In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn

Ghule, B.V.; Yeole, P. G.

doi:10.1016/j.jep.2012.03.005

Cited by 40 publications

(30 citation statements)

References 24 publications

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“…A number of Indian medicinal plants of Ayurvedic origin have been experimentally claimed to possess immunomodulatory activity [3,66]. They activate humoral as well as cellular arms of the immune system of the host [59] through the stimulation of natural killer cells, B cells, T cells, and macrophage-dependent immune responses [5,34,35,53]. In addition to the growing concern on the research on plant extracts, there is also a rising interest on the action of isolated bioactive compounds on immunological liver injury.…”

Section: Introductionmentioning

confidence: 99%

Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action

Duggina

Kalla

Varikasuvu³

et al. 2015

J Physiol Biochem

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This study was designed to investigate the protective effects of the centella triterpene saponins (EXT) on cyclophosphamide (CYP)-induced hepatotoxicity and immunosuppression in rats. The phytochemical profile of EXT was analyzed for centella saponins by using high-performance liquid chromatographic (HPLC). Therapeutic efficacy of EXT (250 mg/kg/day p.o) on hematological profile of blood, liver function markers, and cytokine profiles in CYP (10 mg/kg/day p.o)-treated rats. In addition, weights of immune organs (spleen and thymus) and histopathological changes in the liver, intestine, and spleen were also evaluated. The active principles in EXT were identified as madecassoside, asiaticoside, and asiatic acid by HPLC analysis. Upon administration of EXT, enhanced levels of glutamate pyruvate transaminase, alkaline phosphatase, and lipid peroxidation were found reduced while the levels of reduced glutathione and hematological parameters and relative weights of immune organs were restored to normal in CYP-treated rats. The hepatic mRNA level of TNF-α, which was increased during CYP administration, was significantly decreased by the EXT treatment. The decreased levels of mRNA expression of other cytokines like IFN-γ, IL-2, GM-CSF, after CYP treatment, were also found elevated upon administration of the EXT. Histopathological examination of the intestine, liver, and spleen indicated that the extract could attenuate the CYP-induced hepatic and immune organ damage. These results indicated that EXT modulated the immune and hepatic system function of rats against CYP-induced immunosuppression and hepatotoxicity by restoring the cytokine production, antioxidant system, and multiorgan injury. Thus, triterpene saponins may provide protective and/or therapeutic alternative against the immune-mediated liver diseases.

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Section: Introductionmentioning

confidence: 99%

Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action

Duggina

Kalla

Varikasuvu³

et al. 2015

J Physiol Biochem

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“…Herbal drugs possess immunomodulatory characteristics and normally act by suppressing or stimulating both specific and nonspecific immunities 4. A number of plants used in conventional medicines have been found to possess immunomodulating activities such as Barleria prionitis ,5 Tinospora cordifolia ,6 Withania somnifera ,7 Chenopodium ambrosioides ,8 Actaea racemosa ,9 Asparagus racemosus ,10 Cyrtomium macrophyllum ,11 Phyllanthus amarus , Phyllanthus urinaria ,12 and Uncaria perrottetii 1314 and Mangifera indica have been shown to change the immune function and possess a range of immunomodulatory effects.…”

Section: Introductionmentioning

confidence: 99%

Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

Ahmad

Jantan

Kumolosasi

et al. 2015

DDDT

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Tinospora crispa (TC) has been used in folkloric medicine for the treatment of various diseases and has been reported for several pharmacological activities. However, the effects of TC extract on the immune system are largely unknown. Therefore, the present study was aimed to investigate the immunomodulatory effects of a standardized 80% ethanol extract of the stem of TC on innate immune responses. Male Wistar Kyoto rats were treated daily at 100 mg/kg, 200 mg/kg, and 400 mg/kg doses of the extract for 21 days by oral gavage. The immunomodulatory potential of TC was evaluated by determining its effect on chemotaxis and phagocytic activity of neutrophils isolated from the blood of rats. To further elucidate the mechanism of action, its effects on the proliferation of T- and B-lymphocytes and T-lymphocytes subsets (CD4+ and CD8+) and on the secretion of Th1 and Th2 cytokines were also monitored. The main components of the extracts, syringin and magnoflorine, were identified and quantitatively analyzed in the extracts by using a validated reversed-phase high-performance liquid chromatography method. It was observed that the chemotactic activity of neutrophils obtained from extract-treated rats increased as compared to controls. A dose-dependent increase in the number of migrated cells and phagocytosis activity of neutrophils was observed. Dose-dependent increase was also observed in the T- and B-lymphocytes proliferation stimulated with concanavalin A (5 μg/mL) and lipopolysaccharide (10 μg/mL), and was statistically significant at 400 mg/kg (P>0.01). Apart from cell-mediated immune response, the concentrations of Th1 (TNF-α, IL-2, and IFN-γ) and Th2 (IL-4) cytokines were significantly increased in sera of rats treated with different doses as compared with the control group. From these findings, it can be concluded that TC possesses immunostimulatory activity and has therapeutic potential for the prevention of immune diseases.

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“…Similar to this study, Jeong et al (2011) reported that known compounds of samnamul were identified as kaempferol 3-O-b-D-glucoside, quercetin-3-O-b-D-glucopyranoside, kaempferol 3-O-b-D-(6-E-p-coumarylglucoside) and so on. Besides these compounds, shanzhiside methyl ester was functional iridoid glycosides and can be isolated from some herbs including Barleria prionitis (Ghule & Yeole, 2012), Lamiophlomis rotata (Fan et al, 2016) and so on. Sergeolide was a quassinoid from plant, and its high antimalarial activity was investigated by many studies (O'Neill et al, 1986).…”

Section: Phenolic Compoundsmentioning

confidence: 99%

Effect of water blanching on phenolic compounds, antioxidant activities, enzyme inactivation, microbial reduction, and surface structure of samnamul (Aruncus dioicus var kamtschaticus)

Kim

Lee

Rahman

et al. 2019

Int J of Food Sci Tech

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Summary Water blanching is widely used in food industry, but imprudent process causes considerable quality deterioration. To determine optimum condition, the effect of water blanching at different temperature (80, 90 and 98 °C) and time (0–10 min) on the characteristics of samnamul was investigated. Total phenolic and flavonoid content and antioxidant activities showed dramatic increase up to maximum and decreased rapidly as further blanching prolonged at all temperatures. The blanching at 98 °C for 30 s showed the highest values of them. Phenolic compounds such as shanzhiside methyl ester, isoquercetin, quercetin 3‐O‐rhamnoside, kaempferol 3‐O‐glucoside and sergeolide showed different temperature dependence. At 30 s, quercetin derivatives levels increased with increasing temperature and showed highest heat‐stability. Based on our study, the blanching at high temperature of 98 °C for a short time of 30 s may be important to increase or maintain nutritional quality, while oxidative enzyme activities and the microorganism numbers decreased.

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In vitro and in vivo immunomodulatory activities of iridoids fraction from Barleria prionitis Linn

Cited by 40 publications

References 24 publications

Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action

Protective effect of centella triterpene saponins against cyclophosphamide-induced immune and hepatic system dysfunction in rats: its possible mechanisms of action

Immunostimulatory effects of the standardized extract of Tinospora crispa on innate immune responses in Wistar Kyoto rats

Effect of water blanching on phenolic compounds, antioxidant activities, enzyme inactivation, microbial reduction, and surface structure of samnamul (Aruncus dioicus var kamtschaticus)

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