In Vitro and In Vivo Comparison Study of Electrospun PLA and PLA/PVA/SA Fiber Membranes for Wound Healing

Bi, Hongyan; Feng, Tianyi; Li, Binbin; Han, Yingchao

doi:10.3390/polym12040839

Cited by 86 publications

(74 citation statements)

References 38 publications

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“…Any breach in the skin by wound causes invasion of microorganisms into the sensitive underneath tissues that lead to wound infection. The advanced research on wound dressing development suggests that the ideal wound dressing should provide a wet environment to the wound, absorb exudates from the wound, should be highly biocompatible, having good antimicrobial activity for quick tissue regeneration and mechanical features to remain intact [ 3 , 4 , 5 , 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

Starch-Capped Silver Nanoparticles Impregnated into Propylamine-Substituted PVA Films with Improved Antibacterial and Mechanical Properties for Wound-Bandage Applications

et al. 2020

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This research endeavor aims to develop polyvinyl alcohol (PVA) based films capable of blends with silver nanoparticles (Ag–NPs) for improved antibacterial properties and good mechanical strength to widen its scope in the field of wound dressing and bandages. This study reports synthesis of propylamine-substituted PVA (PA–PVA), Ag–NPs via chemical and green methods (starch capping) and their blended films in various proportions. Employment of starch-capped Ag–NPs as nanofillers into PVA films has substantially improved the above-mentioned properties in the ensuing nanocomposites. Synthesis of PA–PVA, starch-capped Ag–NPs and blended films were well corroborated with UV/Vis spectroscopy, FTIR, NMR, XRD and SEM analysis. Synthesized Ag–NPs were of particle shape and have an average size 20 nm and 40 nm via green and chemical synthesis, respectively. The successful blending of Ag–NPs was yielded up to five weight per weight into PA–PVA film as beyond this self-agglomeration of Ag–NPs was observed. Antibacterial assay has shown good antimicrobial activities by five weight per weight Ag–NPs(G)-encapsulated into PA–PVA blended film, i.e., 13 mm zone inhibition against Escherichia coli and 11 mm zone inhibition against Staphylococcus aureus. Physical strength was measured in the terms of young’s modulus via tensile stress–strain curves of blended films. The five weight per weight Ag–NPs(G)/PA–PVA blend film showed maximum tensile strength 168.2 MPa while three weight per weight Ag–NPs(G)/PVA blend film showed highest values for ultimate strain 297.0%. Ag–NPs embedment into PA–PVA was resulted in strong and ductile film blend than pristine PA–PVA film due to an increase in hydrogen bonding. These good results of five weight per weight Ag–NPs(G)/PA–PVA product make it a potent candidate for wound dressing application in physically active body areas.

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Section: Introductionmentioning

confidence: 99%

Starch-Capped Silver Nanoparticles Impregnated into Propylamine-Substituted PVA Films with Improved Antibacterial and Mechanical Properties for Wound-Bandage Applications

et al. 2020

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“…A schematic of the homemade triaxial electrospinning system is given in Figure 1 . As all other types of electrohydrodynamic atomization (EHDA) processes such as coaxial electrospinning and electrospraying, triaxial electrospinning has the similar essential four parts, i.e., fluid-driven pump, high-voltage generator, collector, and spinneret [ 51 , 52 ]. What makes differences are the spinneret and the corresponding numbers of syringe pumps.…”

Section: Resultsmentioning

confidence: 99%

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

et al. 2020

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In this study, a new modified triaxial electrospinning is implemented to generate an Eudragit S100 (ES100)-based core–shell structural nanofiber (CSF), which is loaded with aspirin. The CSFs have a straight line morphology with a smooth surface, an estimated average diameter of 740 ± 110 nm, and a clear core–shell structure with a shell thickness of 65 nm, as disclosed by the scanning electron microscopy and transmission electron microscopy results. Compared to the monolithic composite nanofibers (MCFs) produced using traditional blended single-fluid electrospinning, aspirin presented in both of them amorously owing to their good compatibility. The CSFs showed considerable advantages over the MCFs in providing the desired drug-controlled-release profiles, although both of them released the drug in an erosion mechanism. The former furnished a longer time period of time-delayed-release and a smaller portion released during the first two-hour acid condition for protecting the stomach membranes, and also showed a longer time period of aspirin-extended-release for avoiding possible drug overdose. The present protocols provide a polymer-based process-nanostructure-performance relationship to optimize the reasonable delivery of aspirin.

