In vitro and in vivo inhibition of LPS-induced tumor necrosis factor-α production by dimeric gallotannin analogues

Anti-inflammatory activity of Dasyphyllum brasiliensis (Asteraceae) on acute peritonitis induced by β-glucan from Histoplasma capsulatum

“…As far as we are concerned, the anti-inflammatory activity of hydrolysable tannins from Asteraceae has not been reported before. Although the phenolics described above are not commonly reported to occur in Asteraceae, their anti-inflammatory activities have been extensively described (Calixto et al, 2003(Calixto et al, , 2004Feldman et al, 2002).…”

“…The mechanisms underlying the anti-inflammatory effect of tannins include the scavenging of radicals (antioxidant effect) (Hagerman et al, 1999) and inhibition of inflammatory mediators, such as TNF-␣ (Feldman et al, 2002). This is an important observation, since gallic acid (hydrolysable tannin) is present in the active extract of Dasyphyllum brasiliensis and ellagic acid is the active constituent of Lafoensia pacari (Rogerio et al, 2006).…”

“…It cannot be ruled out the possibility that other phenolic compounds, which were found to be the major constituents of the active fractions of this species, may be responsible for the observed activity. It should be pointed out that plant species rich in phenolic compounds, like tannins and flavonoids, are currently being investigated regarding their anti-inflammatory activity (Calixto et al, 2003(Calixto et al, , 2004Feldman et al, 2002).…”

Cytoprotective effect of gallotannin in oxidatively stressed HaCaT keratinocytes: the role of poly(ADP‐ribose) metabolism

“…Moreover, PARP‐1 has also been implicated in retroviral infections as poly‐ADP ribosylation has been shown to facilitate viral integration (34). Similarly, GTs, inhibitors of PARG, have also been reported to inhibit production of tumor necrosis factor‐α and nitric oxide (22,35,36) as well as human immunodeficiency virus infection (37). Although these latter studies have not linked the effects of GT to PARG inhibition, it appears likely that GTs may have exerted these effects, at least in part, via PARG inhibition.…”