In vitro andin vivo percutaneous absorption of benzo[a]pyrene from petroleum crude-fortified soil in the rat

Yang, Jimmy; Roy, Timothy A.; Krueger, Andrew J.; Neil, William; Mackerer, Carl R.

doi:10.1007/bf01701749

Cited by 72 publications

(58 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The in vivo animal studies which relate specifically to PAH dermal bioavailability from soils have used monkeys, rats and guinea pigs (Yang et al, 1989;Wester et al, 1990;Turkall et al, 1994;Kadry et al, 1995;Moody et al, 1995;Roy et al, 1998a). These tests take the general form of applying the test chemical to a designated area of skin in an appropriate vehicle (for the purposes of this review this is soil).…”

Section: Animal Exposurementioning

confidence: 99%

“…Human skin is, however, not always easily available and a number of studies have used alternative animal skins. In studies where PAH dermal bioavailability, with and without soil have been studied (Wester et al,, 1990;Moody et al, 1995;Roy et al,, 1998b;Roy and Singh, 2001;Moody et al, 2007;Moody et al, 2009;Moody et al, 2011), pig (Jacques et al, 2010), rat (Yang et al, 1989;Moody et al, 1995;Roy et al, 1998a) and guinea pig skin (Moody et al, 1995) have been used.…”

Section: In Vitro Membrane Types Usedmentioning

confidence: 99%

“…Key dermal bioavailability studies for PAH in soil are discussed with key points summarised in Table 1 ( Yang et al,, 1989;Wester et al, 1990;Moody et al, 1995;Roy et al, 1998a;Roy et al, 1998b;Riviere et al, 1999;Roy and Singh, 2001;Abdel-Rahman et al, 2002;Moody et al, 2007;Moody et al, 2009;Jacques et al, 2010;Moody et al, 2011). .…”

Section: Key In Vitro Dermal Bioavailability Studiesmentioning

confidence: 99%

“…This guidance was used in the Yang et al (1989) study of in vitro BaP dermal bioavailability on rat skin with a loading rate of 9 mg cm -2…”

Section: Equation 6 -Formula To Calculate a Soil Monolayermentioning

confidence: 99%

“…In addition to the total exposure time, some studies take multiple intermediate measurements (Yang et al, 1989;Turkall et al, 1994;Roy et al,, 1998b;Roy and Singh, 2001;Abdel-Rahman et al, 2002;Moody et al, 2011), whilst others make a single measurement at the end time of the experiment (Wester et al, 1990;Moody et al, 2007). There does not appear to be any standardised approach to make the measurement at specific end-point i.e.…”

Section: Equation 6 -Formula To Calculate a Soil Monolayermentioning

confidence: 99%

See 4 more Smart Citations

A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

Beriro

Cave

Wragg

et al. 2016

Journal of Hazardous Materials

View full text Add to dashboard Cite

Polycyclic Aromatic Hydrocarbons are classed as Persistent Organic Pollutants, a large group of compounds that share similar characteristics. They are lipophilic, resistant to degradation in the environment and harmful to human and environmental health. Soil has been identified as the primary reservoir for Polycyclic Aromatic Hydrocarbons in the United Kingdom. This study reviews the literature associated with, or is relevant to, the measurement and modelling of dermal absorption of Polycyclic Aromatic Hydrocarbons from soils. The literature illustrates the use of in vivo, in vitro and in silico methods from a wide variety of scientific disciplines including occupational and environmental exposure, medical, pharmaceutical and cosmetic research and associated mathematical modelling. The review identifies a number of practical shortcomings which must be addressed if they are to be applied to high throughput laboratory analysis of contaminated soils for human health risk assessment.

show abstract

Section: Animal Exposurementioning

confidence: 99%

Section: In Vitro Membrane Types Usedmentioning

confidence: 99%

Section: Key In Vitro Dermal Bioavailability Studiesmentioning

confidence: 99%

“…This guidance was used in the Yang et al (1989) study of in vitro BaP dermal bioavailability on rat skin with a loading rate of 9 mg cm -2…”

Section: Equation 6 -Formula To Calculate a Soil Monolayermentioning

confidence: 99%

Section: Equation 6 -Formula To Calculate a Soil Monolayermentioning

confidence: 99%

See 3 more Smart Citations

A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

Beriro

Cave

Wragg

et al. 2016

Journal of Hazardous Materials

View full text Add to dashboard Cite

show abstract

Chemical and biological availability of sediment‐sorbed benzo[a]pyrene and hexachlorobiphenyl

Schuler

Lydy

2001

Enviro Toxic and Chemistry

View full text Add to dashboard Cite

This study examined the chemical and biological availability of two nonpolar organic compounds, benzo[a]pyrene (BaP) and hexachlorobiphenyl (HCBP), from a spiked sediment that was aged for varying amounts of time. Chemical availability was evaluated using four different solvent combinations to extract chemicals from the sediment. The extractability of BaP and HCBP from sediment using traditional solvents was then compared to the transfer efficiency (TE) of a benthic invertebrate (Lumbriculus variegatus) to relate chemical extractability to bioavailability in the organisms. Results indicated that water was the solvent that best approximated bioavailability for BaP, whereas comparisons for HCBP were inappropriate, because TE values exceeded 100%. The inability to obtain a reasonable TE estimate for HCBP was most likely due to the fact that the oligochaetes received a major portion of their uptake from interstitial water instead of ingestion of sediment particles, which invalidated an important assumption of the TE model. Overall, the results of this study indicate that exhaustive chemical extractions may be an inaccurate representation of the bioavailable fractions for some contaminants.

show abstract

Dermal absorption of polycyclic aromatic hydrocarbons in the blood‐perfused pig ear

Vanrooij

Vinke

Lange³

et al. 1995

J of Applied Toxicology

View full text Add to dashboard Cite

Urinary 1-OH-pyrene, a metabolite of pyrene, is a sensitive biological marker for dermal absorption of pyrene in man. In order to determine whether this metabolite is a reliable biomarker of cutaneous absorption of other polycyclic aromatic hydrocarbons (PAHs), the blood-perfused pig ear model was used to compare the dermal absorption flux of pyrene with nine other PAHs after coal tar application. Cumulative absorption of PAHs into the perfusion blood, 200 min after application of an overdose of coal tar, ranged between 830 pmol cm-2 for phenanthrene to less than 4 pmol cm-2 for benzo[b]fluoroanthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenzo[ah]anthracene and indeno[123-cd]pyrene. The results of this study show that when pyrene is used as a marker compound for PAH absorption through pig skin, the cumulative absorption of PAHs with a lower molecular weight will be underestimated: fluorene, tenfold; phenanthrene, 12-fold; anthracene and fluoranthene, ca. twofold. The percutaneous absorption of PAHs with a higher molecular weight than pyrene will be overestimated: e.g. benzo[a]pyrene, sevenfold; indeno [123-cd]pyrene, ca. 100-fold. It is likely that this conclusion is also valid for dermal PAH absorption in man.

show abstract

In vitro andin vivo percutaneous absorption of benzo[a]pyrene from petroleum crude-fortified soil in the rat

Cited by 72 publications

References 13 publications

A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

A review of the current state of the art of physiologically-based tests for measuring human dermal in vitro bioavailability of polycyclic aromatic hydrocarbons (PAH) in soil

Chemical and biological availability of sediment‐sorbed benzo[a]pyrene and hexachlorobiphenyl

Dermal absorption of polycyclic aromatic hydrocarbons in the blood‐perfused pig ear

Contact Info

Product

Resources

About