In vitro and in vivo studies reveal the beneficial effects of chlorogenic acid against ER stress mediated ER-phagy and associated apoptosis in the heart of diabetic rat

R, Preetha Rani M; P, Salin Raj; Nair, Anupama; Sreedharan, Ranjith; Rajankutty, K; G, Raghu K.

doi:10.1016/j.cbi.2021.109755

Cited by 14 publications

(8 citation statements)

References 39 publications

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“…The addition of CA reduced the expression of GRP78, CHOP, and caspase-12, as well as the expression of Sec62 and RTN3, which stimulates ER autophagy. The mechanism is related to the reduction of ER stress-mediated autophagy by CA-regulated IRE1α, ATF6α, and PERK/eIF2α ( Preetha Rani et al, 2022 ). Besides CA, Astragalus polysaccharides, ginsenoside Rg1, and matrine also mitigate DCM by inhibiting ER stress ( Yu et al, 2016 ; Hou et al, 2019 ; Sun et al, 2019 ).…”

Section: Natural Products For Regulating Diabetic Microvascular Compl...mentioning

confidence: 99%

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

Liu,

Zhao,

et al. 2024

Front. Pharmacol.

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As the quality of life improves, the incidence of diabetes mellitus and its microvascular complications (DMC) continues to increase, posing a threat to people’s health and wellbeing. Given the limitations of existing treatment, there is an urgent need for novel approaches to prevent and treat DMC. Autophagy, a pivotal mechanism governing metabolic regulation in organisms, facilitates the removal of dysfunctional proteins and organelles, thereby sustaining cellular homeostasis and energy generation. Anomalous states in pancreatic β-cells, podocytes, Müller cells, cardiomyocytes, and Schwann cells in DMC are closely linked to autophagic dysregulation. Natural products have the property of being multi-targeted and can affect autophagy and hence DMC progression in terms of nutrient perception, oxidative stress, endoplasmic reticulum stress, inflammation, and apoptosis. This review consolidates recent advancements in understanding DMC pathogenesis via autophagy and proposes novel perspectives on treating DMC by either stimulating or inhibiting autophagy using natural products.

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Section: Natural Products For Regulating Diabetic Microvascular Compl...mentioning

confidence: 99%

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

Liu,

Zhao,

et al. 2024

Front. Pharmacol.

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“… Myocardial fibrosis; Apoptosis. [ [159] , [160] , [161] ] Alkaloid Tetramethylpyrazine Ligusticum chuanxiong microRNA-499a, Sirtuin1; PI3K/Akt pathway. Oxidative stress; Apoptosis.…”

Section: The Representative Natural Products With Anti-heart Failure ...mentioning

confidence: 99%

The recent advance and prospect of natural source compounds for the treatment of heart failure

Chen,

Liu,

et al. 2024

Heliyon

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“…A variety of factors including hyperglycemia, AGEs accumulation, oxidative stress, and ischemia, cause the accumulation of unfolded proteins, and trigger unfolded protein response, which ultimately leads to myocardial apoptosis and hypertrophy (Fernández et al, 2015; He et al, 2018). Glucose‐regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) as markers of ERS play an important role in DCM (Preetha Rani et al, 2022). Moreover, ERS can induce autophagy, and autophagy protects ERS‐mediated apoptosis by negative feedback.…”

Section: Introductionmentioning

confidence: 99%

“…Glucose-regulated protein 78 (GRP78) and C/EBP homologous protein (CHOP) as markers of ERS play an important role in DCM (Preetha Rani et al, 2022). Moreover, ERS can induce autophagy, and autophagy protects ERS-mediated apoptosis by negative feedback.…”

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confidence: 99%

D‐pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin‐mediated endoplasmic reticulum stress and glycophagy signaling pathway

Li,

Yu,

et al. 2024

Phytotherapy Research

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Diabetic cardiomyopathy (DCM) is an important complication resulting in heart failure and death of diabetic patients. However, there is no effective drug for treatments. This study investigated the effect of D‐pinitol (DP) on cardiac injury using diabetic mice and glycosylation injury of cardiomyocytes and its molecular mechanisms. We established the streptozotocin‐induced SAMR1 and SAMP8 mice and DP (150 mg/kg/day) intragastrically and advanced glycation end‐products (AGEs)‐induced H9C2 cells. H9C2 cells were transfected with optineurin (OPTN) siRNA and overexpression plasmids. The metabolic disorder indices, cardiac dysfunction, histopathology, immunofluorescence, western blot, and immunoprecipitation were investigated. Our results showed that DP reduced the blood glucose and AGEs, and increased the expression of heart OPTN in diabetic mice and H9C2 cells, thereby inhibiting the endoplasmic reticulum stress (GRP78, CHOP) and glycophagy (STBD1, GABARAPL1), and alleviating the myocardial apoptosis and fibrosis of DCM. The expression of filamin A as an interaction protein of OPTN downregulated by AGEs decreased OPTN abundance. Moreover, OPTN siRNA increased the expression of GRP78, CHOP, STBD1, and GABARAPL1 and inhibited the expression of GAA via GSK3β phosphorylation and FoxO1. DP may be helpful to treat the onset of DCM. Targeting OPTN with DP could be translated into clinical application in the fighting against DCM.

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In vitro and in vivo studies reveal the beneficial effects of chlorogenic acid against ER stress mediated ER-phagy and associated apoptosis in the heart of diabetic rat

Cited by 14 publications

References 39 publications

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

Targeting autophagy with natural products as a potential therapeutic approach for diabetic microangiopathy

The recent advance and prospect of natural source compounds for the treatment of heart failure

D‐pinitol alleviates diabetic cardiomyopathy by inhibiting the optineurin‐mediated endoplasmic reticulum stress and glycophagy signaling pathway

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