In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives

Korthikunta, Venkateswarlu; Pandey, Jyotsana; Singh, Rohit; Srivastava, Rohit; Srivastava, Arvind K.; Tamrakar, Akhilesh K.; Narender, Tadigoppula

doi:10.1016/j.phymed.2014.09.007

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…Studies available have reported the beneficial effect of 4-OH-Ile in the control of diabetes and its associated complications. Jaiswal et al ( 2012 ) have reported that 4-OH-Ile (5–25 μM) stimulated glucose uptake in L6-GLUT4 myc myotubes, which has been recently confirmed by Korthikunta et al ( 2015 ). In another study, 4-OH-Ile (10 μM) ameliorated insulin resistance in L6 myotubes (Rawat et al, 2014 ).…”

Section: Methodsmentioning

confidence: 65%

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Mohammed

Islam

2018

Front. Pharmacol.

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Spices possess tremendous therapeutic potential including hypoglycemic action, attributed to their bioactive ingredients. However, there is no study that critically reviewed the hypoglycemic potency, safety and the bioavailability of the spice-derived bioactive ingredients (SDBI). Therefore, the aim of the study was to comprehensively review all published studies regarding the hypoglycemic action of SDBI with the purpose to assess whether the ingredients are potential hypoglycemic agents or adjuvant. Factors considered were concentration/dosages used, the extent of blood glucose reduction, the IC50 values, and the safety concern of the SDBI. From the results, cinnamaldehyde, curcumin, diosgenin, thymoquinone (TQ), and trigonelline were showed the most promising effects and hold future potential as hypoglycemic agents. Conclusively, future studies should focus on improving the tissue and cellular bioavailability of the promising SDBI to achieve greater potency. Additionally, clinical trials and toxicity studies are with these SDBI are warranted.

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Section: Methodsmentioning

confidence: 65%

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Mohammed

Islam

2018

Front. Pharmacol.

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“…4HIL also increased expression of several genes that regulate lipolysis, mitochondrial biogenesis, and glucose uptake in both liver and skeletal muscle including PGC‐1α, PGC‐1β, NRF1, TFAM, and mitofusion1/2 (MFN1/2) in addition to several others in both skeletal muscle and liver of diabetic rats . Isoleucine derivatives illicit similar effects in L6‐glucose transporter 4 (L6‐GLUT4myc) myotubes treated with 4HIL at 5–25μM for 16 hours with increased glucose uptake, likely a byproduct of increased GLUT4 . When the same experimental conditions were repeated with the addition of palmitate, 4HIL restored palmitate‐induced inhibition of glucose uptake and GLUT4 translocation .…”

Section: Molecular Effects Of Bcaasmentioning

confidence: 89%

“…[42] Isoleucine derivatives illicit similar effects in L6-glucose transporter 4 (L6-GLUT4myc) myotubes treated with 4HIL at 5-25μM for 16 hours with increased glucose uptake, likely a byproduct of increased GLUT4. [43,44] When the same experimental conditions were repeated with the addition of palmitate, 4HIL restored palmitate-induced inhibition of glucose uptake and GLUT4 translocation. [44] Reduced insulin signaling as a byproduct of palmitate exposure was shown to be inhibited by 4HIL, specifically via enhanced phosphorylation status of insulin receptor substrate 1 (IRS1), Akt, glycogen synthase kinase 3 beta (GSK3β), and Akt substrate of 160 kDa (AS160).…”

Section: Bcaa-mediated Stimulation Of Cell Metabolismmentioning

confidence: 99%

BCAA Metabolism and Insulin Sensitivity – Dysregulated by Metabolic Status?

Gannon

Schnuck

Vaughan

2018

Molecular Nutrition Food Res

121

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Branched-chain amino acids (BCAAs) appear to influence several synthetic and catabolic cellular signaling cascades leading to altered phenotypes in mammals. BCAAs are most notably known to increase protein synthesis through modulating protein translation, explaining their appeal to resistance and endurance athletes for muscle hypertrophy, expedited recovery, and preservation of lean body mass. In addition to anabolic effects, BCAAs may increase mitochondrial content in skeletal muscle and adipocytes, possibly enhancing oxidative capacity. However, elevated circulating BCAA levels have been correlated with severity of insulin resistance. It is hypothesized that elevated circulating BCAAs observed in insulin resistance may result from dysregulated BCAA degradation. This review summarizes original reports that investigated the ability of BCAAs to alter glucose uptake in consequential cell types and experimental models. The review also discusses the interplay of BCAAs with other metabolic factors, and the role of excess lipid (and possibly energy excess) in the dysregulation of BCAA catabolism. Lastly, this article provides a working hypothesis of the mechanism(s) by which lipids may contribute to altered BCAA catabolism, which often accompanies metabolic disease.

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“…It aff ects all age groups worldwide. The chronic hyperglycemia of diabetes is associated with relatively specifi c long-term microvascular complications aff ecting the heart, eyes, kidneys, and nerves, as well as an increased risk for cardiovascular disease (CVD) [8]. Therefore, a drug having twofold properties, that is, lowering of blood lipids (triglycerides and cholesterol) and glucose together is in great demand [9].…”

Section: Research Articlementioning

confidence: 99%

In Vitro Studies on Alpha-amylase Inhibitory Activities of Zanthoxylum armatum of Mid-Western Regions of Nepal

et al. 2021

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The alpha-amylase inhibitors are used as a drug to control hyperglycemia in type II diabetes mellitus. The plant extract is a natural source to minimize toxicity and other side effects. The alpha-amylase inhibition assay shows that the methanol extracts of fruits, seeds, leaves, and barks of Z. armatum exhibit 50% alpha-amylase inhibition activity at concentration 47.73 μg/mL, 50.25 μg/mL, 67.25 μg/mL, 152.6 μg/mL respectively, and hexane extracts of fruits, seeds, leaves and barks of Z. armatum exhibits 50% alpha-amylase inhibition activity at concentration 86.24 μg/mL, 84.02 μg/mL, 98.8 μg/mL, 138.81 μg/mL respectively, whereas the 50% alpha-amylase inhibition activity of Acarbose (standard) was found to be 33.66 μg/mL. Therefore, methanol and hexane extracts of fruits, seeds, and leaves show potential alpha-amylase inhibition activity and can be used as anti-diabetes.

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In vitro anti-hyperglycemic activity of 4-hydroxyisoleucine derivatives

Cited by 9 publications

References 18 publications

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

Spice-Derived Bioactive Ingredients: Potential Agents or Food Adjuvant in the Management of Diabetes Mellitus

BCAA Metabolism and Insulin Sensitivity – Dysregulated by Metabolic Status?

In Vitro Studies on Alpha-amylase Inhibitory Activities of Zanthoxylum armatum of Mid-Western Regions of Nepal

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