In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate

Hilton, Alan K.; Deasy, P. B.

doi:10.1016/0378-5173(92)90033-x

Cited by 102 publications

(60 citation statements)

References 17 publications

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“…Effervescent system [39][40] Effervescent systems include use of gas generating agents, carbonates (sodium bicarbonate), and other organic acids (citric acid and tartaric acid) to produce carbon dioxide (CO 2 ) gas, thus reducing the density of the system and making it to float on the gastric fluid. These effervescent systems further classified into two types.…”

Section: Types Of Fddsmentioning

confidence: 99%

“…A multi-unit type oral floating dosage system [40] Figure 5: Stages of floating mechanisms [40] Figure 6: Intragastric floating gastrointestinal drug delivery device [39] Figure 7: Inflatable gastrointestinal delivery system [22] The floating support is also contains a bioerodible plug that erodes after a predetermined time to deflate the support. The deflated drug delivery system is then emptied from the stomach [ Figure 8].…”

Section: Figurementioning

confidence: 99%

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Katiyar

2017

AJP

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Floating drug delivery systems (FDDS) are controlled release drug delivery systems, which get retained in the stomach for longer periods, thus helping in absorption of drug for the intended duration of time. Gastricretentive drug delivery devices can be useful for the spatial and temporal delivery of many drugs. In general, drugs with narrow therapeutic window and prone to degradation in intestine and colon along with drugs having low retention time in gastrointestinal tract (GIT) are selected for FDDS which helps drugs to stay long time in stomach thus increasing gastric residence time and reduces dosing frequency. The present review article shows the various methods of FDDS for increasing retention time of drugs in GIT.

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Section: Types Of Fddsmentioning

confidence: 99%

Section: Figurementioning

confidence: 99%

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Katiyar

2017

AJP

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“…[4,5] Most popular approach of oral controlled drug delivery is gastroretentive drug delivery system (GRDDS) drug delivery system one. GRDDS plays a key role among novel drug delivery systems.…”

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confidence: 99%

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Nawaj¹

2017

AJP

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Aim: The objectives of this investigation were to develop gastroretentive floating bioadhesive drug delivery for simvastatin to increase gastric residence time and reduce the dose frequency. To explore Badams gum's sticking property in floating bioadhesive drug delivery of simvastatin. Materials and Methods: Floating bioadhesive tablet was formulated with Badam gum and hydroxypropyl methylcellulose (HPMC) K 15 M polymers, sodium bicarbonate, and citric acid as the gas generating agents to reduce floating lag time. Tablets were prepared by direct compression method. Optimization study was conducted using 3 2 factorial design. The concentration of polymers was considered as independent variables whereas swelling index, bioadhesive strength and % drug release at 10 h, of the tablets were utilized as dependent variables. Results and Discussions: Preformulation study suggests powders blends shows acceptable flow properties. Simvastatin floating-bioadhesive tablet found to be good without chipping, capping, and sticking. Comparing all the formulations, A5 optimized formulation exhibited 98.10 ± 2.10% of drug release in 12 h, floating lag time of 34 ± 3 s, with appropriate bioadhesive property, and total floating time of over 12 h. It was observed that increasing percentage of polymer in formulation the drug release decreased. Developed formulations were stable during stability studies. Conclusion: Based on these findings, it was concluded that Badam gum can be used as a bioadhesive as well as release retarding polymer for the floating bioadhesive dosage form of other drugs.

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“…Further, low plasma protein binding (20%) and very low t 1/2 (1-1.5 hours) and lack of stability in gastric acidic pH calls for the design of novel pharmaceutical formulations (Wilson, Lee, Mukherji, 2002). Several formulation approaches have been explored to develop sustained release dosage forms of AMT to address the above-mentioned problems (Bonev, Hopper, Parisot, 2008;Hilton, Deasy, 1992;Patel, Amiji, 1996;Risbud, Hardikar, Bhat, 2000). The novel time-dependent release bilayer tablets comprised of a delayed release layer (i.e., Eudragit-L100 D55 as pH dependent enteric polymer which releases the drug after specific lag-time), and a sustained release layer (i.e., HPMCK4M and HPMCK15).…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity assessment of time-dependent release bilayer tablets of amoxicillin trihydrate

Beg

Nayak

Kohli

et al. 2012

Braz. J. Pharm. Sci.

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The aim of present study was the assessment of antimicrobial activity of prepared time-dependent release bilayer tablets of amoxicillin trihydrate and in vitro evaluation of drug release by antimicrobial assay using agar plate diffusion method. The bilayer tablets comprised of a delayed and sustained release layer. Direct compression method was used for the preparation of bilayer tablets containing Eudragit-L100 D55 as delayed release polymer, and HPMCK4M and HPMCK15 as sustained release polymers. The prepared bilayer tablets containing amoxicillin trihydrate were evaluated for hardness, thickness, friability, weight variation and drug content. Further, in vitro drug release was assessed by antimicrobial assay using S. aureus and E. coli as test microorganisms. The aliquot samples of in vitro drug release study were found to be effective against both microorganisms for 16 hours due to sustained action. The in vitro drug release study and antimicrobial assay showed that bilayer tablets have sustained release profile of drug delivery with time-dependent burst release after a lag-time of 2 hours. The lower MIC value (2 µg/mL) of prepared bilayer tablets vis-à-vis marketed preparation (5 µg/mL) represented its good antimicrobial activity. Uniterms:Chronotherapeutics. Time-dependent release. In vitro dissolution. Minimum inhibitory concentration. Zone of inhibition.O objetivo do presente estudo foi avaliar a atividade antimicrobiana de formulações de comprimidos de dupla camada contendo amoxicilina triidratada para liberação tempo dependente e avaliação da liberação in vitro do fármaco pelo ensaio de atividade antimicrobiana utilizando o método de difusão em placa de ágar. Os comprimidos de dupla camada consistem em uma camada para liberação retardada e outra sustentada. O método de compressão direta foi usado para a preparação dos comprimidos de dupla camada contendo Eudragit-L 100 D55 como polímero para liberação retardada e HPMCK4M ou HPMCK15 como polímeros para liberação sustentada. As formulações de comprimidos de dupla camada contendo amoxicilina triidratada foram avaliadas quanto a dureza, espessura, friabilidade, variação de peso e conteúdo de fármaco. Além disso, a liberação do fármaco in vitro foi avaliada por ensaio de atividade antimicrobiana usando S. aureus e E. coli como microrganismos teste. A alíquota das amostras do estudo de liberação do fármaco in vitro demonstrou ser efetiva contra ambos os microrganismos por um período de 16 horas devido à ação sustentada. O estudo de liberação do fármaco in vitro e o ensaio de atividade antimicrobiana mostraram que os comprimidos de dupla camada tiveram um perfil de liberação sustentada do fármaco com um pico de liberação após 2 horas de ensaio. O menor valor de MIC (2 ug/mL) dos comprimidos de dupla camada quando comparados à formulação comercial (5 ug/ mL) representa uma boa atividade antimicrobiana. Unitermos:Cromoterapia. Liberação tempo-dependente. Dissolução in vitro. Concentração inibitória mínima. Zona de inibição.

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In vitro and in vivo evaluation of an oral sustained-release floating dosage form of amoxycillin trihydrate

Cited by 102 publications

References 17 publications

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Antimicrobial activity assessment of time-dependent release bilayer tablets of amoxicillin trihydrate

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