In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization

Marinho, Juliane Aparecida; Guimarães, Daniel Silqueira Martins; Glanzmann, Nícolas; Pimentel, Giovana de Almeida; Nunes, Izabelle Karine da Costa; Pereira, Henrique Marcelo Gualberto; Navarro, Maribel; Varotti, Fernando de Pilla; Silva, Adilson David da; Abramo, Clarice

doi:10.1016/j.ejmech.2021.113271

Cited by 19 publications

(6 citation statements)

References 40 publications

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“…N-(7-chloroquinolin-4-yl)-ethanediamine (6) reacts with various aromatic aldehydes in the presence of ethanol as a solvent to form different imine quinoline derivatives(6a-b). Both the compounds are excellent antimalarial inhibitors and it was described by Juliane Aparecida Marinho et al [9] ECS Transactions, 107 (1) 17523-17533 (2022)…”

Section: Imine Quinoline Derivativementioning

confidence: 99%

A Mini-Review On The Current Scenario Of Quinoline Scaffolds For Antimalarial Activity

Ilakiyalakshmi¹,

Arumugam²

2022

ECS Trans.

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Antimalarial agents are an important key for the prevention and eradication of malaria. The heterocyclic aromatic quinoline scaffold is a favored structure in drug development because its derivatives have a wide range of biological properties. The quinoline family contains a lot of antimalarial agents like chloroquine, piperaquine, quinine, etc. Chloroquine had been a significant antimalarial agent for more than five decades. To enhance the efficacy in malarial treatment a new system of several other quinoline-based drugs has been synthesized. This mini-review intends to provide a literature overview of antimalarial compounds containing a quinoline core, encompassing papers from 2018 to the present along with the synthesis and pertinent figures. It could be useful for researchers to design more effective antimalarial drugs in the future.

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Section: Imine Quinoline Derivativementioning

confidence: 99%

A Mini-Review On The Current Scenario Of Quinoline Scaffolds For Antimalarial Activity

Ilakiyalakshmi¹,

Arumugam²

2022

ECS Trans.

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“…As a result, compound 57 presents itself as a good candidate for further development into a novel anti-malarial agent. [83] Dassonville et al developed, synthesised and tested aminoalcohol quinolines (58) against Pf3D7 (IC 50 of 14.9 nM and SI of 778) and PfW2 (IC 50 of 11.0 nM and SI of 3174) strains through in vitro assay. Additionally, 58 showed no clastogenic, mutagenic, or aneugenic properties.…”

Section: Quinolinementioning

confidence: 99%

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

Dhameliya,

Patel,

Kathuria

et al. 2024

ChemistrySelect

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Malaria remains a severe infectious disease caused by Plasmodium parasites among the primarily afflicting impoverished populations. According to World Health Organization (WHO) report, there were an estimated 247 million malarial cases globally, resulting in approximately 6,19,000 fatalities. Particularly prevalent in tropical and subtropical regions, the development of drug resistance has exacerbated this public health challenge. Consequently, there has been a concrete effort to explore novel compounds with anti‐malarial properties. In continuation of our previous works, this review focuses on heterocyclic compounds documented in 2021 and 2022, including artemisinin, benzimidazole, benzofuran, β‐lactam, coumarin, furan, indole, morpholine, piperazine, pyrimidine, quinoline, triazole, etc. highlighting their efficacy, structural characteristics, in vitro and in vivo activities, among other relevant aspects for the broad interest of medicinal chemists working on the design and development of novel anti‐malarial agents.

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“…49 Indeed, there are several examples in which the quinoline core has been associated with the inhibition of β-hematin crystallization through performing in vitro and in vivo experiments. [50][51][52][53][54][55][56] Chloroquine (CQ) is the most successful of the quinoline-based compounds, favoured due to its low cost and high efficacy, and has served as the model for other quinoline antimalarial agents, such as mefloquine and amodiaquine. However, resistance to CQ and its derivatives has led to a decline in their popularity and efficacy.…”

Section: Rsc Medicinal Chemistry Reviewmentioning

confidence: 99%

Is structural hybridization invoking new dimensions for antimalarial drug discovery research?

2023

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In vitro and in vivo antiplasmodial activity of novel quinoline derivative compounds by molecular hybridization

Cited by 19 publications

References 40 publications

A Mini-Review On The Current Scenario Of Quinoline Scaffolds For Antimalarial Activity

A Mini-Review On The Current Scenario Of Quinoline Scaffolds For Antimalarial Activity

Biannual Account of Anti‐malarial Agents reported in 2021 and 2022: A Comprehensive Coverage

Is structural hybridization invoking new dimensions for antimalarial drug discovery research?

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