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“…PLA is a biocompatible, biodegradable, and bioabsorbable aliphatic thermoplastic polyester with valuable thermo-mechanical properties. These features, in addition to its non-toxicity to the human body, make it a suitable candidate for use in bioengineering [6,26,31,162]. In some applications, such as medical implants, PLA stereocomplex has attracted growing attention.…”

Section: Application Of Pla-based Electrospun Fibers In Wound Healingmentioning

confidence: 99%

“…In the case of non-compressible type of wounds, elasticity is another important requirement for a dressing to avoid wound compression. In addition, the wound dressing material should be soft, biocompatible, non-toxic, and non-allergenic [19,[26][27][28]. The effective healing process will improve by applying multifunctional wound dressings.…”

Section: Introductionmentioning

confidence: 99%

“…Owing to flexibility in choosing the raw materials and the possibility to tune the ultimate properties, the electrospinning technique has been extensively employed for biomedical materials like tissue engineering scaffolds, wound dressings, and drug delivery systems [7,8]. Electrospun structures composed of fibers with nano-scale diameter are proposed as ideal wound dressings and tissue substitutes due to their similarity to the extracellular matrix (ECM) fibrillar part [11,26,29,30]. Owing to the large specific surface area and high porosity with small pore size, these materials present efficient performance for improving the healing process.…”

Section: Introductionmentioning

confidence: 99%

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Bio-Based Electrospun Fibers for Wound Healing

Azimi

Maleki

Zavagna

et al. 2020

JFB

151

106

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Being designated to protect other tissues, skin is the first and largest human body organ to be injured and for this reason, it is accredited with a high capacity for self-repairing. However, in the case of profound lesions or large surface loss, the natural wound healing process may be ineffective or insufficient, leading to detrimental and painful conditions that require repair adjuvants and tissue substitutes. In addition to the conventional wound care options, biodegradable polymers, both synthetic and biologic origin, are gaining increased importance for their high biocompatibility, biodegradation, and bioactive properties, such as antimicrobial, immunomodulatory, cell proliferative, and angiogenic. To create a microenvironment suitable for the healing process, a key property is the ability of a polymer to be spun into submicrometric fibers (e.g., via electrospinning), since they mimic the fibrous extracellular matrix and can support neo- tissue growth. A number of biodegradable polymers used in the biomedical sector comply with the definition of bio-based polymers (known also as biopolymers), which are recently being used in other industrial sectors for reducing the material and energy impact on the environment, as they are derived from renewable biological resources. In this review, after a description of the fundamental concepts of wound healing, with emphasis on advanced wound dressings, the recent developments of bio-based natural and synthetic electrospun structures for efficient wound healing applications are highlighted and discussed. This review aims to improve awareness on the use of bio-based polymers in medical devices.

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In Vitro and In Vivo Comparison Study of Electrospun PLA and PLA/PVA/SA Fiber Membranes for Wound Healing

Cited by 86 publications

References 38 publications

Starch-Capped Silver Nanoparticles Impregnated into Propylamine-Substituted PVA Films with Improved Antibacterial and Mechanical Properties for Wound-Bandage Applications

Starch-Capped Silver Nanoparticles Impregnated into Propylamine-Substituted PVA Films with Improved Antibacterial and Mechanical Properties for Wound-Bandage Applications

Core–Shell Eudragit S100 Nanofibers Prepared via Triaxial Electrospinning to Provide a Colon-Targeted Extended Drug Release

Bio-Based Electrospun Fibers for Wound Healing

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