In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa

Naseem, Shahid; Ismail, Hammad

doi:10.1186/s12906-022-03520-5

Cited by 13 publications

(14 citation statements)

References 86 publications

(103 reference statements)

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“…Serum Analysis. The serum obtained after centrifugation was analyzed according to the supplier's standard kits level using the Cobas® kits and standard protocols as reported previously [29,30]. The compounds analyzed included total serum protein, total serum bilirubin, blood urea nitrogen (BUN), serum creatinine, serum alanine transaminase (ALT), and serum aspartate transaminase (AST).…”

Section: Morris Water Mazementioning

confidence: 99%

Effects of Phoenix dactylifera against Streptozotocin‐Aluminium Chloride Induced Alzheimer’s Rats and Their In Silico Study

Ismail

Khalid

Ayub

et al. 2023

BioMed Research International

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Phoenix dactylifera is known for medicinal importance due to its antioxidant, antidiabetic, antidepressant, and anti-inflammatory properties. This study is aimed at evaluating the effect of P. dactylifera seeds to cure Alzheimer’s disease (AD). AD was induced in the rats with streptozotocin + aluminium chloride followed by treatment of methanolic extract of P. dactylifera seeds. The blood glucose levels were determined at regular intervals, which showed a prominent decrease in the extracts treated group. Behavior tests, including the Elevated Plus Maze (EPM) test and Morris Water Maze (MWM) test, were used to evaluate memory patterns in rats. The results indicated that extract-treated rats significantly improved memory behavior compared to the diseased group. After dissection, the serum electrolytes, antioxidant enzymes, and choline esterase enzymes were measured in different organs. The serum parameters creatinine, urea, and bilirubin increased after extract treatment. Similarly, the level of antioxidant enzymes like peroxidases (POD), glutathione (GSH), catalase (CAT), superoxide dismutase (SOD), and thiobarbituric acid reactive substance (TBARS) in the extract-treated group showed improved results that were close to the normal control group. The enzyme (lipase, insulin, amylase, and acetylcholine) levels were found enhanced in extract groups as compared to diseased rats. High-performance liquid chromatography (HPLC) was used to determine the level of dopamine and serotonin neurotransmitters, which were increased significantly for P. dactylifera seeds with values of 0.18 μg/mg tissue and 0.56 μg/mg tissue, respectively. Overall, results showed that P. dactylifera seeds proved to be quite efficient in improving the memory and behavior of treated rats. The antioxidants and enzymes were also increased; therefore, it may be a potential candidate for treating AD.

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Section: Morris Water Mazementioning

confidence: 99%

Effects of Phoenix dactylifera against Streptozotocin‐Aluminium Chloride Induced Alzheimer’s Rats and Their In Silico Study

Ismail

Khalid

Ayub

et al. 2023

BioMed Research International

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“…The study identifies bioactive constituents from methanol extracts such as phenols, flavonoids, oligosaccharides, coumarins and others that could be responsible for α-glucosidase inhibition/hypoglycemic activity. Recently, edible and hydroponically grown Lactuca sativa soil have been reported to substantially reduce blood glucose levels in diabetic rats besides in vitro α-glucosidase inhibition activity [ 63 ]. The crude extract and two isolated compounds Coniferol (1) and dillapiole (2) (from chloroform phyto-fractions) of Allium consanguineum were investigated for their hypoglycemic effects [ 64 ].…”

