In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action

Asha, M.K.; Debraj, Debnath; D’Souza, Paschal; Edwin, Jothie Richard; Srikanth, H; Nithyanantham, Muruganantham; Dethe, Shekhar; Bhaskar, Anirban; Balachandran, Jaya; Mundkinajeddu, Deepak; Agarwal, Amit

doi:10.1016/j.jep.2012.11.033

Cited by 84 publications

(76 citation statements)

References 34 publications

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“…Besides, the synergy of a ciprofloxacin-pomegranate pericarp extract combination was exhibited against extendedspectrum -lactamase and metallo--lactamase producing Gram-negative bacilli, which was attributed to the bacterial efflux pump inhibitor activity of the polyphenolic constituents of the pomegranate pericarp extract [119]. Some times, multi mechanism was observed for antibacterial activity, a flavonoid rich extract of Glycyrrhiza glabra has exerted anti-H. pylori activity possibly by inhibiting protein synthesis, DNA gyrase and dihydrofolate reductase [120].…”

Section: Mechanismmentioning

confidence: 99%

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Fei¹,

Yang²,

Tang³

et al. 2014

CMC

572

369

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Flavonoids are well known as antibacterial agents against a wide range of pathogenic microorganism. With increasing prevalence of untreatable infections induced by antibiotic resistance bacteria, flavonoids have attracted much interest because of the potential to be substitutes for antibiotics. In this review, the structure-relationship of flavonoids as antibacterial agents is summarized, and the recent advancements on the antibacterial mechanisms of flavonoids are also discussed. It is concluded that hydroxyls at special sites on the aromatic rings of flavonoids improve the activity. However, the methylation of the active hydroxyl groups generally decreases the activity. Besides, the lipopholicity of the ring A is vital for the activity of chalcones. The hydrophobic substituents such as prenyl groups, alkylamino chains, alkyl chains, and nitrogen or oxygen containing heterocyclic moieties usually enhance the activity for all the flavonoids. The proposed antibacterial mechanisms of flavonoids are as follows: inhibition of nucleic acid synthesis, inhibition of cytoplasmic membrane function, inhibition of energy metabolism, inhibition of the attachment and biofilm formation, inhibition of the porin on the cell membrane, alteration of the membrane permeability, and attenuation of the pathogenicity.

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Section: Mechanismmentioning

confidence: 99%

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Fei¹,

Yang²,

Tang³

et al. 2014

CMC

572

369

View full text Add to dashboard Cite

show abstract

“…Asha et al have evaluated Glab and a flavonoid enriched extract of G. glabra (GutGard®, containing ≥ 3.5% w/w of Glab) against different strains of Helicobacter pylori, which is considered as the leading cause of peptic ulcer disease [128]. MICs measured for Glab and GutGard® were 12.5 and 100 μ g/mL, respectively.…”

Section: Reported Biological Activitiesmentioning

confidence: 99%

Phytochemistry and biological properties of glabridin

Simmler¹,

Pauli²,

Chen³

2013

Fitoterapia

213

150

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Glabridin, a prenylated isoflavonoid of G. glabra L. roots (European licorice, Fabaceae), has been associated with a wide range of biological properties such as antioxidant, anti-inflammatory, anti-atherogenic, regulation of energy metabolism, estrogenic, neuroprotective, anti-osteoporotic, skin-whitening. While glabridin is one of the most studied licorice flavonoids, a comprehensive literature survey linked to its numerous bioactivities is unavailable. The present review provides a comprehensive description of glabridin as a key chemical and biological marker of G. glabra, by covering both its phytochemical characterization and reported biological activities. Both glabridin and standardized licorice extracts have significant impact on food, dietary supplements (DSs) and cosmetic markets, as evidenced by the amount of available patents and scientific articles since 1976, when glabridin was first described. Nevertheless, a thorough literature survey also reveals that information about the isolation and chemical characterization of this important marker is scattered and less detailed than expected. Accordingly, the first part of this review gathers all analytical and spectroscopic data required for the comprehensive phytochemical characterization of glabridin. The four most frequently described and most relevant bioactivities of glabridin are its anti-inflammatory, anti-atherogenic, estrogenic-like effects, and its capacity to regulate energy metabolism. While all bioactivities reported for glabridin belong to a wide array of targets, its principal biological properties are likely interconnected. To this end, the current state of the literature suggests that the biological activity of glabridin mainly results from its capacity to down-regulate intracellular reactive oxygen species, bind to antioxidant effectors, and act on estrogen receptors, potentially as a plant-based Selective Estrogen Receptor Modulator (phytoSERM).

