In vitro and in vivo evaluation of the influences of polysaccharides derived from Glycyrrhiza uralensis on three alkaloids and potential interaction mechanisms

Sun, Lili; You, Guangjiao; Zheng, Fuxiang; Wang, Meng; Ren, Xiaoliang; Deng, Yanru

doi:10.1016/j.ijbiomac.2020.04.140

Cited by 6 publications

(1 citation statement)

References 24 publications

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“…In recent years, an increasing body of literature suggests that natural polysaccharides may exhibit interactions with small molecule active components, [9][10][11] thereby potentially contributing to their therapeutic potential in the treatment of various diseases. For instance, it has been reported that glycyrrhiza polysaccharides can enhance the efficacy of active components present in aconite, 12 while cistanche polysaccharides may enhance the absorption of pineal glycosides. 13 Consequently, natural polysaccharides may play a crucial role in improving the hydrophily and bioavailability of insoluble components.…”

Section: Introductionmentioning

confidence: 99%

A Multi-Component Nano-Co-Delivery System Utilizing Astragalus Polysaccharides as Carriers for Improving Biopharmaceutical Properties of Astragalus Flavonoids

Yang,

Wu,

Zeng

et al. 2023

IJN

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Enhancing the dissolution, permeation and absorption of active components with low solubility and poor permeability is crucial for maximizing therapeutic efficacy and optimizing functionality. The objective of this study is to investigate the potential of natural polysaccharides as carriers to improve the biopharmaceutical properties of active components. Methods: In this study, we employed four representative flavonoids in Astragali Radix, namely Calycosin-7-O-β-D-glucoside (CAG), Ononin (ON), Calycosin (CA) and Formononetin (FMN), as a demonstration to evaluate the potential of Astragalus polysaccharides (APS) as carriers to improve the biopharmaceutical properties, sush as solubility, permeability, and absorption in vivo. In addition, the microstructure of the flavonoids-APS complexes was characterized, and the interaction mechanism between APS and flavonoids was investigated using multispectral technique and molecular dynamics simulation. Results:The results showed that APS can self-assemble into aggregates with a porous structure and large surface area in aqueous solutions. These aggregates can be loaded with flavonoids through weak intermolecular interactions, such as hydrogen bonding, thereby improving their gastrointestinal stability, solubility, permeability and absorption in vivo. Conclusion:We discovered the self-assembly properties of APS and its potential as carriers. Compared with introducing external excipients, the utilization of natural polysaccharides in plants as carriers may have a unique advantage in enhancing dissolution, permeation and absorption.

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