In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production

Shen, Shing Chuan; Lee, William R.; Lin, Hui Yi; Huang, H. C.; Ko, Ching Huai; Yang, Lingling; Chen, Yen Chou

doi:10.1016/s0014-2999(02)01792-2

Cited by 210 publications

(125 citation statements)

References 37 publications

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“…Prostaglandins and nitric oxide biosynthesis are involved in inflammation, and isoforms of inducible nitric oxide synthase (iNOS) and of cyclooxygenase (COX-2) are responsible for the production of a great amount of inflammatory mediators. It has also been demonstrated that flavonoids are able to inhibit both enzymes (Marcinkiewicz, 1997;Chen et al, 2001;Shen et al, 2002). Flavonoids modulate the cascade of molecular events leading to the over-expression of these mediators which include inhibition of the transcription factors such as nuclear factor-κB (NFκB) and activating protein-1 (AP-1), through the inhibition of protein kinases involved in signal transduction (González-Gallego et al, 2007;Tuñón et al, 2009).…”

Section: Figure 2 Effect Of Afe On Lps-induced Tnfα Production In VImentioning

confidence: 99%

Extracts ofFicus exasperataleaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expression of mediators of inflammation in macrophages

Nworu

Nwuke

Akah

et al. 2012

Journal of Immunotoxicology

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Section: Figure 2 Effect Of Afe On Lps-induced Tnfα Production In VImentioning

confidence: 99%

Extracts ofFicus exasperataleaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expression of mediators of inflammation in macrophages

Nworu

Nwuke

Akah

et al. 2012

Journal of Immunotoxicology

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“…Thus far, studies have indicated that flavanols [72,105], flavones [34,87,99,151,186], and flavonols [35] are all capable of inhibiting the release of NO…”

Section: Extracellular Signal-regulated Protein Kinase Pathwaymentioning

confidence: 99%

The interactions of flavonoids within neuronal signalling pathways

2007

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Emerging evidence suggests that dietary phytochemicals, in particular flavonoids, may exert beneficial effects in the central nervous system by protecting neurons against stress-induced injury, by suppressing neuroinflammation and by promoting neurocognitive performance, through changes in synaptic plasticity. It is likely that flavonoids exert such effects in neurons, through selective actions on different components within a number of protein kinase and lipid kinase signalling cascades, such as phosphatidylinositol-3 kinase (PI3K)/Akt, protein kinase C and mitogen-activated protein kinase. This review details the potential inhibitory or stimulatory actions of flavonoids within these pathways, and describes how such interactions are likely to affect cellular function through changes in the activation state of target molecules and/or by modulating gene expression. Although, precise sites of action are presently unknown, their abilities to: (1) bind to ATP binding sites on enzymes and receptors; (2) modulate the activity of kinases directly; (3) affect the function of important phosphatases; (4) preserve neuronal Ca 2+ homeostasis; and (5) modulate signalling cascades lying downstream of kinases, are explored. Future research directions are outlined in relation to their precise site(s) of action within the signalling pathways and the sequence of events that allow them to regulate neuronal function in the central nervous system.

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“…Wogonin, 5,7-dihydroxy-8-methoxyflavone, originating from the root of Scutellaria baicalensis Georgi, has been used as a traditional phytochemical for inflammationrelated diseases (7). This flavonoid has been shown to exert antiinflammatory effects via selective inhibition of both COX-2 (7) and inducible nitric oxide synthase (iNOS) in macrophages (7,8) or induction of apoptosis via activation of caspase-3 in HL-60 cells (9). However, the effects of wogonin in gastric physiology or pathophysiology in an in vivo system have not been reported.…”

mentioning

confidence: 99%

Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats

Park

Hahm

et al. 2004

Dig Dis Sci

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Whether wogonin (5,7-dihydroxy-8-methoxyflavone), a flavonoid originated from the root of Scutellaria baicalensis Georgi, which has been shown to have antiinflammatory and antitumor activities in various cell types, possesses a gastric cytoprotective effect was investigated in an ethanol-induced gastric damage model in rats. Ethanol administration alone induced evident gastric damage including gastric hemorrhages and edema, while this gastric damage was significantly attenuated by wogonin pretreatment (30 mg/kg B.W.) 1 hr before ethanol administration. As major protective mechanisms of wogonin on ethanol-induced gastric damage, we found that wogonin showed either antiinflammatory effects through dual actions on arachidonic acid metabolism, i.e., induction of prostaglandin D 2 and suppression of 5S-hydroxyeicosatetraenoic acid (5S-HETE), or preventive induction of profuse apoptosis in the stomach. Conclusively, the flavonoid wogonin could be used as a preventive agent of alcohol-induced gastropathy, whose actions were proven to be strong antiinflammation and apoptosis induction.

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In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E2 production

Cited by 210 publications

References 37 publications

Extracts ofFicus exasperataleaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expression of mediators of inflammation in macrophages

Extracts ofFicus exasperataleaf inhibit topical and systemic inflammation in rodents and suppress LPS-induced expression of mediators of inflammation in macrophages

The interactions of flavonoids within neuronal signalling pathways

Preventive Effect of the Flavonoid, Wogonin, Against Ethanol-Induced Gastric Mucosal Damage in Rats

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