In-Vitro and in-Vivo Anti-Inflammatory Activities of<i>Salvia hispanica</i>and<i>Linum usitatissium</i>Seeds in Swiss Albino Rats

Vidyasabbani,; Alli, Ramesh; Snehalatha,; Rahul, B. Parmar; Sriharitha,; Sanjayvarma,; Aparna,

doi:10.5958/0974-360x.2015.00258.9

Cited by 3 publications

(2 citation statements)

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“…Research Institute for Pharmaceutical Education, Narsapur, Medak, Telangana, India (2015) conducted a study to assess in vitro anti-inflammatory activity of flax. Ethanolic extract showed its maximum effectiveness in dissolving calcium oxalate crystals, thereby clearly showing that ethanolic extract of flaxseed was quite promising for further research on the treatment of kidney stones [36].…”

Section: Pharmacological Effects and Usesmentioning

confidence: 93%

Impact of Vitamins and Minerals Enriched Flora in the Management of Calciphytoliths: A Special Focus on Vitamin E

Govindan¹,

Tilak²,

Sivaramakumar³

et al. 2021

Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects

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Calciphytoliths (calcium oxalate calculi) have a great influence on human health and are a disease with a high likelihood of recurrence at a rate of more than 10% within a year. Plant flavonoids, saponins, and tannins are reported to be Litholytic by inhibiting calcium oxalate crystals or by their calcium channel blocking activity. Vitamins and minerals containing flora completely prevent deposition of oxalate by preventing pre-oxidation injury and restoring renal tissue antioxidants. So vitamin therapy also might protect against oxalate calculi deposition in the human kidneys. The present chapter discusses the impact of vitamins especially vitamin E, calcium, and low oxalate-containing plants for the management of various urinary or kidney disorders.

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Section: Pharmacological Effects and Usesmentioning

confidence: 93%

Impact of Vitamins and Minerals Enriched Flora in the Management of Calciphytoliths: A Special Focus on Vitamin E

Govindan¹,

Tilak²,

Sivaramakumar³

et al. 2021

Vitamin E in Health and Disease - Interactions, Diseases and Health Aspects

View full text Add to dashboard Cite

show abstract

“…There are about 700 -900 species that are distributed in temperate and warm areas of both hemispheres. BAS of sage species have a potential application as anti-inflammatory, antiseptic, immunomodulating, hypoglycemic, antidiabetic, antioxidant, hepatoprotective, wound healing agents, as well as have the ability to prevent neurovegetative diseases and stimulate antitumor activity [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Antibacterial Activity of Salvia stepposa Extracts Isolated using Microwave Extraction, Growing Wild in Kazakhstan

et al. 2022

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The studies on antibacterial activity of 16 samples of Salvia stepposa (steppe sage) ethanolic extracts, an indigenous plant of Central Kazakhstan, against Staphylococcus aureus (ATCC 6538), Bacillus subtilis (ATCC 6633), Escherichia coli (ATCC 25922), Candida albicans (ATCC 10231) were assayed. Leaves and flowers of Salvia stepposa were extracted by ethanol 30, 40, 70 and 90 % using conventional and microwave extraction. Antibacterial screening performed by disc-diffusion method was conducted, the concentration of all extracts was 100 mg/mL. The results revealed that the highest activity against Staphylococcus aureus and Bacillus subtilis have leaves and flowers extract of steppe sage in all solvents except 70 % microwave leaf extract. The only extract that showed antibacterial activity against all strains of microorganisms used is 40 % microwave leaf extract of steppe sage with growth inhibition zones for Staphylococcus aureus 23.5 0.65 mm, for Bacillus subtilis 38 1.3 mm, for Escherichia coli 16.5 1.72 mm, for Candida albicans 16 2.6 mm, respectively. Was found that 70 % of leaf extract of the steppe sage obtained under microwave irradiation has the lowest activity. The MIC values for tested extracts were evaluated too. HIGHLIGHTS Salvia stepposa is a widespread plant on the territory of Kazakhstan the properties of which still remain unexplored Antibacterial activity and MIC of 16 examples obtained different methods was evaluated MAE is an interesting alternative to CE of extracting plant raw materials, which can reduce extraction time and energy consumption

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Bis-Mannich Base derivatives of Curcumin Pyrazole: Synthesis and its Anti-inflammatory Study In-vitro and In-Silico

D. Aryati,

Z. Tifani,

K. Putri

et al. 2024

RJPT

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A series of bis-Mannich base derivatives of curcumin pyrazole (CP) have been synthesized and investigated for the potential of its anti-inflammatory activity in-vitro and in-silico. The synthesis was performed by aminomethylation of CP obtained from the cyclization of the 1,3-diketone chain of curcumin with hydrazine hydrate. The potential as an anti-inflammatory was accessed by the protein denaturation inhibition technique, and an in-silico study was performed against cyclooxygenase-1 and cyclooxygenase-2 via molecular docking. All the compounds showed better protein denaturation inhibitory activity than diclofenac sodium, curcumin, and CP used as standard and comparable compounds. Compound 2a exhibited the best active compound. The docking study found that the binding energy to COX-2 of all the compounds was lower than that of COX-1. The selectivity score (S) indicated that the compounds were very selective against COX-2. So, all the compounds possess high potential as anti-inflammatory agents, and further study is necessary to identify these compounds' safety and activity in- vivo.

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In-Vitro and in-Vivo Anti-Inflammatory Activities ofSalvia hispanicaandLinum usitatissiumSeeds in Swiss Albino Rats

Cited by 3 publications

References 0 publications

Impact of Vitamins and Minerals Enriched Flora in the Management of Calciphytoliths: A Special Focus on Vitamin E

Impact of Vitamins and Minerals Enriched Flora in the Management of Calciphytoliths: A Special Focus on Vitamin E

Evaluation of Antibacterial Activity of Salvia stepposa Extracts Isolated using Microwave Extraction, Growing Wild in Kazakhstan

Bis-Mannich Base derivatives of Curcumin Pyrazole: Synthesis and its Anti-inflammatory Study In-vitro and In-Silico

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