In vitro and in vivo behavior of ketoprofen intercalated into layered double hydroxides

Abstract

Ketoprofen (Ket) was intercalated into layered double hydroxides (ZnAlLDH and MgAlLDH) using the ionic exchange method. The drug intercalation was confirmed by X-ray diffraction (XRD) and FTIR spectroscopy. Ket release from the inorganic matrix was studied at pH 7.4 in continuous regime with a flow rate of 0.5 and respectively 1.0 ml/min. The kinetical data were interpreted using the Ritger and Peppas model. The data prove that the release kinetics and mechanism depend on the eluent flow rate. Quantification of gastric tolerance shows that the ulcerogenic effect of the intercalated drug is lower than the one of the raw Ket. The antinociceptive effect of both formulations was studied by the hot-plate method performed on mice. The MgAlLDH_Ket formulation shows a tendency towards a stronger antinociceptive effect than its ZnAlLDH_Ket counterpart during the 210 min recorded period.

Comparative study of Mg/Al- and Zn/Al-layered double hydroxide-perindopril erbumine nanocomposites for inhibition of angiotensin-converting enzyme

“…The correlation between the M 2+ /Al 3+ ratio and d 003 for PMAE and PZAE is in good agreement with that reported previously in the literature. 23 Molecular structure and spatial orientation of intercalated perindopril Figure 2A shows the three-dimensional molecular size of perindopril obtained using Chemoff ice software (Cambridge, MA). The long and short axes (the x axis and y axis, respectively) and molecular thickness (z axis) of perindopril were calculated, giving values of 13 Å, 8.4 Å, and 12.6 Å, respectively.…”

Inorganic nanolayers: structure, preparation, and biomedical applications

“…Their study revealed that Ket LDHs reduced the ulcerogenic effect to a greater extent compared to free Ket. 192 Acetylsalicylic acid-dextran-coated LDH in vivo biocompatibility Dong et al designed drug-delivery systems based on dextrancoated LDHs for acetylsalicylic acid, and conducted a pharmacokinetic study with rabbits as the model animal. 160 They found the LDH-based delivery system increased the bioavailability and half-life and reduced the side effects of acetylsalicylic acid.…”

New hybrid materials based on layered double hydroxides and antioxidant compounds. Preparation, characterization and release kinetic studies

“…Secondly, the characteristic constant for VA is one order of magnitude higher than that of GA at both pH values, showing that VA is attached to the matrix with stronger interactions. Regarding the release process, our previous studies concerning ketoprofen intercalated into LDHs have demonstrated that it occurs primarily through ion exchange between the ions belonging to the buffer solution and the intercalated drug anions [57].…”