In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts of Moringa oleifera Plants from Rivers State, Niger Delta, Nigeria

Nwidu, Lucky Legbosi; Elmorsy, Ekramy; Aprioku, Jonah Sydney; Siminialayi, IM; Carter, Wayne Grant

doi:10.3390/medicines5030071

Cited by 34 publications

(31 citation statements)

References 69 publications

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“…Likewise, the amount of total flavonoids among the aqueous and ethanol extract of dried leaves of M.oleifera, the ethanol based extract revealed the maximum amount of total flavonoids (6.20 g isoquercetin equivalents/100 g extract) 44 . Our result was in close agreement with this findings revealed that leaves of M.oleifera for total flavonoids of 61.618 mg/gm of dry 3) and ethanolic leaf (69.7 -342.5) extract revealed significant amount of total flavonoids than the aqueous extract (27.0-87.2 mg QUER E/g) 45 . Sulaiman Mohammed and Fazilah Abd Manan (2015) revealed the total flavonoid content from the seeds of moringa was 2.900 ± 0.0002 (mg Quercetin equivalents /g dry matter) 46 which was very similar to our results.…”

Section: Estimation Of Total Flavonoids (Antioxidants)supporting

confidence: 93%

Nutritional and Anti Oxidant Potential of Commonly Growing Plant Foods from Southern India

et al. 2020

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Certain varieties of plants are abundantly available with rich in nutrients, but the complete sets of nutritional composition studies have not been carried out. Among them, the matured leaves of Murrya keonigii; seeds and leaves of Moringa oleifera, and fruit pulp of Aegle marmelos were chosen. The proximate analysed for above samples showed that the moisture varies from 2.4% -8.2%, crude proteins from 18.75%- 34.57 %, fat content from 5.6% -19.6%, ash content from 3.87%-15.6% and carbohydrate from 28.65% - 41.23%, respectively. Estimation of mineral contents revealed that the leaves and seeds of moringa had higher concentrations than others. Determination of total antioxidant (total flavonoid) was higher (63.550 μg (RU)/ml of samples) in matured curry leaves than others. Determination of in vitro antioxidant activity with FRAP revealed highest activity in curry leaves (174.5μg) to a least activity with seeds of moringa (45.725 μg), whereas the DPPH revealed highest activity for fruit pulp of bael (1680.6μg ascorbic acid) to the least in leaves of moringa (263.15 μg ascorbic acid equivalent/mg). The ABTS showed IC50 value of 210.52 ±0.5774 for curry leaf, 487.8 ±0.3347 and 205.36 moringa seeds and leaves and 513.24 IC50 μg for pulp of bael fruit. Quantitative analysis of water soluble vitamins such as thiamine (B1) varied from 2.172 -5.558 mg; riboflavin (B2) from 2.201 -11.354 mg; pyridoxine (B6) from 4.608 -194.001 mg; biotin (B7) from 36.864 -153.027 mg, respectively. Further, the vitamin C (ascorbic acid) varied from 6.733 -23.142 mg /100g of oven dried samples, respectively. Therefore, the above foods are well intended to be included in routine diet regime and may also be willing to utilise for food supplementation with other suitable diets to manage the conditions such as malnutrition and nutrient deficiencies.

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Section: Estimation Of Total Flavonoids (Antioxidants)supporting

confidence: 93%

Nutritional and Anti Oxidant Potential of Commonly Growing Plant Foods from Southern India

et al. 2020

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“…Compared with this study, the seeds from both Kenya and Nigeria had the lowest TFC, while the TFC of leaves was higher than roots in Kenya and the opposite occurred in Nigeria. The differences may be caused by the differences in climate and soil compositions of the different growing areas [36,37].…”

Section: Resultsmentioning

confidence: 99%

Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of Moringa oleifera from Kenya and Their Correlations with Flavonoids

