In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers

Giblin, Michael F.; Sieckman, Gary L.; Shelton, Tiffani; Hoffman, Timothy J.; Forte, Leonard R.; Volkert, Wynn A.

doi:10.1016/j.nucmedbio.2006.01.009

Cited by 20 publications

(19 citation statements)

References 35 publications

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“…For example, MAbs 8 , CPPs 10 , Affibody molecules 11 , albumin 12 , BsAbs 13 , transferrin 14 and stable toxin peptides 15 are some of the new classes of transmembrane delivery vectors with high pharmaceutical potential.…”

Section: Issn: 0975-8232mentioning

confidence: 99%

“…Some of those peptides that have promising potential in targeting anticancer drugs and imaging agents are briefly discussed as follows; 15 .…”

Section: Peptides As Anticancer Drug Targeting Carriersmentioning

confidence: 99%

“…In addition, different other analogs of STh are currently being used as vectors to target human colon cancers 15,92 . For example, STh that is genetically fused to another heterologous protein still retains its native biological properties such as secretion, enterotoxicity, folding, GCC recognition and which is poorly antigenic, or almost nonimmunogenic has been established a highly attractive tool as a cell targeting and delivering vector, not only for small therapeutic molecules like radionuclides, but also for large proteinaceous anticancer agents 93 .…”

Section: Peptides As Anticancer Drug Targeting Carriersmentioning

confidence: 99%

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2013

IJPSR

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Section: Issn: 0975-8232mentioning

confidence: 99%

“…Some of those peptides that have promising potential in targeting anticancer drugs and imaging agents are briefly discussed as follows; 15 .…”

Section: Peptides As Anticancer Drug Targeting Carriersmentioning

confidence: 99%

Section: Peptides As Anticancer Drug Targeting Carriersmentioning

confidence: 99%

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2013

IJPSR

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“…Orally administered Ugn suppressed the development of tumors in multiple intestinal neoplasia (Min) mice and much speculation has since centered on the use of GC-C agonists in anticancer hormone replacement therapy [71]. GC-C binding peptides that have been tagged with radionuclides have also been suggested as a highly specific, targeted approach to cancer radiotherapy but low-level expression of GC-C in extraintestinal tissue remains possible and therefore a concern [77,78].…”

Section: Intestinal Transmembrane Guanylate Cyclase Receptors: Intestmentioning

confidence: 99%

Transmembrane guanylate cyclase in intestinal pathophysiology

Steinbrecher

Cohen

2011

Current Opinion in Gastroenterology

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Progress toward understanding gastrointestinal transmembrane guanylate cyclase/cGMP physiology has recently accelerated due to definitive in-vitro studies and work using gene-targeted animal models and has facilitated the development of safe and effective drugs designed to regulate cGMP production in the intestine. Current work should be directed toward a detailed understanding of cGMP effector pathways and the manner in which subcellular concentrations of cGMP regulate them to influence intestinal health and disease.

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“…This receptor is present in high density on the apical surface of normal intestinal epithelial cells as well as on the surface of human colon cancer cells. At present, STh analogues are used to target radionuclides to human colon cancers (27). …”

Section: Introductionmentioning

confidence: 99%

Peptide‐mediated cancer targeting of nanoconjugates

Raha

Paunesku

Woloschak

2010

WIREs Nanomed Nanobiotechnol

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Targeted use of nanoparticles in vitro, in cells and in vivo requires nanoparticle surface functionalization. Moieties that can be used for such a purpose include small molecules as well as polymers made of different biological and organic materials. Short amino acid polymers--peptides can often rival target binding avidity of much larger molecules. At the same time, peptides are smaller than most nanoparticles and thus allow for multiple nanoparticle modifications and creation of pluripotent nanoparticles. Most nanoparticles provide multiple binding sites for different cargo and targeting peptides which can be used for development of novel approaches for cancer targeting, diagnostics and therapy. In this review, we will focus on peptides which have been used for preparation of different nanoparticles designed for cancer research.

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In vitro and in vivo evaluation of 177Lu- and 90Y-labeled E. coli heat-stable enterotoxin for specific targeting of uroguanylin receptors on human colon cancers

Cited by 20 publications

References 35 publications

Untitled

Untitled

Transmembrane guanylate cyclase in intestinal pathophysiology

Peptide‐mediated cancer targeting of nanoconjugates

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