In vitro and in vivo anti-leukemia activity of the stem bark of Salacia impressifolia (Miers) A. C. Smith (Celastraceae)

Cyperus articulatus L. (Cyperaceae) Rhizome Essential Oil Causes Cell Cycle Arrest in the G2/M Phase and Cell Death in HepG2 Cells and Inhibits the Development of Tumors in a Xenograft Model

“…In our cytotoxic screening program, extract/EO samples with an IC 50 value below 30 µg/mL against cancer cell lines are selected for further studies [24][25][26][27][28]. C. articulatus rhizome EO showed an IC 50 value of 28.5 µg/mL against liver cancer HepG2 cells, presenting moderate potency when compared to doxorubicin that showed an IC 50 value of 0.03 µg/mL and 5-fluorouracil with an IC 50 value of 0.2 µg/mL for this cell line.…”

Structural Requirements for Antimicrobial Activity of Phenolic Nor-Triterpenes from Celastraceae Species

“…The natural phenolic nor-triterpenes 1 (6-oxopristimerol) [20,26], 3 (7,8-dihydro-6-oxoiguesterol, canarol) [27], 16 (6-oxotingenol) [20], 17 (3-O-methyl-6-oxotingenol) [20], and 20 (6-oxoiguesterol) [20] were isolated from the root bark of Maytenus canariensis, and compounds 2 (7-hydroxy-6oxopristimerol) [21,28], 4 (blepharodol) [21], 5 (7α-hydroxyblepharodol) [27], 10 (blepharotriol) [21], 12 (zeylasteral) [27,29], 13 (demethylzeylasteral) [21,29], 14 (zeylaterone) [27,29], 15 As part of an intensive investigation into antimicrobial metabolites from Celastraceae species, we report herein on the minimal inhibitory concentrations (MICs) of five natural phenolic nor-triterpenes (1)(2)(3)(4)(5) and four derivatives (6-9), three of them reported for the first time, against Gram-positive and Gram-negative bacteria, and the yeast Candida albicans. The structure-activity relationship study of compounds 1-9 was expanded by the known antimicrobial activity of a series of phenolic nor-triterpenes (10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26), previously reported by our research group…”

“…To understand the structural basis for the antimicrobial activity of this type of compounds, we have performed an in-depth study of the structure-activity relationship (SAR) of a series of previously reported phenolic nor-triterpenes. The SAR analysis was based on the skeleton framework, oxidation degree, functional groups, and regiosubstitution patterns, revealing that these aspects modulate the antimicrobial activity.products shows a wide range of bioactivities, including cytotoxic [10,11], anti-inflammatory [12], antioxidant [13], antiparasitic [14], and insecticidal [15] properties. Concerning their antimicrobial activity, pristimerin, tingenone, celastrol, and netzahualcoyone ( Figure 1) exhibit inhibitory activity against Gram-positive bacteria [8,16,17], and the mode of action of netzahualcoyone against Bacillus subtilis and Escherichia coli has been investigated [18,19].…”

“…products shows a wide range of bioactivities, including cytotoxic [10,11], anti-inflammatory [12], antioxidant [13], antiparasitic [14], and insecticidal [15] properties. Concerning their antimicrobial activity, pristimerin, tingenone, celastrol, and netzahualcoyone ( Figure 1) exhibit inhibitory activity against Gram-positive bacteria [8,16,17], and the mode of action of netzahualcoyone against Bacillus subtilis and Escherichia coli has been investigated [18,19].…”

Chemodiversity of Essential Oils from Nine Species of Celastraceae

“…It is estimated that this family comprises a total of 1350 species belonging to 96 different genera . Many Celastraceae species present pharmacological activities such as antitumor, anti‐inflammatory, antimicrobial, antioxidant, antiviral, analgesic, and acetylcholinesterase inhibitor …”