In vitro anti-demodectic effects and terpinen-4-ol content of commercial eyelid cleansers

Cheung, Isabella M.Y.; Xue, Ally L.; Kim, Andy D; Ammundsen, Kirsty; Wang, Michael T.M.; Craig, Jennifer P.

doi:10.1016/j.clae.2018.08.003

Cited by 30 publications

(31 citation statements)

References 33 publications

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“…122 An increasing number of eyelid hygiene products are available to manage Demodex infestation, 123,124 containing either TTO or T4O with varying concentrations. 15,107,125 Linalool, an alcohol which is the primary component of rosewood (Aniba rosaeodora) and Camphor tree (Cinamomon camphora) oils, have also been found to have a strong antimicrobial property including leishmanicidal effects. 126 Lid hygiene products containing TTO, T4O, linalool or a combination of these all reduce Demodex survival time, although the efficacy of linalool alone warrants further investigation.…”

Section: Managementmentioning

confidence: 99%

Demodex and eye disease

Bitton

Aumond

2021

Clinical and Experimental Optometry

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Demodex is the most common parasite living on humans and yet little is understood about its pathogenicity with respect to the ocular surface. An increasing interest in Demodex over the past 20years has increased our understanding of this mite and its pathogenetic role. This article begins with a review of the anatomy, life cycle, mode of transmission and advances in genetics that can distinguish between Demodex folliculorum and Demodex brevis, the only two Demodex species in humans. Additionally, a review of diagnostic procedures and existing and emerging ocular and systemic management options are presented. Despite the increasing interest in Demodex in the literature, there remains numerous obstacles for future studies, hence a section of this review is dedicated to the identification and proposal for future considerations. The lack of uniformity with respect to terminology, diagnostic technique and management approach for Demodex remain as obstacles for future study comparisons. This review summarised the current knowledge on Demodex and hopes to offer some recommendations for future directions in the study of Demodex in humans.

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Section: Managementmentioning

confidence: 99%

Demodex and eye disease

Bitton

Aumond

2021

Clinical and Experimental Optometry

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“…Significant growth inhibitor of colorectal, pancreatic, prostate and gastric cancer cells. Shapira et al 2016, Bordini et al 2018, Cheung et al 2018 Sabinene Strong antioxidant activity and antibacterial activity against Escherichia coli. Sharma et al 2019 Limonene Antiviral, anti-inflammatory, and antibacterial.…”

Section: Bornyl Acetatementioning

confidence: 99%

Endemic Juniperus gracilior varieties of the Hispaniola island, tree taxa of environmental and economic relevance and a valuable phytochemical source

et al. 2021

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The Juniperus genus has long been used and studied for the chemical components of its aerial parts (leaves, bark, twigs) and their bioactivity. Nevertheless, these studies and their compilation have been primarily focused on Europe and North America distributed taxa, leaving the knowledge and economic potential of the endangered Caribbean taxa highly underrepresented in the literature. Although, these conifers have been barely investigated for their bioactive compounds, bibliography does indicate the presence of potent antitumoral, anti-inflammatory and antimicrobial molecules such as deoxypodophyllotoxin, podophyllotoxin, amentoflavone and widdrol. Additional phytochemical potential can also be inferred from the systematical essential oil studies of the taxa, the only source of chemical composition information on most of them. These investigations can aid in the narrowing down of the possible bioactivities their lipidic extracts may possess, while also providing clues for the bioassays necessary to confirm them. This review aims to compile the known information on the usage, bioactivity and chemical composition of the Hispaniolian J. gracilior varieties and their phylogenetically proximal taxa (J. gracilior var. saxicola, J. barbadensis and J. bermudiana), to propitiate more holistic and in depth chemical studies on these potential phytochemical sources, in turn providing an economical incentive for their conservation.

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“…There are Cliradex (Bio-Tissue) wipes available on the market, recommended for regular cleaning of the edges of the eyelids and eyelashes, in the case of mild or moderate demodecosis, containing 4 or 10% T4O, and preparations containing 50% T4O [15,17]. Cheung et al [20] in an in vitro study compared the anti-demodicosis effect of four agents used for cleaning the eyelids: Cliradex (Bio-Tissue), Blephadex, Oust Demodex and SteriLid (Theratears). Clidarex as the only one of the abovementioned preparations showed antiparasitic activity comparable to the activity of 50% of TTO.…”

Section: Essential Oils and Demodicosismentioning

confidence: 99%

Activity of Plant Essential Oils Against Demodex folliculorum and Demodex brevis

Wróblewska

Nuszkiewicz

Wróblewski

et al. 2020

PNIN

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Infestation with Demodex spp. is an increasingly common dermatological and ophthalmic problem. Preparations for daily cleaning of eyes and the surrounding area (gels, soaked wipes) contain mainly tea tree oil or terpinen-4-ol. To date, the use of other essential oils supporting the fight against demodicosis is limited due to insufficient number of clinical trials. The aim of this review is to present the most commonly used medicinal plants and their active ingredients used in the treatment of infestation with Demodex folliculorum and Demodex brevis, with particular emphasis on tea tree oil. PubMed, Embase and Google Scholar databases were searched for the selection of scientific literature. (JNNN 2020;9(4):160–165) Key Words: Demodex brevis, Demodex folliculorum, essential oil, parasitic disease, tea tree oil

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In vitro anti-demodectic effects and terpinen-4-ol content of commercial eyelid cleansers

Cited by 30 publications

References 33 publications

Demodex and eye disease

Demodex and eye disease

Endemic Juniperus gracilior varieties of the Hispaniola island, tree taxa of environmental and economic relevance and a valuable phytochemical source

Activity of Plant Essential Oils Against Demodex folliculorum and Demodex brevis

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