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“…18 Additionally, some flavonoids are known to be antibacterial agents. 19 For example, the flavonoid-rich extract of Glycyrrhiza glabra inhibited H. pylori growth by inhibition of protein synthesis, DNA gyrase and dihydrofolate reductase 10 , while the flavonoid fraction of C. erythraeum was not active against examined strains, which may be presumably due to the difference in the flavonoid constituents of the plants and/or the susceptibility of bacteria. Whereas in this study, the hexane extract of the plant mainly inhibited the H. pylori strains attributed to the presence of non-polar compounds.…”

Section: Resultsmentioning

confidence: 99%

Chemical constituents of cymbocarpum erythraeum (dc.) boiss., and evaluation of its anti-helicobacter pylori activity

Heidari

Manayi

Saeidnia

et al. 2018

tjps

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Objective: Cymbocarpum erythraeum (Apiaceae) is an endemic species in Iran. Up to now, there have been no phytochemical and biological investigations on this species. Therefore, isolation of the main secondary metabolites of the plant along with its anti-H. pylori activity have been considered in this paper. Materials and Methods:The dried parts of the plant were extracted with different solvents using solvent percolation and the antibacterial activity of the extracts evaluated by the disk diffusion method. Four compounds were isolated using different column chromatography methods. Results:The compounds were identified by proton nuclear magnetic resonance and carbon-13 nuclear magnetic resonance as isoquercetin (1), rutin (2), β-sitosterol (3) and 2-decenol (4). Conclusion:Anti-H. pylori evaluation of the extracts and isolated compounds against three clinical isolates of H. pylori revealed that hexane extract of the plant inhibited all H. pylori strains. Amaç: Cymbocarpum erythraeum (Apiaceae) İran'a endemik bir türdür. Bu zamana kadar, bu tür üzerinde herhangi bir fitokimyasal ve biyolojik aktivite çalışmasına rastlanmamıştır. Bu nedenle, bu çalışmada, bitkinin ana sekonder metabolitlerinin ve Helicobacter pylori'ye karşı etkisinin araştırılması amaçlanmıştır. Gereç ve Yöntemler: Kurutulmuş bitki kısımları perkolasyon yöntemi ile farklı çözücüler kullanılarak ekstre edilmiş ve ekstrelerin antibakteriyel etkisi disk difüzyon yöntemiyle değerlendirilmiştir. Farklı kolon kromatografisi yöntemleri kullanılarak dört bileşik izole edilmiştir. Bulgular: Bileşiklerin yapıları, proton nükleer manyetik rezonans ve karbon-13 nükleer manyetik rezonans tekniği ile izokersetin (1), rutin (2), β-sitosterol (3) ve 2-dekenol (4) olarak belirlenmiştir. Sonuç: Ekstrelerin ve izole edilen bileşiklerin üç H. pylori klinik izolatına karşı etkilerinin değerlendirildiği bu çalışmada, bitkinin hekzan ekstresinin tüm H. pylori suşlarını ihibe ettiği tespit edilmiştir.

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In vitro anti-Helicobacter pylori activity of a flavonoid rich extract of Glycyrrhiza glabra and its probable mechanisms of action

Cited by 84 publications

References 34 publications

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Antibacterial Activities of Flavonoids: Structure-Activity Relationship and Mechanism

Phytochemistry and biological properties of glabridin

Chemical constituents of cymbocarpum erythraeum (dc.) boiss., and evaluation of its anti-helicobacter pylori activity

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