In vitro and in vivo study of pH-sensitive and colon-targeting P(LE-IA-MEG) hydrogel microspheres used for ulcerative colitis therapy

Shi, Xianpeng; Yan, Yan; Wang, Pengchong; Ying, Sun; Zhang, Di; Zou, Yamin; Hu, Sasa; Zhang, Lu; Xing, Jianfeng; Dong, Yalin

doi:10.1016/j.ejpb.2017.10.003

Cited by 19 publications

(5 citation statements)

References 25 publications

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“…Micro-or nanopatterning can also be used to study and understand the cellular responses to RNAi (Lee and Koh, 2014;Jeon et al, 2018;Li et al, 2019). Furthermore, a drug release signal could also be fabricated into hydrogel to improve responsiveness, such as pH (Hossieni-Aghdam et al, 2018;Shi et al, 2018), temperature (Amoli-Diva et al, 2017;Turabee et al, 2018;Wang P. et al, 2018), stress (Chaudhuri et al, 2016;Wei et al, 2018), enzymatic activity (Lian et al, 2016;Skaalure et al, 2016), and light (Song et al, 2015;Rastogi et al, 2018). An appropriate administration time might enhance the effectiveness of RNAi therapy and help to promote the clinical application of hydrogel RNAi therapy for bone regeneration.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

Wang

Zhang

et al. 2020

Front. Bioeng. Biotechnol.

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RNA interference (RNAi) is an efficient post-transcriptional gene modulation strategy mediated by small interfering RNAs (siRNAs) and microRNAs (miRNAs). Since its discovery, RNAi has been utilized extensively to diagnose and treat diseases at both the cellular and molecular levels. However, the application of RNAi therapies in bone regeneration has not progressed to clinical trials. One of the major challenges for RNAi therapies is the lack of efficient and safe delivery vehicles that can actualize sustained release of RNA molecules at the target bone defect site and in surrounding cells. One promising approach to achieve these requirements is encapsulating RNAi molecules into hydrogels for delivery, which enables the nucleic acids to be delivered as RNA conjugates or within nanoparticles. Herein, we reviewed recent investigations into RNAi therapies for bone regeneration where RNA delivery was performed by hydrogels.

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Section: Conclusion and Future Perspectivementioning

confidence: 99%

The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

Wang

Zhang

et al. 2020

Front. Bioeng. Biotechnol.

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“…Future research is thus required to design strategies that would upregulate the expression of VDR thereby facilitating therapeutic approaches that implements vitamin D for treatment of IBD. Shi et al (2018) conducted in vitro and in vivo study using pH-sensitive and colon-targeting P(LE-IA-MEG) hydrogel microspheres for UC therapy. Anti-inflammatory drug hydrocortisone sodium succinate (HSS) was combined with pH-sensitive (PLE-IA-MEG) hydrogel microspheres (HMSs) as the drug carrier for the treatment of UC.…”

Section: Colonic Drug Delivery and Its Physiological Landscapementioning

confidence: 99%

Significance of Ligand-Anchored Polymers for Drug Targeting in the Treatment of Colonic Disorders

2020

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Treatment of a variety of bowel diseases like Crohn's disease, ulcerative colitis, colonic cancers, colonic pathologies, and systemic delivery of drugs at the target sites can be done with the help of targeted drug delivery technique. Conventional colon specific drug delivery systems lack specificity and release significant amount of drug prior reaching the target site. Hence, efficient drug delivery system that ensures effective release of the drug at the colon is still a sought after research arena. Ligand anchored therapy is a strong and effective approach to execute drug delivery in selective target cells, for both, diagnostic, as well as therapeutic reasons. Compared to the regular drugs, such ligand anchored therapy provides added benefit of minimum toxicity and few side effects. Discovery of overexpressed receptors on diseased cells, as compared to healthy cells led to the emergence of active drug targeting. Further, drug resistance constitutes one of the major reasons of the failure of chemotherapy and presents a major obstacle for the effective treatment. The reason behind drug resistance is exposure of pathological cells/pathogens to sub-therapeutic levels of drugs due lack of specificity of therapeutics. Active targeting, specifically taken up by the target cells, can warrant exposure of pathological cells/ pathogens to high drug load at the target and sparing non-target cells hence minimal damage to normal cells and least chance of drug resistance. Many ligands like antibodies, aptamers, peptides, folate, and transferrin have been discovered in the past few years. The design of nanocarriers can be incorporated with many different functions which enables functions like imaging and triggered intracellular drug release. The present review article focuses on advances in ligand anchored therapy and its significance on the progress of targeted nanocarriers. It will also establish novel concepts like multitargeting and multi-functional nanocarriers for the treatment of colonic disorders.

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“…ThermocoatL30D55 a pH sensitive polymer hasbeen reportedtoimprovethe shelf life of pellets, granules and powders and to improve selfprotection against environmental effects like humidity, light, temperature, which was used to develop pH dependent Tulsion® microspheres for colon specific delivery using quasi emulsion spherical crystallization technique and a combined mechanism of release, which combines specific biodegradability of polymer and pH dependent release from the coated microspheres was proposed [4]. Shi et al [7] studied about pH-sensitive and colon-targeting P(LE-IA-MEG) hydrogel microspheres used for ulcerative colitis therapy and demonstrated desirable colon targeting property from The pharmacokinetic studies. Agrawal et al [8] Formulated separately colon targeted pH pendent microspheres using pHsensitive polymer Eudragit L100, S100 of capecitabine for colorectal cancer to reduce dosing frequency and improve patient compliance.…”

Section: Nanoparticles/ Microparticles/microspheresmentioning

confidence: 99%

Colon Targeting Using pH Sensitive Materials

Jain¹

2018

ARGH

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The oral route is the preferred route for drug delivery, among oral delivery Intestine and colon drug delivery have been used for molecules aimed at local treatment of colonic diseases such as Colon Cancer, Polyp, Colorectal, Crohn's Disease, Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC) etc. and for delivery of molecules susceptible to enzymatic degradation such as peptides. There are various methods have been reported for colon targeting, among them use of pH sensitive polymers for coating and formulation of drug delivery system is most beneficial. The formulations of pH sensitive nanoparticles, hydrogel, microspheres, Polymeric Micelles are commonly reported for colon targeting. This review focuses on advancements of pH sensitive drug delivery system for colon targeting.

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In vitro and in vivo study of pH-sensitive and colon-targeting P(LE-IA-MEG) hydrogel microspheres used for ulcerative colitis therapy

Cited by 19 publications

References 25 publications

The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

The Delivery of RNA-Interference Therapies Based on Engineered Hydrogels for Bone Tissue Regeneration

Significance of Ligand-Anchored Polymers for Drug Targeting in the Treatment of Colonic Disorders

Colon Targeting Using pH Sensitive Materials

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