In vitro and in vivo assessment of indomethacin-induced genotoxicity: protection by curcumin
Ehsan Zamani,
Reza Alipour Klour,
Amirreza Gholami Shekarsarayi
et al.
Abstract:Background and purpose:
Indomethacin is one of the most widely used non-steroidal anti-inflammatory drugs. This study aimed to investigate the protective effects of curcumin against indomethacin-induced genotoxicity.
Experimental approach:
For in vitro studies, human peripheral blood lymphocytes were obtained from a healthy volunteer and treated for 24 h as follows: vehicle control, indomethacin at 100 and 200 μΜ, indomethacin (100 μM and 200 μM) plus c… Show more
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