In Vitro and In Vivo Lung Deposition of Coated Magnetic Aerosol Particles

Xie, Yuanyuan; Longest, P. Worth; Xu, Yun; Wang, Jian Ping; Wiedmann, Timothy S.

doi:10.1002/jps.22168

Cited by 29 publications

(35 citation statements)

References 23 publications

(38 reference statements)

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“…In a following study, Xie et al [188] compared CFD, experimental, and in vivo models to characterize the deposition of a polydisperse aerosol with magnetite particles coated in oleic acid. They found no increased deposition in the mouse trachea, due to the distance between the trachea and the magnetic source.…”

Section: Cfd Models Of Aerosol Deposition In the Alveolar Airwaysmentioning

confidence: 99%

“…Magnetic particles that reach the alveolar region and are retained for two seconds require an induced magnetic velocity of 0.15 cm/s for full deposition. Magnetic velocities predicted by the CFD model showed that pulmonary targeting is possible, and Xie et al [188] state “This approach can form the basis for assessing the feasibility of magnetic targeted drug delivery in humans.” However, when designing future models, the need for a strong magnetic field to induce deposition at large distances must be considered. To address this issue, studies by Martin and Finlay [189] and Redman et al [190] have proposed using magnetic alignment of fibers to target drug deposition; however, a CFD optimization study of this approach has not previously been reported.…”

Section: Cfd Models Of Aerosol Deposition In the Alveolar Airwaysmentioning

confidence: 99%

“…As an extension of Xie et al [187, 188], the transport of magnetic aerosols was considered using a CFD model in an alveolar bifurcation starting at the eighteenth respiratory generation, as shown in Figure 5, for a tracheal inhalation flow rate of 30 L/min. The aerosol was composed of 1 µm droplets containing 10% by mass magnetite nanoparticles.…”

Section: Cfd Models Of Aerosol Deposition In the Alveolar Airwaysmentioning

confidence: 99%

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In silico models of aerosol delivery to the respiratory tract — Development and applications

Longest

Holbrook

2012

Advanced Drug Delivery Reviews

182

117

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This review discusses the application of computational models to simulate the transport and deposition of inhaled pharmaceutical aerosols from the site of particle or droplet formation to deposition within the respiratory tract. Traditional one-dimensional (1-D) whole-lung models are discussed briefly followed by a more in-depth review of three-dimensional (3-D) computational fluid dynamics (CFD) simulations. The review of CFD models is organized into sections covering transport and deposition within the inhaler device, the extrathoracic (oral and nasal) region, conducting airways, and alveolar space. For each section, a general review of significant contributions and advancements in the area of simulating pharmaceutical aerosols is provided followed by a more in-depth application or case study that highlights the challenges, utility, and benefits of in silico models. Specific applications presented include the optimization of an existing spray inhaler, development of charge-targeted delivery, specification of conditions for optimal nasal delivery, analysis of a new condensational delivery approach, and an evaluation of targeted delivery using magnetic aerosols. The review concludes with recommendations on the need for more refined model validations, use of a concurrent experimental and CFD approach for developing aerosol delivery systems, and development of a stochastic individual path (SIP) model of aerosol transport and deposition throughout the respiratory tract.

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Section: Cfd Models Of Aerosol Deposition In the Alveolar Airwaysmentioning

confidence: 99%

Section: Cfd Models Of Aerosol Deposition In the Alveolar Airwaysmentioning

confidence: 99%

Section: Cfd Models Of Aerosol Deposition In the Alveolar Airwaysmentioning

confidence: 99%

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In silico models of aerosol delivery to the respiratory tract — Development and applications

Longest

Holbrook

2012

Advanced Drug Delivery Reviews

182

117

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“…The iron content in this ferrofluid was determined to be $170 mg/ml based on the nanoparticle characterization protocol. 20 Experiments on tissue-equivalent gelatin phantom were conducted. We built a mold with a 22 mm-diameter hole surrounded by 5% cooled gelatin solution filling a thin-wall container (50 mm diameter, 20 mm height).…”

mentioning

confidence: 99%

Magnetoacoustic imaging of magnetic iron oxide nanoparticles embedded in biological tissues with microsecond magnetic stimulation

He²

2012

Applied Physics Letters

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We present an experimental study on magnetoacoustic imaging of superparamagnetic iron oxide (SPIO) nanoparticles embedded in biological tissues. In experiments, a large-current-carrying coil is used to deliver microsecond pulsed magnetic stimulation to samples. The ultrasound signals induced by magnetic forces on SPIO nanoparticles are measured by a rotating transducer. The distribution of nanoparticles is reconstructed by a back-projection imaging algorithm. The results demonstrated the feasibility to obtain cross-sectional image of magnetic nanoparticle targets with faithful dimensional and positional information, which suggests a promising tool for tomographic reconstruction of magnetic nanoparticle-labeled diseased tissues (e.g., cancerous tumor) in molecular or clinic imaging.

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“…This becomes more important when testing complex NMs since multiple synthesis steps increase the number of possible impurities. Only four animal studies were found that tested the inhalation of surface modified iron oxide nanoparticles [79][80][81][82]. The coatings included dextran, oleic acid, and fluorescent-labeled silica.…”

Section: Animal Inhalation Studies On Iron Oxide Nanoparticlesmentioning

confidence: 99%

Human inhalation exposure to iron oxide particles

2013

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Abstract:In the past decade, many studies have been conducted to determine the health effects induced by exposure to engineered nanomaterials (NMs). Specifically for exposure via inhalation, numerous in vitro and animal in vivo inhalation toxicity studies on several types of NMs have been published. However, these results are not easily extrapolated to judge the effects of inhaling NMs in humans, and few published studies on the human response to inhalation of NMs exist. Given the emergence of more industries utilizing iron oxide nanoparticles as well as more nanomedicine applications of superparamagnetic iron oxide nanoparticles (SPIONs), this review presents an overview of the inhalation studies that have been conducted in humans on iron oxides. Both occupational exposure studies on complex iron oxide dusts and fumes, as well as human clinical studies on aerosolized, micron-size iron oxide particles are discussed. Iron oxide particles have not been described to elicit acute inhalation response nor promote lung disease after chronic exposure. The few human clinical studies comparing inhalation of fine and ultrafine metal oxide particles report no acute changes in the health parameters measured. Taken together existing evidence suggests that controlled human exposure to iron oxide nanoparticles, such as SPIONs, could be conducted safely.

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In Vitro and In Vivo Lung Deposition of Coated Magnetic Aerosol Particles

Cited by 29 publications

References 23 publications

In silico models of aerosol delivery to the respiratory tract — Development and applications

In silico models of aerosol delivery to the respiratory tract — Development and applications

Magnetoacoustic imaging of magnetic iron oxide nanoparticles embedded in biological tissues with microsecond magnetic stimulation

Human inhalation exposure to iron oxide particles

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