In vitro and in vivo corrosion and histocompatibility of pure Mg and a Mg-6Zn alloy as urinary implants in rat model

Zhang, Shiying; Zheng, Yang; Zhang, Liming; Bi, Yanze; Li, Jianye; Liu, Jiao; Yu, Youbin; Guo, Heqing

doi:10.1016/j.msec.2016.06.017

Cited by 60 publications

(25 citation statements)

References 40 publications

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“…In addition, pathological analysis demonstrated that the in vivo degradation of Mg6Zn alloy did not harm the vital organs (heart, liver, kidney, and spleen) [278]. Guo et al [60] have also studied the in vitro and in vivo histocompatibility of urinary implants made of Mg6Zn and pure Mg. The Mg6Zn alloy degrades faster than pure Mg in SBF, but exhibits better Up to now, Mg-Zn based alloys have not been commercialized for clinical/medical applications, but a relatively high number of in vivo and in vitro studies have been carried out to investigate the feasibility of Mg-Zn based alloys as biomedical materials.…”

Section: Applications Of Mg-zn Based Alloysmentioning

confidence: 99%

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Jiang

Blawert

Zheludkevich

2020

CMD

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Magnesium alloys have shown great potential for applications as both structural and biomedical materials due to their high strength-to-weight ratio and good biodegradability and biocompatibility, respectively. Among them, Mg-Zn based alloys are attracting increasing interest for both applications. As such, this article provides a review of the corrosion performance and mechanical properties of Mg-Zn based alloys, including the influence of environment and processing on both of them. The strategies for tailoring corrosion resistance and/or mechanical properties by microstructure adjustment and surface treatment are discussed.

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Section: Applications Of Mg-zn Based Alloysmentioning

confidence: 99%

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Jiang

Blawert

Zheludkevich

2020

CMD

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“…Highly porous materials corrode very rapidly, as a larger area of the material surface is exposed to the corrosion environment. Corrosion resistance of either pure magnesium or magnesium alloys is seldom suitable for technical applications or even biomedical applications [3,9,[16][17][18][19][20]. Magnesium corrosion resistance can be improved by alloying the metal with aluminum, zinc or rare earth metal elements; however, for significantly better corrosion resistance, another way of reducing the degradation rate must be considered.…”

Section: Introductionmentioning

confidence: 99%

“…Conversion coatings are widely studied as corrosion protection for magnesium and its alloys. Fluoride and calcium phosphate-based conversion coatings have a great potential of reducing the corrosion rate of biomedical magnesium implants [1][2][3][4][12][13][14][15][16][17][18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Zapletal

Březina

Krystýnová

et al. 2017

Metals

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Magnesium with its mechanical properties and nontoxicity is predetermined as a material for biomedical applications; however, its high reactivity is a limiting factor for its usage. Powder metallurgy is one of the promising methods for the enhancement of material mechanical properties and, due to the introduced plastic deformation, can also have a positive influence on corrosion resistance. Pure magnesium samples were prepared via powder metallurgy. Compacting pressures from 100 MPa to 500 MPa were used for samples' preparation at room temperature and elevated temperatures. The microstructure of the obtained compacts was analyzed in terms of microscopy. The three-point bending test and microhardness testing were adopted to define the compacts' mechanical properties, discussing the results with respect to fractographic analysis. Electrochemical corrosion properties analyzed with electrochemical impedance spectroscopy carried out in HBSS (Hank's Balanced Salt Solution) and enriched HBSS were correlated with the metallographic analysis of the corrosion process. Cold compacted materials were very brittle with low strength (up to 50 MPa) and microhardness (up to 50 HV (load: 0.025 kg)) and degraded rapidly in both solutions. Hot pressed materials yielded much higher strength (up to 250 MPa) and microhardness (up to 65 HV (load: 0.025 kg)), and the electrochemical characteristics were significantly better when compared to the cold compacted samples. Temperatures of 300 • C and 400 • C and high compacting pressures from 300 MPa to 500 MPa had a positive influence on material bonding, mechanical and electrochemical properties. A compacting temperature of 500 • C had a detrimental effect on material compaction when using pressure above 200 MPa.

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“…electrochemical deposition [15,16], polymer treatment [17,18], chemical deposition [19,20], and micro-arc oxidation (MAO) techniques [21][22][23], have been introduced to improve the degradation rate and bioactivity of magnesium and its alloys [9,24]. As is known, fabrication of magnesium-based composites with bio-ceramic additives [25], besides the surface modification of magnesium implants, and alloying magnesium with biocompatible metals [26,27] are the major techniques to protect the implant from fast corrosion and degradation in vivo. Moreover, bio-additives and suitable coatings can improve the hemocompatibility and bioactivity of implants in this field [11,14,[28][29][30][31].…”

Section: Introductionmentioning

confidence: 99%

Biodegradable Mg/HA/TiO2 Nanocomposites Coated with MgO and Si/MgO for Orthopedic Applications: A Study on the Corrosion, Surface Characterization, and Biocompatability

et al. 2017

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Abstract:In the field of orthopedics, magnesium (Mg) and magnesium-based composites as biodegradable materials have attracted fundamental research. However, the medical applications of magnesium implants have been restricted owing to their poor corrosion resistance, especially in the physiological environment. To improve the corrosion resistance of Mg/HA/TiO 2 nanocomposites, monolayer MgO and double-layer Si/MgO coatings were fabricated layer-by-layer on the surface of a nanocomposite using a powder metallurgy route. Then, coating thickness, surface morphology, and chemical composition were determined, and the corrosion behavior of the uncoated and coated samples was evaluated. Field-emission scanning electron microscopy (FE-SEM) micrographs show that an inner MgO layer with a porous microstructure and thickness of around 34 µm is generated on the Mg/HA/TiO 2 nanocomposite substrate, and that the outer Si layer thickness is obtained at around 23 µm for the double-layered coated sample. Electrochemical corrosion tests and immersion corrosion tests were carried out on the uncoated and coated samples and the Si/MgO-coated nanocomposite showed significantly improved corrosion resistance compared with uncoated Mg/HA/TiO 2 in simulated body fluid (SBF). Corrosion products comprising Mg(OH) 2 , HA, Ca 3 (PO 4 ) 2 , and amorphous CaP components were precipitated on the immersed samples. Improved cytocompatibility was observed with coating as the cell viability ranged from 73% in uncoated to 88% for Si/MgO-coated Mg/HA/TiO 2 nanocomposite after nine days of incubation.

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In vitro and in vivo corrosion and histocompatibility of pure Mg and a Mg-6Zn alloy as urinary implants in rat model

Cited by 60 publications

References 40 publications

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

The Corrosion Performance and Mechanical Properties of Mg-Zn Based Alloys—A Review

Characterization of Powder Metallurgy Processed Pure Magnesium Materials for Biomedical Applications

Biodegradable Mg/HA/TiO2 Nanocomposites Coated with MgO and Si/MgO for Orthopedic Applications: A Study on the Corrosion, Surface Characterization, and Biocompatability

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