Abstract:An ability to modulate three distinct yet inter-related immune processes is required for successful allogeneic hematopoietic stem cell transplantation (HSCT): reduction in graft-versus-host reactivity that initiates graft-versus-hostdisease (GVHD), inhibition of host-versus-graft reactivity that causes allograft rejection, and enhancement of graftversus-leukemia (GVL) and graft-versus-tumor (GVT) effects that primarily account for the curative capacity of allogeneic HSCT. Each of these inter-related processes … Show more
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