In vitro and in vivo studies on as-extruded Mg- 5.25wt.%Zn-0.6wt.%Ca alloy as biodegradable metal

Gu, Xuenan; Wenxin, Fan; Xie, Xinhui; Zheng, M.Y.; Li, Ping; Zheng, Yufeng; Qin, Ling; Fan, Yubo

doi:10.1007/s40843-017-9205-x

Cited by 28 publications

(15 citation statements)

References 44 publications

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“…Gu et al found that Mg-Zn-Ca alloys increased the bone formation and the density of the bone upon implantation. 32 In the present study, a degradation rate between those of LAE442 and Mg-La2 could be realized using the ZX61 alloy. Furthermore, only a thin corrosion layer was observed in the in vitro experiments.…”

Section: Discussionmentioning

confidence: 70%

Magnesium Alloys for Open-Pored Bioresorbable Implants

Maier

Julmi

Behrens

et al. 2020

JOM

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If bone defects occur, the body's own healing mechanism can close them below a critical size; for larger defects, bone autografts are used. These are typically cut from the same person's hip in a second surgery. Consequently, the risk of complications, such as inflammations, rises. To avoid the risks resulting from the second surgery, absorbable, open-pored implants can be used. In the present study, the suitability of different magnesium alloys as absorbable porous bone substitute material has been investigated. Using the investment casting process with its design flexibility, the implant's structure can be adapted to the ideal pore geometry with respect to bone ingrowth behavior. Different magnesium alloys (Mg-La2, LAE442, and ZX61) were studied and rated in terms of their degradation rate, bone ingrowth behavior, biocompatibility, and resorbability of the individual alloying elements.

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Section: Discussionmentioning

confidence: 70%

Magnesium Alloys for Open-Pored Bioresorbable Implants

Maier

Julmi

Behrens

et al. 2020

JOM

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“…However, in terms of biocompatibility and osteoconductivity, the implant got integrated into the surrounding bone tissue after only 2 months, suggesting its good biocompatibility. Gu et al (2018) investigated the corrosion and the biocompatibility of the newly developed Mg-5.25Zn-0.6Ca alloy for the purpose of orthopaedic applications. The in vivo results revealed a promising biocompatibility with an enhanced new bone formation due to an increase in the Mg ion concentration which in combination with the local increased pH, lead to an improved nucleation rate of apatite and mineralization.…”

Section: Mg-alloysmentioning

confidence: 99%

In vitro and in vivo biological performance of Mg-based bone implants

Negrescu¹,

Necula²,

Costache³

et al. 2020

Rev. Biol. Biomed. Sci.

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With the rapid advancement of medical technology, it is crucial that a considerable body of biomaterials are taken into consideration and tested for the purpose of bone implant fabrication. Over the last decades degradable metallic materials have attracted increasing interest in the field of hard tissue engineering due to their ability to degrade once they have fulfilled their function, without causing side effects that could potentially be harmful for the human body. In this context, Mg-based biomaterials gained special attention due to their bone-like mechanical properties, good biocompatibility and osteoconductive properties. However, their use in biomedical applications is limited due to their rapid corrosion in physiological environments. Therefore, it is important to reduce the degradation process of these biomaterials for safe biomedical applications. Two main strategies that could potentially lead to a lower corrosion rate are represented by alloying and surface treatment. This review provides a summary of the recent specialized literature concerning Mg-based biomaterials with a special focus on the recent in vitro and in vivo studies regarding Mg-based bone implants.

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“…Wang et al 41 reported the combined effects of the loss of LTRPC7 function and the decrease of Ca involved binding sites/reactions in high Mg level, which may inuence the cell viability. 42 10-15 mM of Mg ion concentration is reported to be the critical dose without inhibiting cell viability. Aer 50% dilution, the concentration of Mg is approximately 15 mM for Sr-HA coating extracts which is in the range of the biosafety level recommended in the previous study, 41 while 26 mM of Mg is observed for the uncoated samples.…”

Section: Cell Biocompatibility Of Sr-ha Coated Mg Alloymentioning

confidence: 99%