In vitro and in vivo analyses of the effects of desensitizing agents on dentin permeability and dentinal tubule occlusion

Pinto, Shelon Cristina Souza; Pochapski, Márcia Thaís; Wambier, Denise Stadler; Pilatti, Gibson Luiz; Santos, Fábio André dos

doi:10.2334/josnusd.52.23

Cited by 28 publications

(30 citation statements)

References 24 publications

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“…5 A rational approach to the control of pain arising from exposed dentin would thus be to block the tubules or to reduce their diameter. [5][6][7][8] Ideally, a treatment for dentin hypersensitivity, as well as for other problems, should be quick and simple. Thus, the use of special toothpastes has been largely embraced as one of the first alternatives.…”

Section: Introductionmentioning

confidence: 99%

Effect of desensitizing toothpastes on dentin

et al. 2012

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The objective of this study was to analyze the effects of toothbrushing with desensitizing toothpastes on dentin permeability and dentinal tubule occlusion. Fifty rats provided two hundred incisor teeth divided into five groups: DW, brushed with distilled water (control); FT, brushed with fluoride toothpaste; SCT, brushed with strontium chloride toothpaste; PCT, brushed with potassium citrate toothpaste; and PNT, brushed with potassium nitrate toothpaste. Cavities were prepared to expose the dentinal tubules, and the incisor teeth were brushed using the experimental agents. After each treatment, Evans blue dye solution was applied to the teeth. Dentin permeability was analyzed using scanning electron microscopy and energy-dispersive X-rays (EDX). There were significant differences (p < 0.0001, ANOVA) among the groups regarding dentin permeability, number of dentinal tubules, diameter of dentinal tubules, and opened tubular area. In the SCT, PCT and PNT groups, opened and partially occluded tubules, deposits, and a few smear layers were observed. In the DW and FT groups, most of the dentinal tubules were open, with no deposits or smear layers on the dentin. EDX revealed peaks of calcium and phosphorus in all of the groups, as well as traces of strontium in the SCT group and of potassium in the PCT and PNT groups. Desensitizing toothpaste decreased dentin permeability, although it produced only partial dentin tubule occlusion.

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Section: Introductionmentioning

confidence: 99%

Effect of desensitizing toothpastes on dentin

et al. 2012

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“…31 Earlier studies have prescribed the repeated usage of desensitizing agents to ensure higher clinical effectiveness in dentinal tubule occlusion. 13 In this study, activating the dentifrices with Er,Cr:YSGG after brushing for 6 minutes and analyzing through SEM reveals diminished tubule diameter of 660 nm as opposed to 5-day application when using dentifrice alone. The chromophore for Er,Cr:YSGG is water, hence, this laser is equally applicable for soft and hard tissue procedures.…”

Section: Discussionmentioning

confidence: 99%

“…The success of desensitizing agents is directly proportional to its ability to seal or occlude the dentinal tubules and reduce the diameter of the opened tubules thereby decreasing the hydrodynamic pain transmission mechanism. 13 The scope of modification of causative factors in the management of dentinal hypersensitivity is one which is grossly overlooked. 14 The oral environment being dynamic, the desensitizing agent has to withstand the challenges of salivary dissolution, acid attack from microbes and food components as well as chemical, mechanical and thermal trauma to provide long-lasting pain relief for the patient.…”

Section: Introductionmentioning

confidence: 99%

In vitro Analysis Comparing Efficacy of Lasers and Desensitizing Agents on Dentin Tubule Occlusion: A Scanning Electron Microscope Study

Iyer¹,

Nandakumar²

2014

International Journal of Laser Dentistry

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Dentinal hypersensitivity (DH), one of the commonest causes of dental pain, arises from exposure of dentinal tubules most commonly in the cervical region of the buccal and facial surfaces of the tooth in response to typically thermal, evaporative, tactile, osmotic or chemical stimulus. This study aims at evaluating the efficacy of Er,Cr:YSGG (dual lasers -hard and soft tissue) and diode lasers (soft tissue lasers) against clinically proven dentifrices prescribed by dentists, easily available over the counter, in treating DH. In 60 recently extracted human teeth, cervical cavities were prepared and etched with 17% EDTA to expose the tubules and eliminate smear layer. The teeth were further divided into groups: Er,Cr:YSGG laser, diode laser and commonly used dentifrices chosen on the basis of previous studies. After treatment, the teeth were subjected for scanning electron microscope (SEM) analysis on the same day for quantitative and qualitative analysis of the specimens. Quantitative analysis of the SEM images was done using image analysis software. Er,Cr:YSGG showed superior results in terms of number of tubules per millimeter square, tubule diameter and tubular area. Laser treatment of exposed dentinal tubules with Er,Cr:YSGG promises a noninvasive, pain free and relatively safe treatment option.

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“…Occluding dental tubular agents can create a barrier by precipitating proteins and calcium/ phosphate ions on the surface or within the tubule orifice. 9 The degree of desensitizing activity increases with the increase of depth of penetration, because if the penetration level is less, there is chance of removal of deposits by brushing or dietary acids, but if the penetration level is more within the dentinal tubule, the brushing or dietary acids can't easily remove it; it can occlude the dentinal tubule better and thereby give more desensitizing effect. 10 The SEM study showed a wide range of depth of penetration within the dentinal tubule.…”

Section: Discussionmentioning

confidence: 99%

Comparative Evaluation of the Depth of Penetration of different Types of Desensitizing Agents into the Dentinal Tubules: An in vivo Study

Mitra¹,

Adhikari²

2017

Journal of Contemporary Dentistry

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Aim: Aim of the study is to evaluate the depth of penetration of different types of desensitizing agents into the dentinal tubules in vivo. Materials and methods:Twenty patients requiring tooth extraction for orthodontic purpose were selected. In all four premolars of the selected patients, small class V cavities were prepared on the buccal surface having depth of 0.5 mm. They were divided into four groups and treated with four different types of desensitizing agents (5% NaF solution, Gluma desensitizer, FluorProtector, and SuperSeal) for required time and then they were extracted. They were longitudinally sectioned and each section was studied by scanning electron microscope. Results:The mean depth of penetration of SuperSeal and Gluma was significantly higher than that of other agents (sodium fluoride and FluorProtector) (p<0.05). No significant difference was found between SuperSeal and Gluma (p>0.05). Conclusion:The depth of penetration of resinous desensitizing agent (Gluma) is maximum followed by potassium oxalate solution (SuperSeal) and fluoride varnish (FluorProtector). Clinical significance:Deeper the penetration of desensitizing agents into the dentinal tubules, longer the efficacy.

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In vitro and in vivo analyses of the effects of desensitizing agents on dentin permeability and dentinal tubule occlusion

Cited by 28 publications

References 24 publications

Effect of desensitizing toothpastes on dentin

Effect of desensitizing toothpastes on dentin

In vitro Analysis Comparing Efficacy of Lasers and Desensitizing Agents on Dentin Tubule Occlusion: A Scanning Electron Microscope Study

Comparative Evaluation of the Depth of Penetration of different Types of Desensitizing Agents into the Dentinal Tubules: An in vivo Study

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