In vitro and in vivo evaluation of poly-3-hydroxybutyric acid-sodium alginate as a core-shell nanofibrous matrix with arginine and bacitracin-nanoclay complex for dermal reconstruction of excision wound

Shiny, Punalur John; Devi, Mohan Vimala; Felciya, Sekar Jeyakumar Grace; Ramanathan, Giriprasath; Fardim, Pedro; Uma, T.

doi:10.1016/j.ijbiomac.2020.12.025

Cited by 20 publications

(11 citation statements)

References 49 publications

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“…In addition to a positive control with Bacitracin that were used in a wound healing assay. 95 Wound contraction treated with the films was significantly (p > 0.05) higher compared to the control group. On the 12th day of treatment, 63% and 96% contractions were observed for the control and PA-SLB groups, respectively.…”

Section: Wound Healing Activity Of Alginate/pva Composite Filmsmentioning

confidence: 80%

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Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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The skin is the largest organ in the human body and its physical integrity must be maintained for body homeostasis and to prevent the entry of pathogenic microorganisms. Sodium alginate (SA) and polyvinyl alcohol (PVA) are two polymers widely used in films for wound dressing applications. Furthermore, blends between SA and PVA improve physical, mechanical and biological properties of the final wound healing material when compared to the individual polymers. Different drugs have been incorporated into SA/PVA-based films to improve wound healing activity. It is noteworthy that SA/PVA films can be crosslinked with Ca 2+ or other agents, which improves physicochemical and biological properties. Thus, SA/PVA associations are promising for the biomedical field, as a potential alternative for wound treatment. This review focuses on the main techniques for obtaining SA/PVA films, their physical-chemical characterization, drug incorporation, and the advantages and challenges of these films for wound healing.

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Section: Wound Healing Activity Of Alginate/pva Composite Filmsmentioning

confidence: 80%

“…103 The use of electrospinning with pure alginate requires combinations with other polymers such as PVA for adequate electrospinning. 95…”

Section: Challengesmentioning

confidence: 99%

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

et al. 2022

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“…Other applications of LDHs in tissue engineering are summarized in Table 3. 463–476 However, further research effort should be devoted to evaluating the clinical application of LDHs in regenerative medicine comprehensively.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Layered double hydroxide-based nanomaterials for biomedical applications

et al. 2022

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“…The fabricated trilayer hybrid membrane exhibited significant antibacterial activity against Staphylococcus aureus and E. coli , and high absorbent properties, verifying its potential as a wound dressing material [ 48 ]. Electrospun alginate nanofibers encapsulating various antimicrobial agents have shown enhanced antibacterial activity, accelerating the healing process [ 49 , 50 ]. Zhu et al (2016) developed core–shell electrospun nanofibers of chitosan/asiaticoside and alginate/PVA that served as the core and the shell, respectively, to evaluate their effectiveness in the treatment of burn injuries.…”

Section: Seaweed-derived Biopolymersmentioning

confidence: 99%

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

et al. 2022

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Marine biopolymers, abundantly present in seaweeds and marine animals, feature diverse structures and functionalities, and possess a wide range of beneficial biological activities. Characterized by high biocompatibility and biodegradability, as well as unique physicochemical properties, marine biopolymers are attracting a constantly increasing interest for the development of advanced systems for applications in the biomedical field. The development of electrospinning offers an innovative technological platform for the production of nonwoven nanofibrous scaffolds with increased surface area, high encapsulation efficacy, intrinsic interconnectivity, and structural analogy to the natural extracellular matrix. Marine biopolymer-based electrospun nanofibrous scaffolds with multifunctional characteristics and tunable mechanical properties now attract significant attention for biomedical applications, such as tissue engineering, drug delivery, and wound healing. The present review, covering the literature up to the end of 2021, highlights the advancements in the development of marine biopolymer-based electrospun nanofibers for their utilization as cell proliferation scaffolds, bioadhesives, release modifiers, and wound dressings.

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In vitro and in vivo evaluation of poly-3-hydroxybutyric acid-sodium alginate as a core-shell nanofibrous matrix with arginine and bacitracin-nanoclay complex for dermal reconstruction of excision wound

Cited by 20 publications

References 49 publications

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Alginate/polyvinyl alcohol films for wound healing: Advantages and challenges

Layered double hydroxide-based nanomaterials for biomedical applications

Marine Biopolymers as Bioactive Functional Ingredients of Electrospun Nanofibrous Scaffolds for Biomedical Applications

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