Chen

2019

Antioxidants

131

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Moringa oleifera Lam. (M. oleifera) is commonly distributed and utilized in tropical and sub-tropical areas. There has been a large number of reports on the antioxidant and anti-inflammatory activity of its leaves, but only a few about its seeds and roots. Hence, in this work we aimed to systematically compare the antioxidant and anti-inflammatory activities of the ethanol crude extracts of leaves, seeds, and roots of M. oleifera from Kenya, and further correlate the differential activities with the chemical constituents from these three parts. The antioxidant activities were measured by using three different assays (DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2′-azinobis-(3-ethylbenzthiazoline-6-sulfonic acid) and FRAP (Ferric-Reducing Antioxidant Power), respectively). Results showed that the leaf extracts displayed the highest DPPH radical scavenging and FRAP total reducing power activities with IC50 values of 1.02 ± 0.13 mg/mL and 0.99 ± 0.06 mM Fe2+/g, respectively; the leaf and root extracts exhibited potential ABTS radical scavenging activities with the IC50 values of 1.36 ± 0.02 and 1.24 ± 0.03 mg/mL. Meanwhile, the leaf and seed extracts (11.1–100 µg/mL) also exerted obvious anti-inflammatory activities, as indicated by the inhibition of NO production. To further reveal correlations between these differential activities with the chemical constituents in the three organs, the total flavonoids content (TFC) of the three different extracts were evaluated, and the TFC of leaves, seeds and roots were found to be 192.36 ± 2.96, 5.89 ± 0.65 and 106.79 ± 2.12 mg rutin equivalent (RE)/g, respectively. These findings indicated the important impacts of the total flavonoid contents on antioxidant and anti-inflammatory activities. Additionally, we further determined the phytochemical profiles of M. oleifera by HPLC-UV/ESI-MS/MS, and identified most of the chemical constituents of leaves as flavonoids. In summary, the leaves of M. oleifera are a better potential natural source of antioxidants and anti-inflammatory agents, and very promising for development into the health promoting dietary supplements.

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“…Among the analyzed samples, four of them (samples 5, 10, 11 and 13) have got the lowest values of AChE inhibitory activity. This could be explained by a lower content of polyphenolic compounds [36,37] and lower antioxidant activity among the analyzed water extracts [38]. The standards (gallic acid, caffeic acid, rutin, and ascorbic acid) also did not show any significant AChE inhibitory activity.…”

Section: Resultsmentioning

confidence: 99%

A Comparative Study on the Phenolic Composition and Biological Activities of Morus alba L. Commercial Samples

et al. 2019

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Morus alba L. (white mulberry) has been commonly used as a functional food and for medicinal purposes. Hence, the aim of the study was to compare the phenolic profile of white mulberry commercial samples in relation to their antioxidant potential and acetylcholinesterase (AChE) inhibitory activity. It is of interest to determine whether herbal products originating from different commercial sources differ in their phenolic profiles. For this purpose, a simple and rapid high-performance liquid chromatography (HPLC) method was used for the separation and determination of ten major phenolic compounds. Total phenolic (TPC), total flavonoid (TFC), and total phenolic acid contents (TPAC), as well as l(+)-ascorbic acid (ASA) contents, were determined. The antioxidant potential was assessed by DPPH (2,2-diphenyl-1-picrylhydrazyl radical) scavenging activity and ferric-reducing/antioxidant power (FRAP) assay, while the AChE inhibitory activity was determined by the Ellman assay for water extracts. The study revealed that excluding two herbal products containing fruits and a sample containing leaves of white mulberry, yerba mate and lemon, the remaining samples were generally consistent in terms of phenolic composition as well as antioxidant potential and AChE inhibitory activity. This reflects the health-promoting properties of the samples under study. Moreover, the results showed that the water extracts of white mulberry were richer in phenolic compounds and presented higher antioxidant activity than the hydromethanolic extracts. However, the water extracts showed low inhibitory activity against AChE. Moreover, the correlation analysis indicated a high positive relationship between phenolic composition and antioxidant activity in extracts of white mulberry. Overall, the obtained results may be useful in the evaluation of new dietary supplements and food products. The water extracts of white mulberry could be used for antioxidant purposes, while the hydromethanolic extracts could be incorporated in antioxidant formulations.

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In Vitro Anti-Cholinesterase and Antioxidant Activity of Extracts of Moringa oleifera Plants from Rivers State, Niger Delta, Nigeria

Cited by 34 publications

References 69 publications

Nutritional and Anti Oxidant Potential of Commonly Growing Plant Foods from Southern India

Nutritional and Anti Oxidant Potential of Commonly Growing Plant Foods from Southern India

Antioxidant and Anti-Inflammatory Activities of the Crude Extracts of Moringa oleifera from Kenya and Their Correlations with Flavonoids

A Comparative Study on the Phenolic Composition and Biological Activities of Morus alba L. Commercial Samples

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