In vitro and in vivo bactericidal activities of 10%, 2.5%, and 1% povidone-iodine solution

Ghogawala, Zoher; Furtado, D

doi:10.1093/ajhp/47.7.1562

Cited by 7 publications

(7 citation statements)

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“…5 This killing effect can occur in 15 seconds. 6 Another important effect of PVI is the tumoricidal effect, which was reported by Umpleby and Williamson 3 in 1984, but the details of this mechanism were not clearly described.…”

mentioning

confidence: 98%

Benefits of Povidone-Iodine Solution in Colorectal Operations: Science or Legend

Pattana-arun¹,

Wolff²

2008

Diseases of the Colon &Amp; Rectum

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Povidone-iodine solution (Betadine) has long been accepted as an effective topical broad spectrum antiseptic, disinfectant, and tumoricidal agent. In colorectal operations, this solution generally has been used for the purpose of minimizing postoperative septic complications and reducing cancer recurrence, although the optimal application, advantages, and undesirable side effects have been debated. With limited prospective, randomized, controlled trials and insufficient data available, this article examines the safe and effective clinical applications of this solution for colorectal operations.

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mentioning

confidence: 98%

Benefits of Povidone-Iodine Solution in Colorectal Operations: Science or Legend

Pattana-arun¹,

Wolff²

2008

Diseases of the Colon &Amp; Rectum

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“…Neutralization of iodophors occurs especially in the presence of whole blood, given hemoglobin’s ability to bind a large amount of iodine ( 55 ), but also occurs in the face of purulent material and fat homogenate ( 62 ). This finding may actually support the use of higher concentrations of PI when organic matter is present, as dilute solutions have a decreased reservoir of iodine, and therefore may be more readily neutralized ( 63 ). Iodophors display moderate persistence which is greatly extended up to 48 h when combined with alcohol ( 25 , 64 , 65 ).…”

Section: Iodine Compoundsmentioning

confidence: 89%

Small animal patient preoperative preparation: a review of common antiseptics, comparison studies, and resistance

Nye,

Thieman Mankin

2024

Front. Vet. Sci.

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This review aims to describe commonly used antiseptics in veterinary medicine including their mechanism of action, spectrum of activity, potential adverse effects, and application techniques. Additionally, it provides a review of the veterinary literature comparing antiseptics, a discussion of effectiveness and efficacy studies, and the potential for increased resistance to biocides and antimicrobials. This review concludes that appropriate selection and use is necessary to prevent the occurrence of surgical site infections, adverse effects, and potential for increasing resistance to antimicrobials. Continued research is needed to fill gaps in the current knowledge such as optimal preparation procedures for various surgical sites, standardization of efficacy and effectiveness testing, and the clinical impact of decreased susceptibility to chlorhexidine and other antiseptics.

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“…STS is well established as an appropriate neutralizing agent for PVI in experiments employing many different species of bacteria. [17][18][19][20] Experimental controls as described in the "experimental procedure" section were performed to ensure that the neutralizing agent itself did not inhibit bacterial growth.…”

Section: Neutralizationmentioning

confidence: 99%

10% Povidone-Iodine May Be a Practical Field Water Disinfectant

Heiner

Hile

Demons

et al. 2010

Wilderness & Environmental Medicine

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In vitro and in vivo bactericidal activities of 10%, 2.5%, and 1% povidone-iodine solution

Cited by 7 publications

References 0 publications

Benefits of Povidone-Iodine Solution in Colorectal Operations: Science or Legend

Benefits of Povidone-Iodine Solution in Colorectal Operations: Science or Legend

Small animal patient preoperative preparation: a review of common antiseptics, comparison studies, and resistance

10% Povidone-Iodine May Be a Practical Field Water Disinfectant

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