In vitro and in vivo toxicological evaluation of extract and fractions from Baccharis trimera with anti-inflammatory activity

Nogueira, Natália Pereira de Almeida; Reis, Patrícia Alves; Laranja, G.A.T.; Pinto, Augusto Eduardo Miranda; Aiub, Cláudia Alessandra Fortes; Felzenszwalb, Israel; Paes, Márcia Cristina; Bastos, Frederico F.; Bastos, V. L. F. Cunha; Sabino, K.C.C.; Coelho, Marsen Garcia Pinto

doi:10.1016/j.jep.2011.09.051

Cited by 34 publications

(18 citation statements)

References 52 publications

(55 reference statements)

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“…Thus, suggesting the absence of toxicity of different doses of HEBT administered orally (50-5000 mg kg −1 ) or intraperitoneally (1000 mg kg −1 ), and indicating the safety of HEBT, even at high doses. Our data corroborate those from Dias et al (2009) andNogueira et al (2011), who did not find alteration in mice after 2 weeks of a single 5000 mg kg −1 dose of B. trimera, p.o., and 4.20 or 42.00 mg kg −1 of B. trimera isolated compounds. The last authors observed toxic effects of B. trimera compounds only on kidneys cells in vitro.…”

Section: Discussionsupporting

confidence: 92%

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Lívero

Silva

Maria-Ferreira

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

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Ethanol is a psychoactive substance highly consumed around the world whose health problems include gastric lesions. Baccharis trimera is used in folk medicine for the treatment of gastrointestinal disorders. However, few studies have evaluated its biological and toxic effects. To validate the popular use of B. trimera and elucidate its possible antiulcerogenic and cytotoxic mechanisms, a hydroethanolic extract of B. trimera (HEBT) was evaluated in models of gastric lesions. Rats and mice were used to evaluate the protective and antiulcerogenic effects of HEBT on gastric lesions induced by ethanol, acetic acid, and chronic ethanol consumption. The effects of HEBT were also evaluated in a pylorus ligature model and on gastrointestinal motility. The LD50 of HEBT in mice was additionally estimated. HEBT was analyzed by nuclear magnetic resonance, and a high-performance liquid chromatography fingerprint analysis was performed. Oral HEBT administration significantly reduced the lesion area and the oxidative stress induced by acute and chronic ethanol consumption. However, HEBT did not protect against gastric wall mucus depletion and did not alter gastric secretory volume, pH, or total acidity in the pylorus ligature model. Histologically, HEBT accelerated the healing of chronic gastric ulcers in rats, reflected by contractions of the ulcer base. Flavonoids and caffeoylquinic acids were detected in HEBT, which likely contributed to the therapeutic efficacy of HEBT, preventing or reversing ethanol- and acetic acid-induced ulcers, respectively. HEBT antiulcerogenic activity may be partially attributable to the inhibition of free radical generation and subsequent prevention of lipid peroxidation. Our results indicate that HEBT has both gastroprotective and curative activity in animal models, with no toxicity.

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Section: Discussionsupporting

confidence: 92%

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Lívero

Silva

Maria-Ferreira

et al. 2016

Naunyn-Schmiedeberg's Arch Pharmacol

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“…Nogueira et al . () studied Baccharis trimera , a popular plant in Brazil, and they did not observe mutagenicity, inhibition of hepatic enzymes or induction of toxic effects in kidney cells both in vivo and in vitro . However, De Alda et al .…”

Section: Discussionmentioning

confidence: 98%

Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model

Toledo

Sakoda

Perini

et al. 2013

British J Pharmacology

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BACKGROUND AND PURPOSEAsthma is an inflammatory disease that involves airway hyperresponsiveness and remodelling. Flavonoids have been associated to anti-inflammatory and antioxidant activities and may represent a potential therapeutic treatment of asthma. Our aim was to evaluate the effects of the sakuranetin treatment in several aspects of experimental asthma model in mice. EXPERIMENTAL APPROACHMale BALB/c mice received ovalbumin (i.p.) on days 0 and 14, and were challenged with aerolized ovalbumin 1% on days 24, 26 and 28. Ovalbumin-sensitized animals received vehicle (saline and dimethyl sulfoxide, DMSO), sakuranetin (20 mg kg -1 per mice) or dexamethasone (5 mg kg -1 per mice) daily beginning from 24th to 29th day. Control group received saline inhalation and nasal drop vehicle. On day 29, we determined the airway hyperresponsiveness, inflammation and remodelling as well as specific IgE antibody. RANTES, IL-5, IL-4, Eotaxin, IL-10, TNF-a, IFN-g and GMC-SF content in lung homogenate was performed by Bioplex assay, and 8-isoprostane and NF-kB activations were visualized in inflammatory cells by immunohistochemistry. KEY RESULTSWe have demonstrated that sakuranetin treatment attenuated airway hyperresponsiveness, inflammation and remodelling; and these effects could be attributed to Th2 pro-inflammatory cytokines and oxidative stress reduction as well as control of NF-kB activation. CONCLUSIONS AND IMPLICATIONSThese results highlighted the importance of counteracting oxidative stress by flavonoids in this asthma model and suggest sakuranetin as a potential candidate for studies of treatment of asthma. Abbreviations

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“…Nogueira et al [35] also identified the anti-inflammatory activity of Baccharis trimera through the reduction of paw edema induced by carrageenan, when using aqueous extract and aqueous and ethanolic fractions, in which all presented significant results. The chemical composition of the species is mostly flavonoids but also includes tannins, saponins, alkaloids, and isoprenoids.…”

Section: Arctium Lappamentioning

confidence: 99%

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

Lopes

Oliveira²,

Viçosa³

et al. 2020

Planta Med

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Compositae is the largest family of flowering plants, with more than 1600 genera and 22 000 species. It has many economic uses in foods, cosmetics, and pharmaceutics. The literature reports its numerous medicinal benefits and recognized anti-inflammatory activity. Thus, this study evaluated the technological trends of anti-inflammatory activity of Compositae, based on the survey of scientific databases, articles, and patents, as well as the website of the Brazilian National Health Regulatory Agency (ANVISA), which is responsible for registering and controlling of healthcare and cosmetic products in the Brazil. The survey was conducted between 2008 and 2018, in the databases Science Direct, Lilacs, PubMed, and Web of Science (main collection), as well as the SciELO Citation Index. The patent survey was carried out on the basis of the Derwent Innovations Index, an important source for worldwide patent consultation, which covers 20 y of registered patents. Despite the numerous studies involving species of the Compositae family in different models of anti-inflammatory activity, there are few records of patents or products on the market from these species for that purpose. Some species have a traditional use and are present even in the Phytotherapic Summary of the Brazilian Pharmacopeia. This review confirms the therapeutic potential of Compositae for the development of anti-inflammatory drugs and reinforces the need to develop competencies and reduce technological bottlenecks to promote research and innovation in biodiversity products.

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In vitro and in vivo toxicological evaluation of extract and fractions from Baccharis trimera with anti-inflammatory activity

Cited by 34 publications

References 52 publications

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Hydroethanolic extract of Baccharis trimera promotes gastroprotection and healing of acute and chronic gastric ulcers induced by ethanol and acetic acid

Flavonone treatment reverses airway inflammation and remodelling in an asthma murine model

Anti-Inflammatory Activity of the Compositae Family and Its Therapeutic Potential

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