In vitro and in vivo biocompatibility and corrosion behaviour of a bioabsorbable magnesium alloy coated with octacalcium phosphate and hydroxyapatite

Hiromoto, Sachiko; Inoue, Motoki; Taguchi, Tetsushi; Yamane, Masayuki; Ohtsu, Naofumi

doi:10.1016/j.actbio.2014.09.026

Cited by 186 publications

(119 citation statements)

References 45 publications

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“…The majority of this research into Mg biocorrosion has been conducted via in vitro immersion tests [27][28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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The factors that influence magnesium (Mg) corrosion in vitro are systematically evaluated from a review of the relevant literature. We analysed the influence of the following factors on Mg biocorrosion in vitro: (i) inorganic ions, including both anions and cations, (ii) organic components such as proteins, amino acids and vitamins, and (iii) experimental parameters such as temperature, pH, buffer system and flow rate. Considerations and recommendations towards a standardised approach to in vitro biocorrosion testing are given. Several potential simulated body fluids are recommended. Implementing a standardised approach to experimental parameters has the potential to significantly reduce variability between in vitro biocorrosion tests, and to help build towards a methodology that accurately and consistently mimics in vivo corrosion. However, there are also knowledge gaps with regard to how best to characterise the in vivo environment and corrosion mechanism. The assumption that blood plasma is the correct bodily fluid upon which to base in vitro methodologies is examined, and factors that influence the corrosion mechanism in vivo, such as specimen encapsulation, bear consideration for further studies.

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“…The majority of this research into Mg biocorrosion has been conducted via in vitro immersion tests [27][28][29][30][31][32][33][34][35][36][37][38][39].…”

Section: Medical Magnesium and Biocorrosionmentioning

confidence: 99%

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

2017

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“…We developed a simple chemical solution deposition method for coating hydroxyapatite (HAp) and octacalcium phosphate (OCP) on Mg/Mg alloys [12][13][14][15][16][17][18]. HAp and OCP coatings retarded corrosion of Mg alloy substrate in vitro and in vivo, and reduced inflammation in the subcutaneous tissue of mice [19]. The HAp coating showed good adhesiveness to the Mg alloy substrate under static tensile deformation with 5% elongation and under fatigue loading accompanying 3% cyclic elongation [18].…”

Section: Introductionmentioning

confidence: 98%

“…Magnesium and its alloys are suitable for use as orthopaedic implant materials because they are bioabsorbable/biodegradable and therefore do not require surgical removal. They also have high specific strength and low Young's modulus (41)(42)(43)(44)(45) GPa) similar to that of bone (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) [1][2][3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Self-healing property of hydroxyapatite and octacalcium phosphate coatings on pure magnesium and magnesium alloy

Hiromoto

2015

Corrosion Science

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“…Among them, hydroxyapatite (HA) has similar chemical and crystallographic structures with the inorganic components of bone in vivo (25-50 nm in length and 2-5 nm thick) (Olsztaa et al, 2007). Synthetic nanosized HA has excellent biocompatibility and osteo-conductivity (Zhou & Lee, 2011;Fox et al, 2012), and tunable control ability on size, morphology, and assembly (Zhou & Lee, 2011), which make them important candidates for bone regeneration and the delivery of growth factors (Alghamdi et al, 2014;Tan et al, 2014;Hiromoto et al, 2015). Therefore, much attention has recently been paid on biological studies of effects of HA nanoparticles on cell behaviors.…”

Section: Hydroxyapatite Nanoparticlesmentioning

confidence: 99%

Biological responses to nanomaterials: understanding nano-bio effects on cell behaviors

Liu

Tang

2017

Drug Delivery

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The unique properties of nanomaterials in drug delivery and tissue engineering have captured a great deal of attention as experimental tools in bioimaging, diagnostic, and therapeutic processes. A plenty of research have provided a strong evidence that nanostructures not only passively interact with cells but also actively engage and mediate cell functions and molecular processes. Undoubtedly, it is crucially important to better understand biological responses to engineered nanomaterials, especially in view of their potential for biomedical applications. In this review, we shall highlight recent advances in exploring nano-bio effects in diverse systems of nanoparticles, nanotopographies, and mixed composite scaffolds. We will also discuss their manipulating functions on cellular behaviors and important biological processes of adhesion, morphology, proliferation, migration, differentiation, and even hidden mechanisms including molecular signaling pathways. At last, the perspectives will be addressed for further directions of nanomaterial designs with the purpose of better drug delivery and cell therapies. ARTICLE HISTORY

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In vitro and in vivo biocompatibility and corrosion behaviour of a bioabsorbable magnesium alloy coated with octacalcium phosphate and hydroxyapatite

Cited by 186 publications

References 45 publications

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Building towards a standardised approach to biocorrosion studies: a review of factors influencing Mg corrosion in vitro pertinent to in vivo corrosion

Self-healing property of hydroxyapatite and octacalcium phosphate coatings on pure magnesium and magnesium alloy

Biological responses to nanomaterials: understanding nano-bio effects on cell behaviors

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