In Vitro and in Vivo Immunomodulatory Effects of RDP 1258, a Novel Synthetic Peptide

Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

“…RDP1258, when administered to rats, significantly increased splenic HO-1 activity but did not significantly alter the expression of HO-1 at the mRNA level (Magee et al, 1999). These peptides suppress immunorejection, partially through their binding to HO-1 (Magee et al, 1999). Since HO-1 expression was not up-regulated by this peptide and since the binding of these peptides to HO-1 is their main interaction with HO-1 protein (Magee et al, 1999), the reason why this class of peptides inhibits HO-1 activity in vitro, but stimulates HO-1 activity in vivo, is puzzling.…”

“…Its HO-1 inhibitory effect was shown in vitro in a dosedependent fashion (Cuturi et al, 1999). RDP1258, when administered to rats, significantly increased splenic HO-1 activity but did not significantly alter the expression of HO-1 at the mRNA level (Magee et al, 1999). These peptides suppress immunorejection, partially through their binding to HO-1 (Magee et al, 1999).…”

Heme Oxygenase-1 in Kidney Health and Disease

“…Magee et al studied the effects of a peptide inducer of HO-1, RDP1258, in rat renal allograft rejection (85). This peptide was modeled after a region in the HLA-B molecule that was shown to be protective in other models of transplant rejection.…”

Different Faces of the Heme-Heme Oxygenase System in Inflammation

“…Interactions with amyloid precursor proteins, which are implicated in the pathogenesis of Alzheimer disease, have been demonstrated to inhibit HO-1 activity, resulting in a compromised stress defense Takahashi and Snyder, 2000;Wagener et al, 2003b). On the other hand, Buelow and colleagues have demonstrated that the synthetic peptide RDP1258 can bind HO-1 and cause increased HO-1 expression and activity in vivo (Cuturi et al, 1999;Magee et al, 1999). This protein has further shown to be highly effective in ameliorating a range of inflammatory conditions (Cuturi et al, 1999;Oberyszyn et al, 2001).…”