In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses

Soromou, Lanan Wassy; Chu, Xiao; Jiang, Lanxiang; Wei, Miaomiao; Huo, Meixia; Chen, Na; Guan, Shuang; Yang, Xiaofeng; Chen, Chengzhen; Feng, Hailan; Deng, Xuming

doi:10.1016/j.intimp.2012.06.009

Cited by 107 publications

(72 citation statements)

References 38 publications

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“…Pretreatment using pinocembrin (10) also decreased the concentrations of TNF-α, IL-1 β, IL-6 and increased IL-10 levels. Parallel in vitro experiments suggested that the mitigation of LPS-induced ARDS by this flavonoid is a result of the suppression of Iκ α, JNK and p38MAPK activation [102].…”

Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 93%

Structure-Activity Association of Flavonoids in Lung Diseases

et al. 2014

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Flavonoids are polyphenolic compounds classified into flavonols, flavones, flavanones, isoflavones, catechins, anthocyanidins, and chalcones according to their chemical structures. They are abundantly found in Nature and over 8,000 flavonoids have from different sources, mainly plant materials, have been described. Recently reports have shown the valuable effects of flavonoids as antiviral, anti-allergic, antiplatelet, antitumor, antioxidant, and anti-inflammatory agents and interest in these compounds has been increasing since they can be helpful to human health. Several mechanisms of action are involved in the biological properties of flavonoids such as free radical scavenging, transition metal ion chelation, activation of survival genes and signaling pathways, regulation of mitochondrial function and modulation of inflammatory responses. The anti-inflammatory effects of flavonoids have been described in a number of studies in the literature, but not frequently associated to respiratory disease. Thus, this review aims to discuss the effects of different flavonoids in the control of lung inflammation in some disorders such as asthma, lung emphysema and acute respiratory distress syndrome and the possible mechanisms of action, as well as establish some structure-activity relationships between this biological potential and chemical profile of these compounds.

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Section: Acute Respiratory Distress Syndrome (Ards)mentioning

confidence: 93%

Structure-Activity Association of Flavonoids in Lung Diseases

et al. 2014

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“…1A), one of the primary flavonoids from Pinus heartwood and Eucalyptus, has been reported to have a variety of pharmacological activities such as anti-inflammatory and antioxidant activities (Saad et al, 2015). Previous studies showed that pinocembrin inhibited LPS-induced TNF-α, IL-1β and IL-6 production in RAW264.7 cells in vitro (Soromou et al, 2012). Pinocembrin also attenuated 6-OHDA-induced neuronal cell death in SH-SY5Y cells (Jin et al, 2014).…”

Section: Introductionmentioning

confidence: 98%

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

Zhou

Wang

et al. 2015

European Journal of Pharmacology

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“…Flavonoids can also be involved in plant defense mechanisms. Specifically, antioxidant activity has been reported for pinobanksin and pinocembrin (Neacsu et al 2007), whereas the ability to modulate inflammatory responses in vitro has been claimed for the latter (Soromou et al 2012). Pinocembrin protects neurons against beta-amyloid-induced toxicity and has been predicted to have a number of biological activities, including anti-HIV action (Maridass et al 2008).…”

Section: Introductionmentioning

confidence: 99%

Water-Soluble Components of Pinus pinaster Wood

Conde¹,

Fang²,

Hemming³

et al. 2013

BioResources

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Aqueous fractionation of wood has been proposed as a suitable processing method for biorefineries. When treatments are performed under low severity conditions, water-soluble components (which could be detrimental in further processing stages) are removed, whereas polysaccharides, lignin, and other water-insoluble constituents remain in solid phase with little alteration. In order to explore the presence of added-value products in aqueous extracts from Pinus pinaster wood, different samples (heartwood and sapwood with and without knots) were extracted with water at 130 to 140 ºC, and the resulting solutions were assayed for yield and composition (by GC-FID, GC-MS, and HPLC). The major extract components, such as polysaccharide-derived products, simple phenolics, stilbenes, lignans, flavonoids, organic acids, jubaviones, steryl esters, and triglycerides, were identified and quantified. In order to assess a possible application of the extracts, their antioxidant activity was measured using the Trolox Equivalent Antioxidant Capacity assay.

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In vitro and in vivo protection provided by pinocembrin against lipopolysaccharide-induced inflammatory responses

Cited by 107 publications

References 38 publications

Structure-Activity Association of Flavonoids in Lung Diseases

Structure-Activity Association of Flavonoids in Lung Diseases

Pinocembrin inhibits lipopolysaccharide-induced inflammatory mediators production in BV2 microglial cells through suppression of PI3K/Akt/NF-κB pathway

Water-Soluble Components of Pinus pinaster Wood

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