In vitro and in vivo antioxidant activity of a fructan from the roots of Arctium lappa L.

Liu, Wei; Wang, Jiajia; Zhang, Zhenzhen; Xu, Jingliang; Xie, Zhuohong; Slavin, Margaret; Gao, Xiangdong

doi:10.1016/j.ijbiomac.2014.01.062

Cited by 85 publications

(54 citation statements)

References 25 publications

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“…After that, percent of inulin begins to decrease gradually and reached 7.3% at the last time point. Compared with previous reports (Frese, Dambroth, & Bramm, 1991;Liu et al, 2014;Yang et al, 2010), the yield of inulin extracted from Jerusalem artichoke was greater than or equal to the yield in other species (i.e., chicory, burdock, Morinda officinalis). This indicates that Jerusalem artichoke could be a resource to produce inulin in China.…”

Section: Discussioncontrasting

confidence: 86%

Extraction, degree of polymerization determination and prebiotic effect evaluation of inulin from Jerusalem artichoke

Zhang

Chen

et al. 2015

Carbohydrate Polymers

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: Degree of polymerization of inulin GFC Jerusalem artichoke Prebiotic effect a b s t r a c tThe tubers of Jerusalem artichoke are rich of inulin, which makes the plant one of primary inulin resources in China. The aim of this study was to extract inulin from tubers and test the degree of polymerization (DP) 10 days before flowering to 80 days after flowering. The DP of inulin reaches a maximum of 19 at 50 days after flowering. The variation tendencies of inulin content and DP were almost the same, which increase rapidly at the beginning and then decrease gradually at a lower speed. Meanwhile, the effects of inulin on probiotics in yogurt have been evaluated. It indicated that inulin with low DP has higher activities. Experimental data improve the understanding of status change of inulin in whole growth of Jerusalem artichoke tubers in Northeastern China and are instructive to get inulin with different properties.

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Section: Discussioncontrasting

confidence: 86%

Extraction, degree of polymerization determination and prebiotic effect evaluation of inulin from Jerusalem artichoke

Zhang

Chen

et al. 2015

Carbohydrate Polymers

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“…Some authors evaluated the antioxidant capacity of A. lappa extracts obtained with hot‐water extractions (Jimenez‐Zamora, Delgado‐Andrade & Rufian‐Henares, ; Li et al, ; Liu et al, ). Particularly, whole plant extract antioxidant activity was 207.71 ± 19.86 μmol Fe (II) per g (FRAP) and 167.89 ± 18.78 μmol TE per g (ABTS; Li et al, ).…”

Section: The Role Of a Lappa In Contrasting The Oxidative Stressmentioning

confidence: 99%

“…On the other hand, antioxidant assays were performed on water infusion, and following results, expressed as mmol TE per l, were found: 1.00 ± 0.00 for ABTS, 1.26 ± 0.02 for DPPH and 1.00 ± 0.11 for FRAP (Jimenez‐Zamora, Delgado‐Andrade & Rufian‐Henares, ). Interestingly, Liu et al () conducted a study using a water extract, in order to evaluate the antioxidant activity of polysaccharides from A. lappa root. At first, the researchers evaluated this activity with in vitro assays, including hydroxyl radical scavenging assay, ABTS, and chelating ability on ferrous ions, finding a strong activity, particularly 99.19% (at 2.5 mg/ml, compared with ascorbic acid), 72.5% (at 5.0 mg/ml, compared with Trolox), and nearly 100% (at 1.25–5.0 mg/ml, compared with EDTA).…”

Section: The Role Of a Lappa In Contrasting The Oxidative Stressmentioning

confidence: 99%

“…The activity of endogenous defences against ROS, including superoxide dismutase (SOD), glutathione peroxidase (GSH‐Px), catalase (CAT), the levels of malondialdehyde (MDA; a marker of peroxidation), and total antioxidant capacity (TAOC) were evaluated. The authors found significant increases in SOD, GSH‐Px, CAT, and TAOC and decreased levels of MDA (Liu et al, ). Similar results were found in further in vitro studies conducted on two different cell lines (Tian et al, ; Wang et al, ).…”

Section: The Role Of a Lappa In Contrasting The Oxidative Stressmentioning

confidence: 99%

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Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal‐based studies

Annunziata

Barrea²,

Ciampaglia

et al. 2019

Phytotherapy Research

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Diabetes is a metabolic disease highly widespread worldwide, and the most common form is the type 2 diabetes mellitus (T2DM). A large number of synthetic drugs are currently available for the treatment of diabetes; however, they present various side effects and, for this reason, people are increasingly inclined to search natural alternative treatments. Among these, Arctium lappa (A. lappa) has interesting anti‐diabetic activities, exerted by improving glucose homeostasis and reducing insulin‐resistance. In addition, A. lappa exerts a marked antioxidant activity, an effect known to play a pivotal role in the treatment of T2DM. The purpose of this review is to analyse scientific evidence in order to evaluate the role of A. lappa and its bioactive compounds in management of T2DM. The literature search performed provided only in vitro and animal‐based studies. No clinical studies have been conducted in order to investigate the effect of A. lappa on T2DM patients. However, available literature provides evidence for further clinical trials in order to confirm these claimed activities on humans.

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“…A. lappa has demonstrated potent antioxidant effects in vitro and in vivo (Duh, 1998;Liu et al, 2014) and protective effects in an acute experimental colitis model (De Almeida et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots

Conea

Mogoşan

Voștinaru

et al. 2017

Not Bot Horti Agrobo

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The aim of the study was to assess the polyphenolic profile, anti-inflammatory and antinociceptive activity of Arctium lappa, a medicinal plant traditionally used in the treatment of gout, hepatitis and other inflammatory disorders. Polyphenolic profile of a hydro-glycero-ethanolic extract from Arctium lappa roots (ALE) was evaluated by HPLC-MS method. Antiinflammatory effect of the Arctium lappa extract (ALE) was determined by carrageenan-induced rat paw oedema test, while antinociceptive effect was determined by acetic acid induced writhing test in mice and Randall Selitto test in rats. HPLC-MS analysis of the extract showed the presence of chlorogenic acid (158.9 μg/mL) and quercitrin (14.4 μg/mL). The administration of ALE reduced the oedema formation in the carrageenan-induced rat paw oedema test, especially at dose of 500 mg/kg, the results being statistically significant and dose-dependent. Also, ALE showed statistically significant and dosedependent antinociceptive effects in the acetic acid induced writhing test in mice and Randall Selitto test in rats. The results of the pharmacological experiments suggest that the anti-inflammatory and antinociceptive effects of the Arctium lappa extract (ALE) may be related to the ability of polyphenols such as chlorogenic acid to inhibit the synthesis and release of some proinflammatory mediators. Our experimental data justify the traditional use of this plant in the management of some inflammatory diseases.

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In vitro and in vivo antioxidant activity of a fructan from the roots of Arctium lappa L.

Cited by 85 publications

References 25 publications

Extraction, degree of polymerization determination and prebiotic effect evaluation of inulin from Jerusalem artichoke

Extraction, degree of polymerization determination and prebiotic effect evaluation of inulin from Jerusalem artichoke

Arctium lappa contributes to the management of type 2 diabetes mellitus by regulating glucose homeostasis and improving oxidative stress: A critical review of in vitro and in vivo animal‐based studies

Polyphenolic Profile, Anti-Inflammatory and Antinociceptive Activity of an Extract from Arctium lappa L. Roots

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