In vitro and in vivo studies with new platinum complexes containing ammine, sulfide, phosphine and another groups as ligands.

Sampedro, F.; Ruiz, J.I.; Molins-Pujol, A.M.; Santaló, P.; Moranta, C.; Pueyo, M; Llagostera, Montserrat; Bonal, J.

doi:10.1016/0162-0134(91)84570-y

Cited by 3 publications

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“…In recent years, a series of additional compounds of this kind have been prepared and characterized by Longato et al [16][17][18][19][20][21] Some related phosphane platinum compounds were prepared and characterized over the last years in other research laboratories worldwide. [22][23][24][25][26][27][28][29][30] The established opinion concerning platinum phosphane complexes, mostly arising from older studies, 31 is that they are nearly devoid of antiproliferative activity. However, this feature is often due to a poor solubility of the phosphane platinum compounds and is still controversial and debated.…”

Section: Introductionmentioning

confidence: 99%

Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(ii) compounds with sulfur and phosphorus donors

et al. 2011

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Twelve Pt(II) complexes with cis-PtP(2)S(2) pharmacophores (where P(2) refers to two monodentate or one bidentate phosphane ligand and S(2) is a dithiolato ligand) were prepared, characterized and evaluated as potential antiproliferative agents. The various compounds were first studied from the structural point of view; afterward, their solubility properties as well as their solution behaviour were analyzed in detail. Antiproliferative properties were specifically evaluated against A2780 human ovarian carcinoma cells, either resistant or sensitive to cisplatin. For comparison purposes similar studies were carried out on four parent cis-dichloro bisphosphane Pt(II)complexes. On the whole, the cis-PtP(2)S(2) compounds displayed significant antiproliferative properties while the cis-PtP(2)Cl(2) (cis-dichloro bisphosphane Pt(II)) compounds revealed quite poor biological performances. To gain further insight into the molecular mechanisms of these bisphosphane Pt(II) compounds, the reactions of selected complexes against the model protein cytochrome c were investigated by ESI-MS and their adduct formation explored. A relevant reactivity with cyt c was obtained only for cis-PtP(2)Cl(2) compounds, whereas cis-PtP(2)S(2) compounds turned out to be nearly unreactive. The obtained results are interpreted and discussed in the frame of the current knowledge of anticancer platinum compounds and their structure-activity-relationships. The observation of appreciable antiproliferative effects for the relatively inert cis-PtP(2)S(2) compounds strongly suggests that these compounds will undergo specific activation within the cellular environment.

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Section: Introductionmentioning

confidence: 99%

Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(ii) compounds with sulfur and phosphorus donors

et al. 2011

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Synthesis and cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

Řezníček

Dostál

Růžička

et al. 2012

Applied Organom Chemis

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H 3 ]SbPh 2 }PtCl 2 (6) as the result of different ability of the starting compounds 1-3 to complex platinum centre. Compounds 1-6 were characterized by 1 H, 13 C and 31 P NMR spectroscopy and electrospray ionization mass spectrometry, and molecular structures of 3-6 were determined by X-ray diffraction analysis. The substitution reactions of complexes 4-6 were also studied. The reaction of 5 and 6 with NaI yielded complexes {[2,6-(Me 2 NCH 2 ) 2 C 6 H 3 ]PPh 2 }PtI 2 (7) and {[2,6-(Me 2 NCH 2 ) 2 C 6 H 3 ]SbPh 2 }PtI 2 (8), while the same reaction of 4 with NaI did not proceed. As the compounds 7 and 8 structurally resemble cisplatin, complex {{[2-(Me 2 NCH 2 )-6-(Me 2 NHCH 2 )C 6 H 3 ]PPh 2 }PtCl 2 } + Cl À (9) was prepared as water-soluble platinum complex. The cytotoxic effect of complex 9 was evaluated on human T-lymphocytic leukemia cells MOLT-4 (IC 50 = 27.6 AE 1.8 mmol l À1 ) and human promyelocytic leukemia HL-60 (IC 50 = 55.9 AE 4.9 mmol l À1 ).

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Preclinical studies with new pyrrolidine platinum(II) compounds

Sampedro

Haperen²,

Izquierdo

et al. 1995

European Journal of Medicinal Chemistry

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In vitro and in vivo studies with new platinum complexes containing ammine, sulfide, phosphine and another groups as ligands.

Cited by 3 publications

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Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(ii) compounds with sulfur and phosphorus donors

Structure, solution chemistry, antiproliferative actions and protein binding properties of non-conventional platinum(ii) compounds with sulfur and phosphorus donors

Synthesis and cytostatic activity of Pt(II) complexes of intramolecularly coordinated phosphine and stibine ligands

Preclinical studies with new pyrrolidine platinum(II) compounds

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