Abstract:Tolterodine (TOL) is an antimuscarinic drug used for
the treatment
of patients with overactive bladder presenting urinary frequency,
urgency, and urge incontinence. During the clinical use of TOL, adverse
events such as liver injury took place. The present study aimed at
the investigation of the metabolic activation of TOL possibly associated
with its hepatotoxicity. One GSH conjugate, two NAC conjugates, and
two cysteine conjugates were found in both mouse and human liver microsomal
incubations supplemented w… Show more
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