In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

Adamcová, Michaela; Šimůnek, Tomáš; Kaiserová, Helena; Popelová, Olga; Štěrba, Martin; Potáčová, Anna; Vávrová, Jaroslava; Maláková, Jana; Geršl, Vladimír

doi:10.1016/j.tox.2007.05.016

Cited by 55 publications

(45 citation statements)

References 49 publications

(48 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…it could be transformed into a linear relationship in the semilogarithmic plot. Similarly, other authors reported the exponential relationship between cardiomyocyte viability and cTnT level 15 . A more complicated relationship (power function) was found between myocardial calcium content and cTnT level.…”

Section: Biomarkers Of the Cardiovascular Injurymentioning

confidence: 62%

“…They are used successfully in the diagnosis of AMI with better sensitivity over previously used biomarkers. Various studies have described excellent negative correlations of cTnT concentration with the left ventricular contractility impairment or cardiomyocyte viability and positive one with myocardial infarction size 15,16 . In our previous study, we established a correlation of the cTnT concentration with cardiac function parameters in a relatively small number of animals 10 .…”

Section: Biomarkers Of the Cardiovascular Injurymentioning

confidence: 99%

See 1 more Smart Citation

Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats

Mladěnka¹,

Zatloukalová²,

Filipský³

et al. 2013

BIOMED PAP

View full text Add to dashboard Cite

Background. Predicting cardiovascular events remains challenging despite the range of known biomarkers. Aim. To establish relationships between various biochemical and functional parameters of the cardiovascular system. Method. The relationship between cardiovascular dys/function and various biomarkers was examined in 145 experimental rats half of which received isoprenaline 100 mg/kg s.c. to induce cardiac impairment. Results. Serum concentration of cardiac troponin T (cTnT), a known marker of cardiac derangement, correlated strongly with degree of myocardial injury (e.g. calcium overload, stroke volume) but correlations between cTnT and oxidative stress parameters were weak (for glutathione and vitamin C) or not found (for serum vitamin E and plasma thiobarbituric acid reactive substances levels). Relationships between cTnT and other parameters were exponential with the exception of myocardial calcium, where a power function was found. Conclusions. Commonly used biomarkers of oxidative stress cannot reliably predict cardiovascular dys/function in experimental rats.

show abstract

Section: Biomarkers Of the Cardiovascular Injurymentioning

confidence: 62%

Section: Biomarkers Of the Cardiovascular Injurymentioning

confidence: 99%

Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats

Mladěnka¹,

Zatloukalová²,

Filipský³

et al. 2013

BIOMED PAP

View full text Add to dashboard Cite

show abstract

“…However, as noted with the younger animals, samples from fetal animals had considerably higher cTnI concentrations did samples from adults. Because Li et al (2004), Adamcová et al (2007), and and Hessel, Michielsen, et al (2008) used different versions of the cTnI assay, it is not possible to determine whether the amount of serum added to the culture media had any effect on the ultimate cTnI concentrations The present study demonstrated that cTnI concentrations are not uniform at all ages. An important observation was that high levels of cTnI appear in the serum early in life.…”

Section: Cardiac Pathologymentioning

confidence: 70%

The Influence of Age on Serum Concentrations of Cardiac Troponin I

et al. 2013

View full text Add to dashboard Cite

Cardiac troponins serve as serum biomarkers of myocardial injury. The current study examined the influence of age on serum concentrations of cardiac troponin I (cTnI). An ultrasensitive immunoassay was used to monitor cTnI concentrations in Sprague-Dawley (SD) rats and Erythrocebus patas monkeys of different ages. The mean cTnI concentrations were highest in 10-day-old rats compared to 25-, 40-, and 80-day-old SD rats. Cardiomyocyte remodeling was apparent in hearts from 10-day-old SD rats as evident by hypercellularity, irregularly shaped nuclei, and moderate numbers of myocytes undergoing mitosis and apoptosis. The mean concentration of cTnI in 5 newborn monkeys was considerably higher than that of three 1-year-old monkeys. Evidence of cardiomyocyte remodeling was also observed in these newborn hearts (loss of myofibrils and cytoplasmic vacuolation). Commercial animal serum samples were also analyzed. The concentrations of cTnI detected in fetal equine and porcine serum were considerably higher than that found in adult equine and porcine serum samples Likewise, fetal bovine serum had higher cTnI concentrations (>2,400 pg/ml) than did adult caprine and laprine samples (2.5-2.7 pg/ml). The present study found age-related differences in cTnI concentrations, with higher levels occurring at younger ages. This effect was consistent across several animal species.

show abstract

“…Many studies have also elucidated that troponin value can remain elevated for a period ranging from a few hours to several months, after the completion of CT. (19,20,21,28,30) On the other hand, the exact time-point at which a negative troponin value reaches 100% of specificity for no further troponin release cannot yet be defined, (31) therefore, repeated blood samples are required to pick out a possible troponin increase. This represents a possible limitation for using these markers in clinical practice.…”

Section: Troponinsmentioning

confidence: 99%

Using biomarkers and early prophylactic treatment to prevent cardiotoxicity in cancer patients on chemotherapy

Bacchiani

Cardinale

2017

SAHJ

View full text Add to dashboard Cite

Using biomarkers and early prophylactic treatment to prevent cardiotoxicity in cancer patients on chemotherapy goal for both cardiologists and oncologists. The main strategy to prevent clinical cardiotoxicity is early detection and the initiation of prompt prophylactic therapy. EARLY DETECTION OF CARDIOTOXICITY Current approachPeriodic assessment for LVEF is the most widely used non-invasive method for detecting cardiotoxicity LVEF either via echocardiography or multigated acquisition scanning. Although several available guidelines exist none specify how often, by what means or how long cardiac function should be monitored during and after cancer treatment. The recommendations of these guidelines are not consistent and seem to be based on modest evidence. Though LVEF is a crude index of cardiac function, it is relatively insensitive in detecting anticancer drug-induced cardiotoxicity at an early stage. Usually there are compensatory mechanisms in place to ensure normal overall function in a patient despite an initial reduction in myocardial contractility. As a rule no considerable

show abstract

In vitro and in vivo examination of cardiac troponins as biochemical markers of drug-induced cardiotoxicity

Cited by 55 publications

References 49 publications

Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats

Common biomarkers of oxidative stress do not reflect cardiovascular dys/function in rats

The Influence of Age on Serum Concentrations of Cardiac Troponin I

Using biomarkers and early prophylactic treatment to prevent cardiotoxicity in cancer patients on chemotherapy

Contact Info

Product

Resources

About