cytochrome P450 and 17b-hydroxysteroid dehydrogenase activity, 11) potent cytotoxic effects on tumor cell lines including P-388, L-1210. 12) inhibitory effects on of lipoxygenase activity, 13) and antibacterial functions. 14-18) Recently, oleuropein was also claimed in a U.S. patent to have potent antiviral activities against herpes mononucleosis, hepatitis virus, rotovirus, bovine rhinovirus, canine parvovirus and feline leukaemia virus. 19) On the other hand, But and his research team recently reported the isolation of oleuropein (4), lucidumoside C (1) and other secoiridoid glucosides from the fruits of Ligustrum lucidum, another member of Oleaceae.3) They demonstrated strong anti-oxidative effects in these secoiridoid glucosides (Table 1). Oleuropein and lucidumoside C were found to have stronger anti-oxidative potency than trolox, their IC 50 being 25.0, 9.3, and 55.0 mM, respectively. Based on such anti-oxidative capabilities and also the antiviral effects claimed in the U.S. patent, the authors suggested that "it would be interesting to check if oleuropein's antiviral effect is related to its anti-oxidant property and also if lucidumoside C has stronger antiviral function". 3)This suggestion actually posed two important questions: 1) is anti-oxidative potency of a compound correlated with its antiviral potency? and 2) is anti-oxidation a mechanism against viruses?In the present paper, we present the in vitro evaluation of six secoiridoid glucosides from the fruits of Ligustrum lucidum against herpes simplex type 1 virus (HSV-1), influenza type A virus (Flu A), respiratory syncytial virus (RSV) and parainfluenza type 3 virus (Para 3). The relationship of antiviral activities of secoiridoid glucosides with their anti-oxidative effects were analysed. Results and DiscussionThe six secoiridoid glucosides isolated from L. lucidum did not show any antiviral activities against Flu A and HSV-1, except oleoside dimethylester (2) which showed a little antiviral activity against HSV-1 (Tables 2, 3).The in vitro antiviral activities of the six isolated compounds against RSV are summarized in Table 4. Oleuropein showed potent anti-RSV activity with an IC 50 value of 23.4 mg/ml and a large therapeutic index comparable to that of ribavirin, an approved d...

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In Vitro Anti-Inflammatory Activity of Iridoids and Triterpenoid Compounds Isolated from Phillyrea latifolia L.

Cited by 66 publications

References 1 publication

Healing effect of the ointment made of Equisetum pyramidale in the treatment of cutaneous lesions in diabetic rats

Healing effect of the ointment made of Equisetum pyramidale in the treatment of cutaneous lesions in diabetic rats

Evaluation of analgesic and antiinflammatory activity of Ophiorrhiza nicobarica, an ethnomedicine from Nicobar Islands, India

In Vitro Evaluation of Secoiridoid Glucosides from the Fruits of Ligustrum lucidum as Antiviral Agents.

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