In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense

Ramazani, Ali; Zakeri, Sedigheh; Sardari, Soroush; Khodakarim, Nastaran; Djadidt, Navid Dinparas

doi:10.1186/1475-2875-9-124

Cited by 74 publications

(47 citation statements)

References 22 publications

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“…This activity could be related to the plant alkaloids contents (Janot et al, 1959;Yemoa et al, 2015). According to Saxena et al (2003) and Ramazani et al (2010) several classes of secondary metabolites are responsible for the antimalarial activity, but the most important and diverse potential bioactivity has been observed with alkaloids. Alkaloids are one of the major antimalarial natural products and various classes have been reported to exhibit promising activities.…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Potentials of Ethanolic Extract of Leaves of Holarrhena Floribunda (G. Don) Dur. And Schinz (Apocynaceae)

Hoekou¹,

Tchacondo²,

Karou³

et al. 2017

Afr J Tradit Complement Altern Med

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Background: Holarrhena floribunda is a plant of wide usage in the Togolese folk medicine. A previous ethnobotanical survey on the latex plants of the Maritime region of the country revealed that this plant was included in several recipes curing malaria and microbial infections. Therefore, this study aimed to seek for the effectiveness of the ethanolic extract of the plant in the treatment of these diseases. Methods: The antimicrobial test was performed using the agar well-diffusion and the NCCLS broth microdilution methods, while the in vivo antimalarial activity was evaluated following the four-day suppressive test of Peters. The acute toxic effects of the extract were monitored after a single oral dose (5,000 mg/kg body weight) administration in NMRI mice. Results:The results indicated that the ethanolic extract of leaves of H. floribunda was active on Staphylococcus aureus ATCC 29213 and clinical strains of Staphylococcus aureus, Salmonella typhi and Klebsiella pneumoniae with MICs ranging from 0.62 to 1.25 mg/mL. The extract also showed significant parasitaemia suppression in a dose-dependent manner. In the acute toxicity assay, the oral administration of the extract to the mice did not affect the relative weight of vital organs, and there were no signs of toxicity or death during the study period. The LD 50 of the tested extract was found to be greater than 5,000 mg/kg, indicating its safety. Conclusion: This study demonstrates the antibacterial and antimalarial activities of leaves of H. floribunda and then, supports its medicinal use in the treatment of microbial infections.Key words: Holarrhena floribunda, ethanolic extract, antibacterial, antimalarial, toxicity. IntroductionHolarrhena floribunda (G. Don) T. Durand and Schinz, is a plant belonging to the family of Apocynaceae. It grows as a shrub or a tree. The plant is widely distributed in West Africa, where several parts of the plant are used for medicinal purposes (Yemoa et al., 2015). The stem-bark and leaves are used to treat various diseases including malaria, fever, dysentery, amoebic diseases, diarrhoea, sterility, amenorrhea and diabetes (Bouquet & Debray, 1974;Kerharo & Adam, 1974;Arbonnier, 2000;Fotie et al., 2006;Bayala et al., 2006). The roots are boiled in milk and used to bathe boys attaining puberty in addition to cure snakebites and venereal diseases (Iwu, 2014). In our previous study on the latex plant used in the maritime region of Togo, we found that the decoction of the plant was administrated by oral route for the treatment of malaria and bacterial infections (Hoekou et al., 2016).Some previous pharmacological screenings showed that, the stem bark of H. floribunda was febrifuge and could be a quinine substitute, since it showed remarkable inhibitory activity against drug-resistant strains of Plasmodium falciparum. The chemical screening of the plant revealed the presence of steroid alkaloids notably conessine, that is used for the destruction of amoeba without emetic effects (Berhaut, 1971;Fotie et al., 2006). The antioxida...

