In vitro and in vivo biodegradation and biocompatibility of an MMT/BSA composite coating upon magnesium alloy AZ31

Wang, Jian; Cui, Lan-Yue; Ren, Yande; Zou, Yuhong; Ma, Jinlong; Wang, Chengjian; Zhou, Zheng; Chen, Xiaobo; Zeng, Rong‐Chang; Zheng, Yufeng

doi:10.1016/j.jmst.2020.02.006

Cited by 60 publications

(15 citation statements)

References 64 publications

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“…In the present study, we formulated NIC with bovine serum albumin (BSA) and the resulting nanoparticles (NPs) were coated physically with PEG. The major reason for selecting BSA was due to its immense bio-compatibility[ 20 , 21 ] and stabilizing capability [ 22 ]. Various biomedical applications including drug delivery [ [23] , [24] , [25] , [26] , [27] , [28] , [29] ], tissue engineering [ [30] , [31] , [32] , [33] ] and bio imaging, etc.…”

Section: Introductionmentioning

confidence: 99%

Injectable niclosamide nanohybrid as an anti-SARS-CoV-2 strategy

Rejinold

Piao

Jin³

et al. 2021

Colloids and Surfaces B: Biointerfaces

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Section: Introductionmentioning

confidence: 99%

Injectable niclosamide nanohybrid as an anti-SARS-CoV-2 strategy

Rejinold

Piao

Jin³

et al. 2021

Colloids and Surfaces B: Biointerfaces

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“…The process of ML depends on the interaction between magnesium and the hydroxide ions in the fluid, per Equation (12). It is a very common method of establishing corrosion when performing in vitro tests [15,[63][64][65]67,[71][72][73][74][75][76][77]. ML is then measured in units of mass per exposed surface area, see Equation (24).…”

Section: Unpolarized Tests Mass Lossmentioning

confidence: 99%

“…Hydrogen evolution is another method to measure the degradation rate that was used by several research groups [63,64,66,74,76,77]. The degradation of magnesium inside aqueous solutions was found to result in hydrogen gas evolution according to Equation (12).…”

Section: Hydrogen Evolution Measurementmentioning

confidence: 99%

Corrosion Modeling of Magnesium and Its Alloys for Biomedical Applications: Review

Abdalla

Joplin

Elahinia

et al. 2020

CMD

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Biodegradable metals have been under significant research as promising alternatives to the currently in-use nonbiodegradable materials in the field of supportive medical implants. In this scope, magnesium and its alloys were widely investigated due to their superior biocompatibility over other metals. Most of the research effort in the literature has been focused on assuring the biocompatibility, improving mechanical properties, and tailoring the corrosion rate of magnesium-based implants. Furthermore, considerable research was done to develop numerical models towards an inexpensive and fast designing tools capable of simulating the degradation/corrosion behavior of magnesium-based implants. Due to the complexity of the degradation process and the various factors that can be involved, several hypotheses were introduced to provide a realistic simulation of the corrosion behavior in vitro and in vivo. A review of the current literature hypothesis and different modeling constitutive equations for modeling the corrosion of magnesium alloys along with a summary of the supplementary experimental methods is provided in this paper.

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“…Furthermore, the coated implant led to a mild to moderate fibrosis with less bone destruction, while the bare implant led to scar formation. Wang et al (2019) prepared a montmorillonite/bovine serum albumin (MMT-BSA) coating on the AZ31 alloy and the in vivo results indicated that the coated implant was capable of maintaining its structural integrity within 120 days and no toxic side effects were observed. Sun et al (2016) investigated the in vivo effects of a fluorine coated Mg alloy implanted into a rabbit mandibular and femur and the results suggested a lower degradation rate and an improved osteogenic activity as compared to the bare alloy.…”

Section: Biological and Biomedical Sciencesmentioning

confidence: 99%

In vitro and in vivo biological performance of Mg-based bone implants

Negrescu¹,

Necula²,

Costache³

et al. 2020

Rev. Biol. Biomed. Sci.

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With the rapid advancement of medical technology, it is crucial that a considerable body of biomaterials are taken into consideration and tested for the purpose of bone implant fabrication. Over the last decades degradable metallic materials have attracted increasing interest in the field of hard tissue engineering due to their ability to degrade once they have fulfilled their function, without causing side effects that could potentially be harmful for the human body. In this context, Mg-based biomaterials gained special attention due to their bone-like mechanical properties, good biocompatibility and osteoconductive properties. However, their use in biomedical applications is limited due to their rapid corrosion in physiological environments. Therefore, it is important to reduce the degradation process of these biomaterials for safe biomedical applications. Two main strategies that could potentially lead to a lower corrosion rate are represented by alloying and surface treatment. This review provides a summary of the recent specialized literature concerning Mg-based biomaterials with a special focus on the recent in vitro and in vivo studies regarding Mg-based bone implants.

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In vitro and in vivo biodegradation and biocompatibility of an MMT/BSA composite coating upon magnesium alloy AZ31

Cited by 60 publications

References 64 publications

Injectable niclosamide nanohybrid as an anti-SARS-CoV-2 strategy

Injectable niclosamide nanohybrid as an anti-SARS-CoV-2 strategy

Corrosion Modeling of Magnesium and Its Alloys for Biomedical Applications: Review

In vitro and in vivo biological performance of Mg-based bone implants

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