In vitro and in vivo studies of 5,7-dihydroxy flavones isolated from Alpinia galanga (L.) against human lung cancer and ascetic lymphoma

Lakshmi, S.; Suresh, Sandra; Bhaskar, Rahul; Saikant, R.; Maya, Vani; Gopi, Manoj; Padmaja, G.; Remani, P.

doi:10.1007/s00044-018-2260-3

Cited by 19 publications

(6 citation statements)

References 30 publications

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“…Structural features of isolated compounds were elucidated using techniques such as NMR, IR, UV, and a comparison was made between spectroscopic and physical data. These compounds were identified as 4-methyl salicylic acid 1 , Cinnamic acid 2 , Chrysin 3 , Gallic acid 4 , Apigenin 5 , and Myricetin 6 as depicted in Supplementary Table S1 [ 34 , 35 , 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

Chemical Profiling, Antioxidant, and Antimicrobial Activity of Saudi Propolis Collected by Arabian Honey Bee (Apis mellifera jemenitica) Colonies

et al. 2022

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Propolis (bee glue) is a complex, phyto-based resinous material obtained from beehives. Its chemical and biological properties vary with respect to bee species, type of plants, geographical location, and climate of a particular area. This study was planned with the aim of determining the chemical composition and to investigate various properties (against oxidants and microbes) of different extracts of Saudi propolis collected from Arabian honey bee (Apis mellifera jemenitica) colonies headed by young queens. Chemical analysis of propolis extracts with different solvents, i.e., ethyl acetate (Eac), methanol (Met), butanol (BuT), and hexane (Hex) was done through colorimetry for the total phenolic content (TPC) and total flavonoid content (TFC) evaluation. For separation and extensive characterization of the Met extract, chromatography and 1H NMR were deployed. Six different microorganisms were selected to analyze the Saudi-propolis-based extract’s antimicrobial nature by measuring zones of inhibition (ZOI) and minimum inhibitory concentration (MIC). Molecular docking was done by utilizing AutodDock, and sketching of ligands was performed through Marvin Chem Sketch (MCS), and the resultant data after 2D and 3D clean were stored in .mol format. The highest TFC (96.65 mg quercetin equivalents (QE)/g of propolis) and TPC (325 mg gallic acid equivalents (GAE)/g of propolis) were noted for Met. Six familiar compounds were isolated, and recognition was done with NMR. Met extract showed the greatest 1,1-diphenyl-2-picrylhydrazyl radical (DPPH) free radical scavenging activity and Ferric Reducing Antioxidant Power (FRAP). Met showed max microbial activity against Staphylococcus aureus (ZOI = 18.67 mm, MIC = 0.625 mg/mL), whereas the minimum was observed in Hex against E. coli (ZOI = 6.33 mm, MIC = 2.50 mg/mL). Furthermore, the molecular docking process established the biological activity of separated compounds against HCK (Hematopoietic cell kinase) and Gyrase B of S. aureus. Moreover, the stability of protein–ligand complexes was further established through molecular dynamic simulation studies, which showed that the receptor–ligand complexes were quite stable. Results of this research will pave the way for further consolidated analysis of propolis obtained from Arabian honey bees (A. m. jemenitica).

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Section: Resultsmentioning

confidence: 99%

Chemical Profiling, Antioxidant, and Antimicrobial Activity of Saudi Propolis Collected by Arabian Honey Bee (Apis mellifera jemenitica) Colonies

et al. 2022

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“…Inhibition of cell proliferation was seen in cell viability assays [37]. The increase in cell accumulation occurred in the S phase then inhibition occurred in the G1/S phase [38]. Induction of apoptosis occurs by targeting mitochondria.…”

Section: Resultsmentioning

confidence: 99%

Systematic Review: Anticancer Potential of Active Compounds from Galangal (Alpinia galanga)

Suciati¹,

Maryati²

2022

Atlantis Highlights in Chemistry and Pharmaceutical Sciences

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Galangal (Alpinia galanga) is a plant that is widely spread in Southeast Asia and is widely used for cooking spices. Research related to the effect of A. galanga on cancer cells has been carried out. The purpose of this systematic review is to examine the potential of A. galanga as an anticancer agent and co-chemotherapy. The literature search was carried out through the Pubmed, Science Direct, Springer Link, DOAJ, and Garuda Portal databases. The keywords used were "Alpinia Galanga and Anticancer", "Alpinia Galanga and Cytotoxicity", "Lengkuas dan Sitotoksik", "Lengkuas dan Kanker", and "Alpinia Galanga and Cancer". Of the 965 articles found at the beginning of the search, 31 articles were obtained which had been filtered and discussed further. The results showed that the ethanolic extract of A. galanga had a cytotoxic effect because it contained antioxidant polyphenols that inhibited cell proliferation by stopping the cell cycle. The most abundant compounds in A. galanga as anticancer agents are 1'-Acetoxychavicol Acetate (ACA) and Galangin. ACA works to inhibit cancer cells by inducing apoptosis through mitochondrial depolarization and DNA fragmentation in the cell cycle phase. Meanwhile, Galangin works as a chemopreventive agent that reduces oxidative stress and inflammation by suppressing the MAPKs pathway.

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“…Investigators also noted decreased cell proliferation following the application of chrysin. In a follow-up in vivo study, researchers treated tumor-bearing BALB/c mice with chrysin at a dose of 1.3 mg/kg and observed an increase in caspase-3-mediated apoptosis [195]. Curcumin Curcumin (Figure 5) is a spice derived from Curcuma longa L. with substantial evidence for its use as a chemotherapeutic agent.…”

Section: Chrysinmentioning

confidence: 99%

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

Choudhary

Bawari

Burcher

et al. 2023

Cancers

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Lung cancer is a heterogeneous group of malignancies with high incidence worldwide. It is the most frequently occurring cancer in men and the second most common in women. Due to its frequent diagnosis and variable response to treatment, lung cancer was reported as the top cause of cancer-related deaths worldwide in 2020. Many aberrant signaling cascades are implicated in the pathogenesis of lung cancer, including those involved in apoptosis (B cell lymphoma protein, Bcl-2-associated X protein, first apoptosis signal ligand), growth inhibition (tumor suppressor protein or gene and serine/threonine kinase 11), and growth promotion (epidermal growth factor receptor/proto-oncogenes/phosphatidylinositol-3 kinase). Accordingly, these pathways and their signaling molecules have become promising targets for chemopreventive and chemotherapeutic agents. Recent research provides compelling evidence for the use of plant-based compounds, known collectively as phytochemicals, as anticancer agents. This review discusses major contributing signaling pathways involved in the pathophysiology of lung cancer, as well as currently available treatments and prospective drug candidates. The anticancer potential of naturally occurring bioactive compounds in the context of lung cancer is also discussed, with critical analysis of their mechanistic actions presented by preclinical and clinical studies.

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In vitro and in vivo studies of 5,7-dihydroxy flavones isolated from Alpinia galanga (L.) against human lung cancer and ascetic lymphoma

Cited by 19 publications

References 30 publications

Chemical Profiling, Antioxidant, and Antimicrobial Activity of Saudi Propolis Collected by Arabian Honey Bee (Apis mellifera jemenitica) Colonies

Chemical Profiling, Antioxidant, and Antimicrobial Activity of Saudi Propolis Collected by Arabian Honey Bee (Apis mellifera jemenitica) Colonies

Systematic Review: Anticancer Potential of Active Compounds from Galangal (Alpinia galanga)

Targeting Cell Signaling Pathways in Lung Cancer by Bioactive Phytocompounds

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