Section: Plant Extracts As α-Glucosidase Inhibitor Sourcesmentioning

confidence: 99%

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

Kashtoh

Baek

2022

Plants

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Diabetes is a common metabolic disorder marked by unusually high plasma glucose levels, which can lead to serious consequences such as retinopathy, diabetic neuropathy and cardiovascular disease. One of the most efficient ways to reduce postprandial hyperglycemia (PPHG) in diabetes mellitus, especially insulin-independent diabetes mellitus, is to lower the amount of glucose that is absorbed by inhibiting carbohydrate hydrolyzing enzymes in the digestive system, such as α-glucosidase and α-amylase. α-Glucosidase is a crucial enzyme that catalyzes the final stage of carbohydrate digestion. As a result, α-glucosidase inhibitors can slow D-glucose release from complex carbohydrates and delay glucose absorption, resulting in lower postprandial plasma glucose levels and control of PPHG. Many attempts have been made in recent years to uncover efficient α-glucosidase inhibitors from natural sources to build a physiologic functional diet or lead compound for diabetes treatment. Many phytoconstituent α-glucosidase inhibitors have been identified from plants, including alkaloids, flavonoids, anthocyanins, terpenoids, phenolic compounds, glycosides and others. The current review focuses on the most recent updates on different traditional/medicinal plant extracts and isolated compounds’ biological activity that can help in the development of potent therapeutic medications with greater efficacy and safety for the treatment of type 2 diabetes or to avoid PPHG. For this purpose, we provide a summary of the latest scientific literature findings on plant extracts as well as plant-derived bioactive compounds as potential α-glucosidase inhibitors with hypoglycemic effects. Moreover, the review elucidates structural insights of the key drug target, α-glucosidase enzymes, and its interaction with different inhibitors.

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“…The composition of lettuce shows a very high water content (94–95%), which is what makes this vegetable a low-calorie food. In addition, lettuce contains minerals, vitamins, glycosylated flavonoids, phenolic acids, tocopherols, carotenoids, polyphenols, and sesquiterpene lactones [ 181 , 182 , 183 , 184 ]. The intake of lettuce is the basis of various healthy effects.…”

Section: Nitrates–nitrites–nitric Oxide In Fruits and Vegetablesmentioning

confidence: 99%

The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management

Maiuolo

Oppedisano²,

Carresi³

et al. 2022

IJMS

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Reduced bioavailability of the nitric oxide (NO) signaling molecule has been associated with the onset of cardiovascular disease. One of the better-known and effective therapies for cardiovascular disorders is the use of organic nitrates, such as glyceryl trinitrate (GTN), which increases the concentration of NO. Unfortunately, chronic use of this therapy can induce a phenomenon known as “nitrate tolerance”, which is defined as the loss of hemodynamic effects and a reduction in therapeutic effects. As such, a higher dosage of GTN is required in order to achieve the same vasodilatory and antiplatelet effects. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is a cardioprotective enzyme that catalyzes the bio-activation of GTN to NO. Nitrate tolerance is accompanied by an increase in oxidative stress, endothelial dysfunction, and sympathetic activation, as well as a loss of the catalytic activity of ALDH2 itself. On the basis of current knowledge, nitrate intake in the diet would guarantee a concentration of NO such as to avoid (or at least reduce) treatment with GTN and the consequent onset of nitrate tolerance in the course of cardiovascular diseases, so as not to make necessary the increase in GTN concentrations and the possible inhibition/alteration of ALDH2, which aggravates the problem of a positive feedback mechanism. Therefore, the purpose of this review is to summarize data relating to the introduction into the diet of some natural products that could assist pharmacological therapy in order to provide the NO necessary to reduce the intake of GTN and the phenomenon of nitrate tolerance and to ensure the correct catalytic activity of ALDH2.

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In vitro and in vivo evaluations of antioxidative, anti-Alzheimer, antidiabetic and anticancer potentials of hydroponically and soil grown Lactuca sativa

Cited by 13 publications

References 86 publications

Effects of Phoenix dactylifera against Streptozotocin‐Aluminium Chloride Induced Alzheimer’s Rats and Their In Silico Study

Effects of Phoenix dactylifera against Streptozotocin‐Aluminium Chloride Induced Alzheimer’s Rats and Their In Silico Study

Recent Updates on Phytoconstituent Alpha-Glucosidase Inhibitors: An Approach towards the Treatment of Type Two Diabetes

The Generation of Nitric Oxide from Aldehyde Dehydrogenase-2: The Role of Dietary Nitrates and Their Implication in Cardiovascular Disease Management

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