Abstract:ABSTRACT. Intraocular pressure (IOP) evaluated by applanation tonometry via TONO-PEN XL (TP), and rebound tonometry via TonoVet (TV) were compared in enucleated canine eyes with varied pressure of the anterior chamber (AC) and in clinical cases. TV measured IOP values were lower than IOP measurements of TP in the enucleated eyes with 5-10 mmHg of AC (P<0.0001), though there was no significant difference in IOP values obtained with TP and TV on the pressure ranges of 15-20 mmHg. However, TP detected IOP values … Show more
“…13 IOP readings in adult dogs, obtained using the same type of rebound tonometer as applied in the current study, ranged between 9.16 AE 3.47 mmHg and 14.2 AE 4.5 mmHg. [22][23][24] In the present study, the initial IOP of 5.6 AE 2.7 mmHg at 2 weeks of age was below or within the lowest reported reference range for IOP in adult dogs. IOP increased significantly to 12.6 AE 1.8 mmHg at 6 weeks of age, which is well within the reported reference ranges for adult dogs.…”
Section: Discussioncontrasting
confidence: 49%
“…The youngest dogs in which IOP was described were 6 weeks of age, and IOP at that age did not differ significantly from IOP one year later . IOP readings in adult dogs, obtained using the same type of rebound tonometer as applied in the current study, ranged between 9.16 ± 3.47 mmHg and 14.2 ± 4.5 mmHg . In the present study, the initial IOP of 5.6 ± 2.7 mmHg at 2 weeks of age was below or within the lowest reported reference range for IOP in adult dogs.…”
STT1, STT2, and IOP values increased significantly in the first weeks after birth. The results of this study indicate that separate reference values for tear production and intraocular pressure need to be established for neonatal dogs.
“…13 IOP readings in adult dogs, obtained using the same type of rebound tonometer as applied in the current study, ranged between 9.16 AE 3.47 mmHg and 14.2 AE 4.5 mmHg. [22][23][24] In the present study, the initial IOP of 5.6 AE 2.7 mmHg at 2 weeks of age was below or within the lowest reported reference range for IOP in adult dogs. IOP increased significantly to 12.6 AE 1.8 mmHg at 6 weeks of age, which is well within the reported reference ranges for adult dogs.…”
Section: Discussioncontrasting
confidence: 49%
“…The youngest dogs in which IOP was described were 6 weeks of age, and IOP at that age did not differ significantly from IOP one year later . IOP readings in adult dogs, obtained using the same type of rebound tonometer as applied in the current study, ranged between 9.16 ± 3.47 mmHg and 14.2 ± 4.5 mmHg . In the present study, the initial IOP of 5.6 ± 2.7 mmHg at 2 weeks of age was below or within the lowest reported reference range for IOP in adult dogs.…”
STT1, STT2, and IOP values increased significantly in the first weeks after birth. The results of this study indicate that separate reference values for tear production and intraocular pressure need to be established for neonatal dogs.
“…Rebound tonometry has shown a strong linear relationship when compared with results obtained with manometry in enucleated dog eyes (Knollinger et al 2005 ). A separate study using manometry reported that rebound tonometry was reliable in hypertensive eyes (Nagata et al 2011 ). Rebound tonometry gives higher readings than applanation tonometry in dogs with acute glaucoma and an IOP that is >25 mmHg (Slack et al 2012 ).…”
Summary:Objectives:To establish an intraocular pressure curve protocol that is safe for corneal health and determining if they detect harmful elevations of intraocular pressure outside normal clinic hours. To determine inter-user variability and if repeated measurements affect intraocular pressures.Methods: Dogs with glaucoma were included in the first part of the study in which intraocular pressures were measured using three protocols. Protocol 1 used applanation tonometry every two hours over 24h. Protocols 2 and 3 used applanation or rebound tonometry, respectively, and measured intraocular pressures every three hours over 30h. Sixty additional intraocular pressure curves from dogs with glaucoma and 20 from healthy dogs were then analysed for inter-user variability.
Results:128 Intraocular pressure curves were determined in 30 dogs. Protocol 1 resulted in one ulcer in five pressure curve measurements, Protocol 2 in one ulcer in 62 pressure curves, and Protocol 3 in no ulcers in 61. Elevated intraocular pressures were detected on 61 occasions, of which 26 developed outside normal clinic hours. Sixty-one additional intraocular pressure curves revealed that repeated measurements had no effect on intraocular pressure. Assessors had a significant variability in righteye but not left-eye readings.Conclusions: Protocol 3, using rebound tonometry every three hours for 30hr is safe and identified elevated intraocular pressures outside normal clinic hours in 12/30 (40%) of patients that single intraocular pressure measurement during consultation hours would not have identified. Intraocular pressure curves may be recommended for clinical practice and glaucoma studies.
“…[ 35 ] Previous studies have shown that the Tono-Pen readings were not significantly different from the Tonovet readings for normotensive eyes. [ 36 , 37 ] Since all IOPs in our previous study were within the range of 10–18 mmHg, these IOP data were combined in the analyses without further conversion. Tonometry was performed on most of the dogs throughout their lifespans ( Table 1 ).…”
Soft tissue often displays marked age-associated stiffening. This study aims to investigate how age affects scleral biomechanical properties in a canine glaucoma model with ADAMTS10 mutation, whose extracellular matrix is concomitantly influenced by the mutation and an increased mechanical load from an early age. Biomechanical data was acquired from ADAMTS10-mutant dogs (n = 10, 21 to 131 months) and normal dogs (n = 5, 69 to 113 months). Infusion testing was first performed in the whole globes to measure ocular rigidity. After infusion experiments, the corneas were immediately trephined to prepare scleral shells that were mounted on a pressurization chamber to measure strains in the posterior sclera using an inflation testing protocol. Dynamic viscoelastic mechanical testing was then performed on dissected posterior scleral strips and the data were combined with those reported earlier by our group from the same animal model (Palko et al, IOVS 2013). The association between age and scleral biomechanical properties was evaluated using multivariate linear regression. The relationships between scleral properties and the mean and last measured intraocular pressure (IOP) were also evaluated. Our results showed that age was positively associated with complex modulus (p<0.001) and negatively associated with loss tangent (p<0.001) in both the affected and the normal groups, suggesting an increased stiffness and decreased mechanical damping with age. The regression slopes were not different between the groups, although the complex modulus was significantly lower in the affected group (p = 0.041). The posterior circumferential tangential strain was negatively correlated with complex modulus (R = -0.744, p = 0.006) showing consistent mechanical evaluation between the testing methods. Normalized ocular rigidity was negatively correlated with the last IOP in the affected group (p = 0.003). Despite a mutation that affects the extracellular matrix and a chronic IOP elevation in the affected dogs, age-associated scleral stiffening and loss of mechanical damping were still prominent and had a similar rate of change as in the normal dogs.
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