In vitro and in vivo biocompatibility of graded hydroxyapatite–zirconia composite bioceramic

Abstract

To obtain bioceramics with good osteoinductive ability and mechanical strength, graded hydroxyapatite-zirconia (HA-ZrO(2)) composite bioceramics were prepared in this work. The biocompatibility of the bioceramics was investigated in vitro based on acute toxicity and cytotoxicity tests and hemolysis assay. Results showed the studied graded HA-ZrO(2) had little toxicity to mouse and L929 mouse fibroblasts. Also, hemolysis assay indicated a good blood compatibility of the bioceramics. Based on the results of in vitro tests, animal experiments were performed on white New Zealand rabbits by implantation into hip muscles and femur. It was found that the graded HA-ZrO(2) composite bioceramics exhibited superior osteoinductive ability, which may be a promising bioceramics implant.

Antimicrobial activity of hemocompatible silver doped hydroxyapatite nanoparticles synthesized by modified sol–gel technique

“…Hemolytic assays are performed to examine interaction of nanoparticles with red blood cell membranes by measuring the released hemoglobin. HAp particles interact with numerous cellular systems in vivo and some of these interactions may lead to damaged cells and stimulate platelet activation, coagulation and thrombus formation (Wiessner et al 1988;Quan . 2008).…”

Calcium orthophosphate-based biocomposites and hybrid biomaterials

“…After implantation, the preferential dissolution of b-TCP phase would result in functionally gradient porosity for bone ingrowth [903]. HA/zirconia-graded biocomposites were fabricated to enhance the mechanical properties of HA while retaining its bone bonding property [791]. TiO 2 and HA were found to be a good combination for FGM providing both a gradient of bioactivity and a good mechanical strength [903].…”

Hard and soft tissue responses to three different implant materials in a dog model

“…Y-TZP also shows similar osseointegration as Ti implants 7,8) . Various modifications have been applied to experimental implants in order to improve the properties of zirconia implants for bone response, inflammatory response, biocompatibility and bacterial adherence [9][10][11][12] . Y-TZP has been compared with Ti in in vivo study and peri-implant bone response was not apparently different 13) .…”