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Section: Discussionmentioning

confidence: 99%

Therapeutic Potentials of Ethanolic Extract of Leaves of Holarrhena Floribunda (G. Don) Dur. And Schinz (Apocynaceae)

Hoekou¹,

Tchacondo²,

Karou³

et al. 2017

Afr J Tradit Complement Altern Med

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“…The present determination of antimalarial effect of the S. griseus extract is additional proof of its medicinal values, and it can, thus, be assumed that the extract can be safe at the dose levels used in the study [27]. According to Saxena et al [27] and Ramazan et al [28], several classes of secondary metabolites are responsible for the antimalarial activity, the antimalarial activities exhibited by this extract may also be due to the presence of other active compounds.…”

Section: Sweetline and Ushamentioning

confidence: 63%

Evaluation of the Antimalarial Potential of Streptomyces Sp.

Sweetline

Usha

2018

Asian J Pharm Clin Res

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Objective: Isolate, screen and identify Streptomyces sp. from mangrove soil from pichavaram, Tamil Nadu, India, and study the molecular identification of selected Streptomyces sp. and check the antimalarial activity for the purified compound.Methods: The16SrRNA secondary structure and the restriction sites of KMA08 were predicted using Genbank online software, respectively. Antiplasmodial activity of the 80% Ethyl acetate extract of Streptomyces sp. against chloroquine-sensitive Plasmodium berghei in mice using the 4 days suppression test was conducted. A total of 30 mice assigned to 5 groups of 6 animals each were infected with chloroquine-sensitive (P. berghei) intraperitoneally. The Ethyl acetate extract (10, 20, and 30 ml/kg), standard drug (chloroquine, 10 mg/kg) and distilled water were administered orally daily for the treatment period. Percent Parasitemia was determined on the 5 th day from Giemsa stained smears obtained from tail vein and percent parasitemia suppression was calculated. Daily measurement of rectal temperature was also taken while body weight and packed cell volume were recorded on day 0 and 5. Results:Results showed the extract produced a dose-dependent reduction in parasite density compared to the control group. Percept parasitemia calculation revealed 21.3, 65.3, and 80.5% inhibition at 10, 20, and 30 ml/kg of the extract, respectively. Conclusion:The study revealed the present work indicated that Streptomyces sp. has as promising antiplasmodial activity against chloroquine sensitive P. berghei in a dose-dependent. As part of the drug discovery process, these promising finding may contribute to the medicinal and pharmaceutical field for malarial treatment.

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“…Boerhavia elegans (Choisy) showed promising anti-plasmodial activity in vitro (IC50<or = 50 microgram/ml) and in vivo with no toxicity [51].…”

Section: Antimalarial Activitymentioning

confidence: 99%

An Update Review on Ethnomedicinal, Phytochemical and Pharmacological Profile of genus Boerhavia

Aslam¹

2017

IJCAM

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The genus Boerhavia (Nyctaginaceae) consists of 40 species that are distributed in humid, subtropical and warm climate regions. Traditional healers have been patronizing various species of this genus in numerous disorders since time immemorial. Some of them are already validated scientifically such as antimicrobial, antioxidant, ant diabetic, antiasthmatic, anticonvulsant, cytotoxic, antiulcer, anti-inflammatory, analgesic and Hepatoprotetcive. While much more are still needed to address. Phytochemically different groups of compounds have been isolated from various species of this genus like alkaloids, flavonoids, rotenoids and phytosterols. This review present chemical and pharmacological data from recent phytochemical studies on various plants of the genus Boerhavia.

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In vitro and in vivo anti-malarial activity of Boerhavia elegans and Solanum surattense

Cited by 74 publications

References 22 publications

Therapeutic Potentials of Ethanolic Extract of Leaves of Holarrhena Floribunda (G. Don) Dur. And Schinz (Apocynaceae)

Therapeutic Potentials of Ethanolic Extract of Leaves of Holarrhena Floribunda (G. Don) Dur. And Schinz (Apocynaceae)

Evaluation of the Antimalarial Potential of Streptomyces Sp.

An Update Review on Ethnomedicinal, Phytochemical and Pharmacological Profile of genus Boerhavia

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