In Vitro and In Vivo Evidence towards Fibronectin’s Protective Effects against Prion Infection
M. Carmen Garza,
Sang-Gyun Kang,
Chiye Kim
et al.
Abstract:A distinctive signature of the prion diseases is the accumulation of the pathogenic isoform of the prion protein, PrPSc, in the central nervous system of prion-affected humans and animals. PrPSc is also found in peripheral tissues, raising concerns about the potential transmission of pathogenic prions through human food supplies and posing a significant risk to public health. Although muscle tissues are considered to contain levels of low prion infectivity, it has been shown that myotubes in culture efficientl… Show more
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